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  • Books  (51)
  • MDPI - Multidisciplinary Digital Publishing Institute  (51)
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  • Books  (51)
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  • 1
    Publication Date: 2023-12-20
    Description: Climate change will bring about significant changes to the capacity of, and the demand on, water resources. The resulting changes include increasing climate variability that is expected to affect hydrologic conditions. The effects of climate variability on various meteorological variables have been extensively observed in many regions around the world. Atmospheric circulation, topography, land use and other regional features modify global changes to produce unique patterns of change at the regional scale. As the future changes to these water resources cannot be measured in the present, hydrological models are critical in the planning required to adapt our water resource management strategies to future climate conditions. Such models include catchment runoff models, reservoir management models, flood prediction models, groundwater recharge and flow models, and crop water balance models. In water-scarce regions such as Australia, urban water systems are particularly vulnerable to rapid population growth and climate change. In the presence of climate change induced uncertainty, urban water systems need to be more resilient and multi-sourced. Decreasing volumetric rainfall trends have an effect on reservoir yield and operation practices. Severe intensity rainfall events can cause failure of drainage system capacity and subsequent urban flood inundation problems. Policy makers, end users and leading researchers need to work together to develop a consistent approach to interpreting the effects of climate variability and change on water resources. This Special Edition includes papers by international experts who have investigated climate change impacts on a variety of systems including irrigation and water markets, land use changes and vegetation growth, lake water levels and quality and sea level rises. These investigations have been conducted in many regions of the world including the USA, China, East Africa, Australia, Taiwan and the Sultanate of Oman.
    Keywords: GE1-350 ; G1-922 ; meteorological variables ; water resources management ; uncertainty ; hydrological models ; climate models ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCN Environmental economics
    Language: English
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  • 2
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: The terrorist attacks on the World Trade Center towers on September 11, 2001, also referred as 9/11, was an iconic event in US history that altered the global and political response to terrorism. The attacks, which involved two planes hitting the twin towers in Lower Manhattan, New York City, resulted in the collapse of the buildings and over 2800 deaths of occupants of the buildings, fire, police and other responders and persons on the street in the vicinity of the collapsing buildings. The destroyed towers and the surrounding buildings have since been replaced but the health effects that resulted from the release of tons of dust, gases and debris as well as the life threat trauma are ongoing, and represent a major health burden among persons directly exposed. Hundreds of scientific publications have documented the physical and mental health effects attributed to the disaster. The current state-of-the-art in understanding the ongoing interactions of physical and mental health, especially PTSD, and the unique mechanisms by which pollutants from the building collapse, have resulted in long term pulmonary dysfunction, course of previously reported conditions, potential emerging conditions (e.g., heart disease and autoimmune diseases), as well as quality of life, functioning and unmet health care needs would be in the purview of this Special Issue on the 9/11 Disaster.
    Keywords: B1-5802 ; n/a ; asthma outcomes ; health insurance ; mental health ; handgrip strength ; WTC ; cognitive reserve ; disaster epidemiology ; surveillance bias ; cardiac sarcoidosis ; lung function ; lung injury ; treatment utilization ; injury ; Cox regression ; lower Manhattan residents ; chronic sinusitis ; social support ; indoor allergens sensitization ; respiratory function ; FDNY ; asthma control ; sarcoidosis ; asthma ; 9/11 impact ; physical health ; rescue/recovery workers ; chronic disease ; evidence-based treatment ; irritant(s) ; fibrosis ; unmet mental health care needs ; airway hyperreactivity ; asthma quality of life ; Short Form-12 (SF-12) ; WTC-related asthma ; longitudinal analysis ; forced oscillation ; thyroid cancer ; psychotherapy ; cognitive decline ; 9/11 disaster ; severe lung disease ; prevalence ; inflammation ; pulmonary function tests ; World Trade Center disaster ; disaster mental health ; epidemiological studies ; obstructive sleep apnea ; counseling ; sleepiness ; PTSD ; hazard function ; cleaning practices ; air pollution ; aging ; stressful life events ; airway physiology ; screening ; PTSD cluster ; latent class analysis ; retirement ; environmental health ; World Trade Center ; quality improvement ; pulmonary fibrosis ; WTC attack ; dust ; PCL score ; WTC responders ; mini asthma quality of life questionnaire ; biomarkers ; HQoL ; health-related quality of life ; Scadding stage ; 9/11 ; firefighters ; allergen exposure ; metabolic syndrome ; neuropathic symptoms ; small airway disease ; Asian Americans ; asthma morbidity ; PTSD symptom change ; WTC survivors ; trigger(s) ; World Trade Center exposure ; occupational exposure ; peripheral neuropathy ; disaster ; respiratory symptoms ; mental health treatment ; genetics ; mental health service utilization ; comorbid insomnia ; sleep-related quality of life ; World Trade Center attack ; immunoglobulin E ; mental health service use ; income loss ; paresthesia ; World Trade Center (WTC) ; fibrotic sarcoid ; depression ; post-disaster ; mental health conditions ; extrathoracic sarcoidosis ; medical imaging ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: English
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  • 3
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-01
    Description: Canadian Pharmaceutical Scientists have a rich history of ground-breaking research in pharmacokinetics and drug metabolism undertaken throughout its Pharmacy and Medical Schools and within the Pharmaceutical and biotechnology industry. The principle of drug Absorption, Distribution, Metabolism and Excretion (ADME) is the foundational basis of rationale drug-design, and pharmacotherapy. The study of ADME and its descriptive quantitative analysis is the basis of pharmacokinetics. Pharmacokinetics is fundamental in the development of a new chemical entity into a marketable product and is essential in understanding the bioavailability, bioequivalence and biosimilarities of drugs. Pharmacokinetics and drug development studies facilitate an understanding of organ-based functionality. Population pharmacokinetic variability and the modeling of drug concentrations has significant utility in translating individual response in a target patient population. This special issue serves to highlight and capture the contemporary progress and current landscape of pharmacokinetics and drug metabolism within the prevailing Canadian context. We invite articles on all aspects of Pharmacokinetics and Drug Metabolism studies highlighting the world-class research currently undertaken in Canada for this special issue.
    Keywords: RM1-950 ; Pharmaceutical Sciences ; Canada ; Drug Metabolism ; Pharmacology ; Drug Delivery ; Pharmacokinetics ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 4
    Publication Date: 2024-04-01
    Description: The year 2017 marks the 20th anniversary of the molecular cloning of the long sought-after capsaicin receptor, now known as TRPV1 (Transient Receptor Potential Vanilloid 1). This seminal discovery has opened up a “hot” new field of basic research and launched drug discovery efforts into the large family (by the latest count, 28 mammalian members and 27 in humans) of TRP ion channels. Indeed, it took less than a decade for the first potent, small molecule TRPV1 antagonists to enter phase 1 clinical trials, closely followed by TRPA1 and TRPM8 antagonists. The literature on TRP channels is immense. TRPV1 alone is a keyword in over 5000 publications searchable in PubMed. Clearly, it is not possible to capture the entire literature in a single thematic issue. Consequently, the selection of articles presented in this book represents a sampling of the literature, and is admittedly subjective. We tried to survey the wide range of human diseases in which TRP channels have been implicated, ranging from chronic pain through asthma and diabetes to cancer, and highlight the channels that appear to hold the greatest promise for therapeutic targeting. With this book, we hope to convince readers that TRP channels constitute a formidable family of potential therapeutic targets that will likely continue to demand attention.
    Keywords: RM1-950 ; resiniferatoxin ; pain ; TRPA1 ; TRPV3 ; TRPV1 ; TRP channels ; TRPM2 ; respiratory disorders ; permanent analgesia ; capsaicin ; TRPM7 ; cancer ; TRPM8 ; diabetes ; obesity ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 5
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually partitioned into three distinct regions, known as classes I, II, and III, which, to varying extents, can be found conserved in nonmammalian jawed vertebrates, such as bony fish, amphibians, and bird lineages. The MHC gene region is characterized particularly by the expression of class I and class II glycoproteins that bind peptides derived from intracellular or extracellular antigens to circulating T-cells. While this expressed antigenic specificity remains the predominant interest with respect to MHC function and polymorphism in a population, a broader concept has emerged that examines the MHC as a multifunctional polymorphic controller that facilitates and regulates genome diversity with a much greater array of functions and effects than just MHC-restricted antigen recognition. This volume of 19 reprints presented by various experts and collected from the Special Issue of Cells on “MHC in Health and Disease” covers a broad range of topics on the genomic diversity of the MHC regulatory system in various vertebrate species, including MHC class I, II, and III genes; innate and adaptive immunity; neurology; transplantation; haplotypes; infectious and autoimmune diseases; fecundity; conservation; allelic lineages; and evolution. Taken together, these articles demonstrate the immense complexity and diversity of the MHC structure and function within and between different vertebrate species.
    Keywords: QH301-705.5 ; Q1-390 ; HCP5 ; n/a ; camels ; MHC ; STK19 ; major histocompatibility complex ; human papillomavirus (HPV) ; T-cell receptor ; T1DGC ; bottleneck ; micro-mini-pigs ; life history ; computational analysis ; hepatocellular carcinoma ; phase ; Bactrian camel ; NSDK ; melanoma ; antigen ; autoimmune disease ; RD ; selection ; disease resistance ; autoimmunity ; ancestral haplotype ; Ski complex ; DXO ; high-throughput sequencing ; conservation genetics ; SVA ; lncRNA ; ankylosing spondylitis ; MHC genes ; viral peptides ; competing endogenous RNA (ceRNA) ; astrogliosis ; birds ; long-fragment super haplotype ; SNP ; RLR ; HLA polymorphism ; 5??3? RNA decay ; expression ; 3??5? mRNA turnover ; orthology ; long-read sequencing ; disease association ; dromedary ; polyomavirus ; MHC-II-associated sperm-egg recognition ; experimental medicine ; single nucleotide polymorphism (SNP) ; fish ; SKIV2L ; production trait ; molecular dynamics simulation ; Macaca fascicularis ; human endogenous retrovirus (HERV) ; concerted evolution ; polymorphism ; Old World camels ; MHC polymorphism ; protocol ; nonclassical ; gene duplication ; microglial reaction ; human leukocyte antigen-E ; SKI2W ; quantitative trait loci (QTL) studies ; antiviral immunity ; human immunodeficiency virus (HIV) ; founder effect ; giant panda ; domain movements ; BK virus ; promoter-proximal transcriptional pause ; type 1 diabetes (T1D) ; RP1 ; miR1236 ; KIR ; synaptic covering ; swine leukocyte antigen ; cynomolgus macaque ; HLA ; kidney transplantation ; ?2m knockout mice ; DOM3Z ; interferon ? ; ethnic populations in China ; ecology ; KIR–HLA pairs ; exosomes ; major histocompatibility complex (MHC) ; MHC-I-based mother-fetus recognition ; RNA quality control ; autoimmune diseases ; NELF-E ; haplotype ; genetic drift ; evolution ; nonhuman primate models ; HLA-B27 ; PNS/CNS interface ; risk genes ; pedigree ; MHC-I- and MHC-II-dependent inter-individual recognition ; regulation ; crested ibis ; reproductive performance ; nephropathy ; cancer ; nuclear kinase ; trichohepatoenteric syndrome ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 6
    Publication Date: 2024-04-11
    Description: In recent years, entropy has been used as a measure of the degree of chaos in dynamical systems. Thus, it is important to study entropy in nonlinear systems. Moreover, there has been increasing interest in the last few years regarding the novel classification of nonlinear dynamical systems including two kinds of attractors: self-excited attractors and hidden attractors. The localization of self-excited attractors by applying a standard computational procedure is straightforward. In systems with hidden attractors, however, a specific computational procedure must be developed, since equilibrium points do not help in the localization of hidden attractors. Some examples of this kind of system are chaotic dynamical systems with no equilibrium points; with only stable equilibria, curves of equilibria, and surfaces of equilibria; and with non-hyperbolic equilibria. There is evidence that hidden attractors play a vital role in various fields ranging from phase-locked loops, oscillators, describing convective fluid motion, drilling systems, information theory, cryptography, and multilevel DC/DC converters. This Special Issue is a collection of the latest scientific trends on the advanced topics of dynamics, entropy, fractional order calculus, and applications in complex systems with self-excited attractors and hidden attractors.
    Keywords: TA1-2040 ; T1-995 ; S-Box algorithm ; empirical mode decomposition ; service game ; existence ; hyperchaotic system ; static memory ; complex-variable chaotic system ; neural network ; fractional-order ; permutation entropy ; adaptive approximator-based control ; BOPS ; Bogdanov Map ; complex systems ; Thurston’s algorithm ; parameter estimation ; fractional discrete chaos ; full state hybrid projective synchronization ; self-excited attractor ; stability ; PRNG ; inverse full state hybrid projective synchronization ; entropy measure ; chaos ; chaotic flow ; multistable ; core entropy ; multiscale multivariate entropy ; multistability ; new chaotic system ; strange attractors ; chaotic systems ; spatial dynamics ; spectral entropy ; resonator ; stochastic (strong) entropy solution ; multichannel supply chain ; Hubbard tree ; approximate entropy ; circuit design ; coexistence ; sample entropy ; chaotic maps ; chaotic map ; Gaussian mixture model ; entropy ; laser ; Non-equilibrium four-dimensional chaotic system ; multiple attractors ; projective synchronization ; hidden attractors ; hidden attractor ; chaotic system ; entropy analysis ; self-excited attractors ; multiple-valued ; self-reproducing system ; implementation ; unknown complex parameters ; optimization methods ; image encryption ; generalized synchronization ; uncertain dynamics ; fractional order ; nonlinear transport equation ; external rays ; Lyapunov exponents ; inverse generalized synchronization ; fixed point ; uniqueness ; electronic circuit realization ; synchronization ; Hopf bifurcation ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 7
    Publication Date: 2023-12-20
    Description: The representation of the Earth's surface in global monitoring and forecasting applications is moving towards capturing more of the relevant processes, while maintaining elevated computational efficiency and therefore a moderate complexity. These schemes are developed and continuously improved thanks to well instrumented field-sites that can observe coupled processes occurring at the surface–atmosphere interface (e.g., forest, grassland, cropland areas and diverse climate zones). Approaching global kilometer-scale resolutions, in situ observations alone cannot fulfil the modelling needs, and the use of satellite observation becomes essential to guide modelling innovation and to calibrate and validate new parameterization schemes that can support data assimilation applications. In this book, we review some of the recent contributions, highlighting how satellite data are used to inform Earth surface model development (vegetation state and seasonality, soil moisture conditions, surface temperature and turbulent fluxes, land-use change detection, agricultural indicators and irrigation) when moving towards global km-scale resolutions.
    Keywords: Q1-390 ; direct and inverse methods ; absorption coefficient ; emissivity ; land-surface model ; n/a ; variational retrieval ; temporal autocorrelation ; Bayesian bias correction ; hyperspectral ; infrared ; BRDF ; satellite rainfall ; MCD43C1 ; penetration depth ; RTTOV ; earth-observations ; earth system modelling ; representative depth ; land ; Changjiang (Yangtze) estuary ; CDOM ; soil moisture ; surface ; Maqu network ; surface soil moisture ; MODIS ; soil effective temperature ; GOCI ; microwave remote sensing ; rain gauge ; QAA inversion ; broadband emissivity ; radiation ; surface parameters ; satellite data ; East Africa ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
    Language: English
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  • 8
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: We invite you to contribute to a Special Issue of Nutrients, entitled “Dietary Supplements”. The purpose of this Special Issue is to advance dietary supplement science by presenting commissioned overviews on four nutrients of particular current interest and controversy: Vitamin D, iodine, iron, and omega-3 fatty acids. To supplement these contributions, we welcome the submission of manuscripts describing original research or providing systematic reviews related to various issues in dietary supplement science. Manuscripts across a broad range of topics will be considered, but we are particularly interested in manuscripts that address the following areas: • Health effects, both positive and negative, of single nutrients, such as vitamin D, iodine, iron, and omega-3 fatty acids, with an emphasis on human studies. • Human clinical trials of dietary supplement use • Motivations for and prevalence of the use of dietary supplements • Mechanisms of action of nutrients and other bioactive components of dietary supplements. • Biomarkers of nutritional status, especially those measured in human samples. • Development and application of analytical tools for the measurement of bioactive components of dietary supplements. • Databases of dietary supplements' composition for use in improving the assessment of nutrient intake and of the exposure to ingredients present in these products in human populations.
    Keywords: TX341-641 ; food supplements ; bioactives ; dietary supplements ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFC Cultural studies::JFCV Food & society
    Language: English
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  • 9
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-01-31
    Description: The name of Joseph Fourier is also inseparable from the study of the mathematics of heat. Modern research on heat equations explores the extension of the classical diffusion equation on Riemannian, sub-Riemannian manifolds, and Lie groups. In parallel, in geometric mechanics, Jean-Marie Souriau interpreted the temperature vector of Planck as a space-time vector, obtaining, in this way, a phenomenological model of continuous media, which presents some interesting properties.
    Keywords: Q1-390 ; QC1-999 ; entanglement indicators ; generalized uncertainty principle ; Tsallis entropy ; linear entropy ; quantum-classical relationship ; Wigner–Yanase–Dyson skew information ; deep learning ; spinors in quantum and classical physics ; quantum mechanics ; entropy ; original Bell inequality ; Bohmian dynamics ; qudit states ; square integrable ; uncertainty relation ; quantum bound ; uncertainty relations ; foundations of quantum mechanics ; Born probability rule ; Rényi entropy ; energy quantization ; quantum foundations ; Born rule ; measure of classicality ; minimal observable length ; quantum information ; Kochen–Specker theorem ; neuromorphic computing ; bell inequalities ; successive measurements ; Gleason theorem ; continuous variables ; quantum memory ; perfect correlation/anticorrelation ; quantum trajectory ; quantum computing ; high performance computing ; Quantum Hamilton-Jacobi Formalism ; quantum uncertainty
    Language: English
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  • 10
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: This Special Issue of International Journal of Molecular Sciences (IJMS) is dedicated to the mechanisms mediated at the molecular and cellular levels in response to adverse genomic perturbations and DNA replication stress. The relevant proteins and processes play paramount roles in nucleic acid transactions to maintain genomic stability and cellular homeostasis. A total of 18 articles are presented which encompass a broad range of highly relevant topics in genome biology. These include replication fork dynamics, DNA repair processes, DNA damage signaling and cell cycle control, cancer biology, epigenetics, cellular senescence, neurodegeneration, and aging. As Guest Editor for this IJMS Special Issue, I am very pleased to offer this collection of riveting articles centered on the theme of DNA replication stress. The blend of articles builds upon a theme that DNA damage has profound consequences for genomic stability and cellular homeostasis that affect tissue function, disease, cancer, and aging at multiple levels and through unique mechanisms. I thank the authors for their excellent contributions, which provide new insight into this fascinating and highly relevant area of genome biology.
    Keywords: QH301-705.5 ; Q1-390 ; Werner Syndrome ; n/a ; A549 cells ; epigenetic ; neurodegeneration ; Genome integrity ; adaptation ; cellular senescence ; genome instability ; Werner Syndrome Protein ; lipofuscin ; cell cycle checkpoints ; exonuclease 1 ; template-switching ; energy metabolism ; mutation frequency ; DNA replication ; fork regression ; motor neuron disease ; Microsatellites ; Alzheimer’s disease ; chromatin remodeler ; repair of DNA damage ; AP site analogue ; mutagens ; replication timing ; Thermococcus eurythermalis ; nucleolar stress ; gene expression ; mutations spectra ; origin firing ; Fanconi Anemia ; superfamily 2 ATPase ; DNA translocation ; DNA repair ; SSB signaling ; homologous recombination ; common fragile sites ; 8-chloro-adenosine ; replication ; genome stability ; mutagenicity ; fork reversal ; multiple sclerosis ; non-B DNA ; protein stability ; heterogeneity ; ubiquitin ; SenTraGorTM (GL13) ; replication restart ; EdU ; ?-arrestin ; NER ; aging ; SSB end resection ; oxidative stress ; ATR ; dormant origins ; R loops ; DNA damage response ; Difficult-to-Replicate Sequences ; DNA double-strand repair ; endonuclease IV ; ALS ; double strand break repair ; premature aging ; replication stress ; EXO1 ; POL? ; translesion synthesis ; strand displacements ; G2-arrest ; DNA replication pattern ; SSB repair ; genome integrity ; G protein-coupled receptor kinase interacting protein 2 (GIT2) ; MMR ; replicative stress ; senolytics ; spacer ; interactome ; ATR-Chk1 DDR pathway ; C9orf72 ; replication fork restart ; translesion DNA synthesis ; DNA damage ; mismatch repair ; DNA replication stress ; DNA helicase ; Polymerase kappa ; DNA fiber assay ; H1299 cells ; TLS ; APE2 ; ageing ; cell death ; chromosome ; TopBP1 ; barley ; clock proteins ; post-translational modification ; 8-oxoG ; S phase ; ataxia telangiectasia mutated (ATM) ; G protein-coupled receptor (GPCR) ; Polymerase eta ; cancer ; G protein-coupled receptor kinase (GRK) ; helicase ; genomic instability ; Parkinson’s disease ; nucleotide excision repair ; SupF ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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