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  • 1
    Electronic Resource
    Electronic Resource
    Dielectric measurements with time-domain reflectometry when large conductivities are involved (1971)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 75 (1971), S. 1323-1324 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100679a028
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  • 2
    Electronic Resource
    Electronic Resource
    Thermolysis of port-wine-stain blood vessels: Diameter of a damaged blood vessel depends on the laser pulse length (1996)
    Springer
    Lasers in medical science 11 (1996), S. 177-180 
    Details
    ISSN: 1435-604X
    Keywords: Port-wine stain ; Photothermolysis ; Laser treatment ; Vascular injury ; Laser pulse length ; Blood vessel diameter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract A thermal model of blood vessel damage during the laser treatment of port-wine stains (PWS) is presented. The model depends on the heat generation in a blood vessel caused by the absorption of laser light and the thermodiffusion of that heat through the dermis. The criterion of vessel injury adopted was an average vessel temperature of 70 °C. Results show that for a chosen combination of pulse length and radiant exposure, only blood vessels within a certain diameter range will be injured. This is in agreement with the pulse length selective photothermolysis criteria suggested previously by Anderson and Parrish (1). The Anderson and Parrish model relies on the cooling behaviour of instantaneously heated vessels, whereas the present study utilizes the heating of the vessel by a Gaussian temporal laser pulse profile. Predictions based on one blood vessel were verified in a skin model with multiple blood vessels by simulating vessel coagulation with a single laser treatment. The diameter of the blood vessels that are damaged during laser treatment of PWS depends on the laser pulse length.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02156760
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  • 3
    Electronic Resource
    Electronic Resource
    The spectral dependence of the optical properties of human brain (1989)
    Springer
    Lasers in medical science 4 (1989), S. 221-227 
    Details
    ISSN: 1435-604X
    Keywords: Optical properties ; Photodynamic therapy ; Glioma ; Brain tumour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract The in vitro optical properties of slices of human brain tissue were measured. The experiments were performed with an integrating sphere and covered the wavelength range from 400 to 1100 nm. Both normal brain tissue (white and grey matter) and tumour tissue (a malignant glioma and a melanotic melanoma) were investigated. From the experimental data the Kubelka-Munk absorption and scattering coefficients were determined. From these data we calculated the transport absorption and scattering coefficients by using the diffusion approximation. Blood and water appeared to be the dominant chromophores. In the wavelength range mentioned, the absorption coefficients varied over more than two orders of magnitude. The scattering coefficients increased slowly towards the shorter wavelengths.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02032451
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  • 4
    Electronic Resource
    Electronic Resource
    Editorial (1995)
    Springer
    Lasers in medical science 10 (1995), S. 1-1 
    Details
    ISSN: 1435-604X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02133155
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  • 5
    Electronic Resource
    Electronic Resource
    Palliative treatment of AIDS-related Kaposi's sarcoma in the upper aerodigestive tract with the carbon dioxide laser (1995)
    Springer
    Lasers in medical science 10 (1995), S. 127-130 
    Details
    ISSN: 1435-604X
    Keywords: Kaposi's Sarcoma ; AIDS ; Laser surgery ; Carbon dioxide laser ; Otolaryngological manifestations ; Upper aerodigestive tract
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract AIDS-related Kaposi's Sarcoma (KS) in the upper aerodigestive tract, although mainly asymptomatic, sometimes causes pain, bleeding or interferes with food intake and gas exchange. In trying to overcome some of the disadvantages of currently applied treatment modalities (i.e. surgery, radiotherapy and chemotherapy), the carbon dioxide laser was used to remove this vascular tumour in selected cases. Of the 16 patients treated, 12 did not develop recurrent disease at the treated site during follow-up (1 month to 1 year). In the four remaining patients, the intervention lead to a substantial reduction in symptoms. Post-operative morbidity was minimal except in two patients, one of whom developed an oro-antral fistula after extraction of teeth during the operation, the other developing osteomyelitis of the hard palate at the treated site. Both patients had been irradiated previously. Thus the carbon dioxide laser proved to be an effective tool for palliative treatment in selected cases of KS in the upper aerodigestive tract.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02150850
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  • 6
    Electronic Resource
    Electronic Resource
    Infra-red tomography of port-wine-stain blood vessels in human skin (1996)
    Springer
    Lasers in medical science 11 (1996), S. 199-204 
    Details
    ISSN: 1435-604X
    Keywords: Port-wine stain ; Infra-red tomography ; Laser treatment ; Blood vessel ; Photothermolysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract Specifying the distribution of laser energy within a tissue is the first step towards understanding and capitalizing on a variety of laser-tissue interactions. Whether photothermal, photochemical or photomechanical in nature, laser-tissue interactions begin with the absorption of photon energy. The spatial distribution of photon absorption specifies the required laser exposure to be delivered and the extent of subsequent therapeutic action. Using infra-red tomography (IRT), the broad, long-term objective of this research is the development of a tomographic reconstruction algorithm as a means to determine: (1) the depths and physical dimensions of discrete subsurface port-wine-stain (PWS) blood vessels in human skin; and (2) the initial space-dependent temperature increase in PWS blood vessels immediately following pulsed laser exposure. In this report, preliminary studies are described which demonstrate the potential application of IRT in the clinical management of PWS patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02156765
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  • 7
    Electronic Resource
    Electronic Resource
    Excimer laser coronary angioplasty: Initial experience in Amsterdam (1991)
    Springer
    Lasers in medical science 6 (1991), S. 281-288 
    Details
    ISSN: 1435-604X
    Keywords: Coronary angioplasty ; Excimer laser ; Light fluence rate distribution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract This paper reports on the initial clinical experience with 308 nm XeCl-excimer laser coronary angioplasty (ELCA) in the Academic Medical Center in Amsterdam and on calculations of light fluence rate distributions resulting from laser beams incident on tissue. Monte Carlo numerical computations were used to compute the light fluence rate distributions of a finite 308 nm excimer laser beam with various diameters incident on a liquid-tissue interface. It was found that light scattering is an important component in the resulting light distribution in aortic tissue. The calculations predict that there will be hardly any broadening of the beam outside the laser beam area. Therefore, the distributions from different fibres in multifibre catheters will not overlap unless the fibres are closely packed together. As a consequence of scattering the fluence rate at the surface of the tissue was larger than the incident power density and showed a considerable decrease from the centre to the edge of the beam. However, the physics of tissue ablation by fibres in contact with tissue are different and at present not well understood. The clinical results of the first 18 patients treated with the Dymer 200+ excimer laser (Advanced Interventional Systems, Irvine, CA, USA) are given. Six patients had abrupt closure solved by balloon angioplasty, but complicated by a small myocardial infarction. One patient had emergency by-pass surgery for abrupt closure after laser followed by balloon angioplasty (probably a dissection and thrombus). In one patient we perforated in a bend of a RCA with a 2.0 catheter following a second pass. We had two in hospital deaths (4 and 14 days after treatment). At 6 months follow-up, eight patients had restenosis or occlusion at the lased segment. However, the results of the first 1000 patients enrolled in the American ELCA-Registry are more promising. In the light of these results it can be concluded that a randomized trial balloon angioplasty versus excimer laser angioplasty appears to be indicated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02030881
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  • 8
    Electronic Resource
    Electronic Resource
    Has the argon laser ever been used optimally for the treatment of port wine stain birthmarks? (1991)
    Springer
    Lasers in medical science 6 (1991), S. 371-371 
    Details
    ISSN: 1435-604X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02042458
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  • 9
    Electronic Resource
    Electronic Resource
    Laserlithotripsy of salivary stones: A comparison between the pulsed dye laser and the Ho-YSGG laser (1990)
    Springer
    Lasers in medical science 5 (1990), S. 357-363 
    Details
    ISSN: 1435-604X
    Keywords: Laser lithotripsy ; Salivary calculi ; Pulsed 504 dye laser ; Ho-YSGG laser ; Ablation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract The feasibility of laser lithotripsy of salivary stones was investigated. Two types of laser systems were evaluated: a 504 nm flashlamp pumped dye laser and a Ho-YSGG laser. With the dye laser, plasma flashes and acoustic phenomena could be observed. The number of laser shots per unit mass necessary to fragment the stone decreased in proportion to the energy per laser pulse to the power −2.7. With the Ho-YSGG laser, a more ablative kind of stone decomposition was observed. Here the number of shots per unit mass necessary for fragmentation was inversely proportional to the energy per laser pulse. For both lasers the total time necessary to fragment the stones is much too long to compete with conventional stone removal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02032592
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  • 10
    Electronic Resource
    Electronic Resource
    Transmyocardial revascularization (1995)
    Springer
    Lasers in medical science 10 (1995), S. 83-91 
    Details
    ISSN: 1435-604X
    Keywords: Transmyocardial revascularization ; Lasers ; Coronary artery disease ; Ischaemia ; Tissue hibernation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract Transmyocardial revascularization (TMR) is a puncture technique proposed as a solution for patients with coronary artery disease who cannot be efficiently treated with the standard revascularization procedures such as bypass surgery or percutaneous transluminal coronary angioplasty (PTCA). The studies presented in this review have investigated the use of lasers to revascularize ischaemic myocardium. Needle puncture methods are also briefly described. The results from experimental studies are not conclusive but the encouraging clinical reports raise further questions about the mechanism of angina relief.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02150845
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