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  • Oxford University Press  (59)
  • American Association for the Advancement of Science (AAAS)
  • 1
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    Elucidation of binding specificity of Jacalin toward O-glycosylated peptides: quantitative analysis by frontal affinity chromatography (2005)
    Oxford University Press
    Details
    Publication Date: 2005-09-21
    Print ISSN: 0959-6658
    Electronic ISSN: 1460-2423
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 2
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    Incorporation of histone H3.1 suppresses the lineage potential of skeletal muscle (2015)
    Oxford University Press
    Details
    Publication Date: 2015-01-24
    Description: Lineage potential is triggered by lineage-specific transcription factors in association with changes in the chromatin structure. Histone H3.3 variant is thought to play an important role in the regulation of lineage-specific genes. To elucidate the function of H3.3 in myogenic differentiation, we forced the expression of GFP-H3.1 to alter the balance between H3.1 and H3.3 in mouse C2C12 cells that could be differentiated into myotubes. GFP-H3.1 replaced H3.3 in the regulatory regions of skeletal muscle (SKM) genes and induced a decrease of H3K4 trimethylation (H3K4me3) and increase of H3K27 trimethylation (H3K27me3). Similar results were obtained by H3.3 knockdown. In contrast, MyoD-dependent H3.3 incorporation into SKM genes in fibroblasts induced an increase of H3K4me3 and H3K27me3. In mouse embryos, a bivalent modification of H3K4me3 and H3K27me3 was formed on H3.3-incorporated SKM genes before embryonic skeletal muscle differentiation. These results suggest that lineage potential is established through a selective incorporation of specific H3 variants that governs the balance of histone modifications.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 3
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    Hippocampal dysfunction in the Euchromatin histone methyltransferase 1 heterozygous knockout mouse model for Kleefstra syndrome (2013)
    Oxford University Press
    Details
    Publication Date: 2013-02-02
    Description: Euchromatin histone methyltransferase 1 (EHMT1) is a highly conserved protein that catalyzes mono- and dimethylation of histone H3 lysine 9, thereby epigenetically regulating transcription. Kleefstra syndrome (KS), is caused by haploinsufficiency of the EHMT1 gene, and is an example of an emerging group of intellectual disability (ID) disorders caused by genes encoding epigenetic regulators of neuronal gene activity. Little is known about the mechanisms underlying this disorder, prompting us to study the Euchromatin histone methyltransferase 1 heterozygous knockout ( Ehmt1 +/– ) mice as a model for KS. In agreement with the cognitive disturbances observed in patients with KS, we detected deficits in fear extinction learning and both novel and spatial object recognition in Ehmt1 +/– mice. These learning and memory deficits were associated with a significant reduction in dendritic arborization and the number of mature spines in hippocampal CA1 pyramidal neurons of Ehmt1 +/– mice. In-depth analysis of the electrophysiological properties of CA3-CA1 synapses revealed no differences in basal synaptic transmission or theta-burst induced long-term potentiation (LTP). However, paired-pulse facilitation (PPF) was significantly increased in Ehmt1 +/– neurons, pointing to a potential deficiency in presynaptic neurotransmitter release. Accordingly, a reduction in the frequency of miniature excitatory post-synaptic currents (mEPSCs) was observed in Ehmt1 +/– neurons. These data demonstrate that Ehmt1 haploinsufficiency in mice leads to learning deficits and synaptic dysfunction, providing a possible mechanism for the ID phenotype in patients with KS.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 4
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    Hayabusa2 arrives at the carbonaceous asteroid 162173 Ryugu--A spinning top-shaped rubble pile (2019)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2019
    Description: 〈p〉The Hayabusa2 spacecraft arrived at the near-Earth carbonaceous asteroid 162173 Ryugu in 2018. We present Hayabusa2 observations of Ryugu’s shape, mass, and geomorphology. Ryugu has an oblate ‘spinning top’ shape with a prominent circular equatorial ridge. Its bulk density, 1.19 ± 0.02 g cm〈sup〉–3〈/sup〉, indicates a high porosity (〉50%) interior. Large surface boulders suggest a rubble-pile structure. Surface slope analysis shows Ryugu’s shape may have been produced if it once spun at twice the current rate. Coupled with the observed global material homogeneity, this suggests that Ryugu was reshaped by centrifugally induced deformation during a period of rapid rotation. From these remote-sensing investigations, we identify a suitable sample collection site on the equatorial ridge.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Altered nociceptive neuronal circuits after neonatal peripheral inflammation (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-08-01
    Description: Nociceptive neuronal circuits are formed during embryonic and postnatal times when painful stimuli are normally absent or limited. Today, medical procedures for neonates with health risks can involve tissue injury and pain for which the long-term effects are unknown. To investigate the impact of neonatal tissue injury and pain on development of nociceptive neuronal circuitry, we used an animal model of persistent hind paw peripheral inflammation. We found that, as adults, these animals exhibited spinal neuronal circuits with increased input and segmental changes in nociceptive primary afferent axons and altered responses to sensory stimulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ruda, M A -- Ling, Q D -- Hohmann, A G -- Peng, Y B -- Tachibana, T -- New York, N.Y. -- Science. 2000 Jul 28;289(5479):628-31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cellular Neuroscience Section, Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health (NIH), Bethesda, MD 20892, USA. maruda@dir.nidcr.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10915627" target="_blank"〉PubMed〈/a〉
    Keywords: Afferent Pathways ; Animals ; Animals, Newborn ; Axons/physiology ; Cell Count ; Freund's Adjuvant ; Ganglia, Spinal/cytology/physiology ; Hindlimb/innervation ; Inflammation/physiopathology ; Male ; Neurons, Afferent/cytology/*physiology ; *Pain ; Pain Measurement ; Pain Threshold ; Posterior Horn Cells/cytology/*physiology ; Rats ; Rats, Sprague-Dawley ; Sciatic Nerve/cytology/physiology ; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-02-09
    Description: Mouse CD4+CD8+ double-positive (DP) thymocytes differentiate into CD4+ helper-lineage cells upon expression of the transcription factor Th-POK but commit to the CD8+ cytotoxic lineage in its absence. We report the redirected differentiation of class I-restricted thymocytes into CD4+CD8- helper-like T cells upon loss of Runx transcription factor complexes. A Runx-binding sequence within the Th-POK locus acts as a transcriptional silencer that is essential for Th-POK repression and for development of CD8+ T cells. Thus, Th-POK expression and genetic programming for T helper cell development are actively inhibited by Runx-dependent silencer activity, allowing for cytotoxic T cell differentiation. Identification of the transcription factors network in CD4 and CD8 lineage choice provides insight into how distinct T cell subsets are developed for regulating the adaptive immune system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Setoguchi, Ruka -- Tachibana, Masashi -- Naoe, Yoshinori -- Muroi, Sawako -- Akiyama, Kaori -- Tezuka, Chieko -- Okuda, Tsukasa -- Taniuchi, Ichiro -- New York, N.Y. -- Science. 2008 Feb 8;319(5864):822-5. doi: 10.1126/science.1151844.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18258917" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Cell Lineage ; Chromatin Immunoprecipitation ; Core Binding Factor Alpha 2 Subunit/genetics/*physiology ; Core Binding Factor Alpha 3 Subunit/genetics/*physiology ; Core Binding Factor beta Subunit/metabolism ; Histocompatibility Antigens Class I/immunology ; Histocompatibility Antigens Class II/immunology ; Mice ; Mice, Transgenic ; Molecular Sequence Data ; Silencer Elements, Transcriptional ; T-Lymphocyte Subsets/cytology/*immunology/metabolism ; T-Lymphocytes, Cytotoxic/cytology/*immunology/metabolism ; T-Lymphocytes, Helper-Inducer/cytology/immunology/metabolism ; Transcription Factors/genetics/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-09-07
    Description: Developmental gene expression is defined through cross-talk between the function of transcription factors and epigenetic status, including histone modification. Although several transcription factors play crucial roles in mammalian sex determination, how epigenetic regulation contributes to this process remains unknown. We observed male-to-female sex reversal in mice lacking the H3K9 demethylase Jmjd1a and found that Jmjd1a regulates expression of the mammalian Y chromosome sex-determining gene Sry. Jmjd1a directly and positively controls Sry expression by regulating H3K9me2 marks. These studies reveal a pivotal role of histone demethylation in mammalian sex determination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kuroki, Shunsuke -- Matoba, Shogo -- Akiyoshi, Mika -- Matsumura, Yasuko -- Miyachi, Hitoshi -- Mise, Nathan -- Abe, Kuniya -- Ogura, Atsuo -- Wilhelm, Dagmar -- Koopman, Peter -- Nozaki, Masami -- Kanai, Yoshiakira -- Shinkai, Yoichi -- Tachibana, Makoto -- New York, N.Y. -- Science. 2013 Sep 6;341(6150):1106-9. doi: 10.1126/science.1239864.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, 53 Shogoin, Kawara-cho, Sakyo-ku, Kyoto, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24009392" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Epididymis/abnormalities ; *Epigenesis, Genetic ; Female ; *Gene Expression Regulation, Developmental ; Histones/*metabolism ; Jumonji Domain-Containing Histone Demethylases/genetics/*metabolism ; Male ; Methylation ; Mice ; Mice, Mutant Strains ; Mice, Transgenic ; Ovary/abnormalities/enzymology ; *Protein Processing, Post-Translational ; Sex Determination Processes/*genetics ; Testis/abnormalities/enzymology ; Uterus/abnormalities
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Epidermal cell differentiation in Arabidopsis determined by a Myb homolog, CPC (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-08-22
    Description: The roots of plants normally carry small hairs arranged in a regular pattern. Transfer DNA-tagged lines of Arabidopsis thaliana included a mutant with few, randomly distributed root hairs. The mutated gene CAPRICE (CPC) encoded a protein with a Myb-like DNA binding domain typical of transcription factors involved in animal and plant development. Analysis in combination with other root hair mutations showed that CPC may work together with the TTG gene and upstream of the GL2 gene. Transgenic plants overexpressing CPC had more root hairs and fewer trichomes than normal. Thus, the CPC gene determines the fate of epidermal cell differentiation in Arabidopsis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wada, T -- Tachibana, T -- Shimura, Y -- Okada, K -- New York, N.Y. -- Science. 1997 Aug 22;277(5329):1113-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division I of Gene Expression and Regulation, National Institute for Basic Biology, Okazaki, 444, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9262483" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Arabidopsis/*cytology/*genetics ; *Arabidopsis Proteins ; Cell Differentiation ; Crosses, Genetic ; DNA-Binding Proteins/chemistry/*genetics/physiology ; Genes, Plant ; Homeodomain Proteins/genetics ; Molecular Sequence Data ; Mutation ; Oncogenes ; Phenotype ; Plant Proteins/genetics ; Plant Roots/*cytology/genetics ; Plants, Genetically Modified ; Proto-Oncogene Proteins/chemistry/genetics ; Proto-Oncogene Proteins c-myb ; Trans-Activators/chemistry/genetics ; Transcription Factors/chemistry/*genetics/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Hayabusa2 arrives at the carbonaceous asteroid 162173 Ryugu--A spinning top-shaped rubble pile (2019)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2019
    Description: 〈p〉The Hayabusa2 spacecraft arrived at the near-Earth carbonaceous asteroid 162173 Ryugu in 2018. We present Hayabusa2 observations of Ryugu’s shape, mass, and geomorphology. Ryugu has an oblate "spinning top" shape, with a prominent circular equatorial ridge. Its bulk density, 1.19 ± 0.02 grams per cubic centimeter, indicates a high-porosity (〉50%) interior. Large surface boulders suggest a rubble-pile structure. Surface slope analysis shows Ryugu’s shape may have been produced from having once spun at twice the current rate. Coupled with the observed global material homogeneity, this suggests that Ryugu was reshaped by centrifugally induced deformation during a period of rapid rotation. From these remote-sensing investigations, we identified a suitable sample collection site on the equatorial ridge.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Elasto-plastic modelling of shear failure of the plate boundary decollement zone (2018)
    Oxford University Press
    Details
    Publication Date: 2018
    Description: 〈span〉〈div〉Summary〈/div〉The recently evolving crustal deformation monitoring systems detect slow slip events, which are failures that are slower-paced than ordinary earthquakes, in the decollement zone of the shallow part of the plate subduction boundary zone. When the 2011 earthquake off the Pacific coast of Tohoku occurred, the decollement zone became the source of a massive tsunami. Deep-sea scientific drilling of the decollement zone has shown that the surrounding shear zone area is composed of a mixture of smectite and illite. These clay minerals differ in their frictional characteristics. This study proposes a mathematical model using a continuity equation to express the interactions between the solid and liquid phases and an elasto-plastic constitutive relation for the soil skeleton, considering the alteration of smectite to illite. In doing so, the decollement zone is viewed as a problem involving soil/water coupling in a mixture, where the soil skeleton is the solid and the pore water is the liquid. The dehydration of interlayer water in smectite, changes in frictional characteristics resulting from illitization, and changes in dilatancy characteristics are considered in this model. Shear simulations were also conducted, factoring in alteration. The simulation results revealed that the shear strength increased with alteration, and accordingly shear stress increased when the shear deformation is further applied. Since the shear strength increased with alteration, shear deformation was less likely to occur in the decollement zone, and it was considered that the sticking between the plate could be simulated.〈/span〉
    Print ISSN: 2051-1965
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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