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  • 1
    Electronic Resource
    Electronic Resource
    Influence of tumour depth, blood absorption and autofluorescence on measurements of exogenous fluorophores in tissue (1998)
    Springer
    Lasers in medical science 13 (1998), S. 22-31 
    Details
    ISSN: 1435-604X
    Keywords: Carothenoporphyrin ; Fluorescence ratio ; Fluorescence spectroscopy ; Tissue optics ; Tumour detection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract We investigated the influence of tumour depth and differences in blood concentration and autofluorescence between tumour and normal tissue on the fluorescence of a tumour-localising agent. Carotenoporphyrin, CP(Me)3, was injected into rats and nude mice with intradermal tumours. On the tumours an incision was made, uncovering 2 mm2 of the tumour, and fluorescence measurements, including excitation-emission maps and fluorescence ratios, were made on skin, covered and uncovered tumour. The measured fluorescence ratio in the uncovered tumour showed a three- to tenfold increase compared to the covered tumour. We used a one-dimensional layered tissue model to analyse the data. In conclusion, even with a high tumour-selectivity deeper lying tumours cannot always be detected, particularly if the tumour has a high blood concentration or low autofluorescence intensity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00592957
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  • 2
    Electronic Resource
    Electronic Resource
    The spectral dependence of the optical properties of human brain (1989)
    Springer
    Lasers in medical science 4 (1989), S. 221-227 
    Details
    ISSN: 1435-604X
    Keywords: Optical properties ; Photodynamic therapy ; Glioma ; Brain tumour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract The in vitro optical properties of slices of human brain tissue were measured. The experiments were performed with an integrating sphere and covered the wavelength range from 400 to 1100 nm. Both normal brain tissue (white and grey matter) and tumour tissue (a malignant glioma and a melanotic melanoma) were investigated. From the experimental data the Kubelka-Munk absorption and scattering coefficients were determined. From these data we calculated the transport absorption and scattering coefficients by using the diffusion approximation. Blood and water appeared to be the dominant chromophores. In the wavelength range mentioned, the absorption coefficients varied over more than two orders of magnitude. The scattering coefficients increased slowly towards the shorter wavelengths.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02032451
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  • 3
    Electronic Resource
    Electronic Resource
    Laserlithotripsy of salivary stones: A comparison between the pulsed dye laser and the Ho-YSGG laser (1990)
    Springer
    Lasers in medical science 5 (1990), S. 357-363 
    Details
    ISSN: 1435-604X
    Keywords: Laser lithotripsy ; Salivary calculi ; Pulsed 504 dye laser ; Ho-YSGG laser ; Ablation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract The feasibility of laser lithotripsy of salivary stones was investigated. Two types of laser systems were evaluated: a 504 nm flashlamp pumped dye laser and a Ho-YSGG laser. With the dye laser, plasma flashes and acoustic phenomena could be observed. The number of laser shots per unit mass necessary to fragment the stone decreased in proportion to the energy per laser pulse to the power −2.7. With the Ho-YSGG laser, a more ablative kind of stone decomposition was observed. Here the number of shots per unit mass necessary for fragmentation was inversely proportional to the energy per laser pulse. For both lasers the total time necessary to fragment the stones is much too long to compete with conventional stone removal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02032592
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