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    Pleiotropic Action of Selenium in the Prevention and Treatment of Cancer, and Related Diseases (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2024-04-05
    Beschreibung: This book will cover topics related to the preparation and use of heterogeneous catalytic systems for the transformation of renewable sources, as well as of materials deriving from agro-industrial wastes and by-products. At the same time, the ever-increasing importance of bioproducts, due to the acceptance and request of consumers, makes the upgrade of biomass into chemicals and materials not only an environmental issue, but also an economical advantage.
    Schlagwort(e): QH301-705.5 ; Q1-390 ; isoselenourea ; malignant ; chemotherapeutics ; epigenetics ; antitumor activity ; methylseleninic acid ; mTOR inhibitors ; tumor heterogeneity ; hypoxia ; ER stress ; melanoma ; EMT ; lipid peroxidation ; immune evasion ; hypoxia-inducible factors (HIFs) ; selenium-binding protein 1 ; glutathione ; DNA damage ; hSP56 ; apoptosis ; tocopherol ; anticancer ; viability ; SELENBP1 ; selenium ; clear-cell renal cell carcinoma microRNAs ; SBP1 ; entosis ; PD-L1 ; miRNA ; cancer stem cells ; cell plasticity ; disease ; clear cell renal cell carcinoma ; HIF ; head and neck cancer ; selenium species ; VEGF ; STAT3 ; hypoxia-inducible factor ; methylselenocysteine ; anticancer agent ; Se-containing nanoparticles ; DNA damage and repair ; radiation ; seleno-l-methionine ; cancer ; tumor microenvironment ; methylselenoesters ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Sprache: Englisch
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    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    Biological Potential and Medical Use of Secondary Metabolites (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2024-04-05
    Beschreibung: Many macro and micro species, from terrestrial and aquatic environments, produce structurally unique compounds and, in many countries, still are the primary sources of medicines. In fact, secondary metabolites are an important source of chemotherapeutic agents but are also lead compounds for synthetic modification and the optimization of biological activity. Therefore, the exploitation of secondary metabolites, or their inspired synthetic compounds, offers excellent opportunities for the pharmaceutical industry. This Medicines Special Issue focuses on the great potential of secondary metabolites for therapeutic application. The Special Issue contains 16 articles reporting relevant experimental results, and an overview of bioactive secondary metabolites, their biological effects, and new methodologies that improve and accelerate the process of obtained lead compounds with regard to new drug development. We would like to thank all 83 authors, from all over the world, for their valuable contributions to this Special Issue.
    Schlagwort(e): QD1-999 ; Q1-390 ; antitumor ; triterpenoids ; seaweeds ; diterpenes ; Boswellia ; antioxidant activity ; antiplasmodial ; Maytenus chiapensis ; phenolic derivatives ; secondary metabolites ; medicinal applications ; Malus x domestica ; pectin ; cytotoxic activity ; xanthine oxidase ; phytochemistry ; antioxidant ; Scabiosa ; sugars ; sargaquinoic acid ; pentacyclic triterpenoids ; analysis ; antimicrobial and anticancer activity ; iridoids ; Tuscany ; GC-MS ; (-)-rabdosiin ; kratom ; plant defense ; cembranoids ; tingenone ; deoxypodophyllotoxin ; anticancer ; pristimerin ; inflammation ; boswellic acids ; plants ; anti-inflammatory ; legalization ; Mitragyna speciosa ; Ocimum sanctum ; cordycepin ; cytotoxic ; medicine ; Artemisia species ; antimicrobial activity ; lignans ; Artemisia vachanica ; Cordyceps militaris ; frankincense ; ancient varieties ; sargahydroquinoic acid ; Tajikistan ; antiSMASH ; ABTS ; polyphenols ; therapeutics ; infectious diseases ; antibacterial ; nutraceutics ; total phenolics ; LC-MS/MS ; innate immunity ; HPLC-PAD ; sarganaphthoquinoic acid ; biosynthetic gene clusters ; DPPH ; EGCG ; cneorubenoids ; PPAR-? ; bowel diseases ; amentoflavone ; molecular docking ; sargachromenoic acid ; cannabinoids ; flavonoids ; essential oils ; TCM ; HPLC-PDA ; ascorbic acid ; antioxidants ; Lamiaceae ; nanoemulsion ; malaria ; therapeutic uses ; quinonemethide triterpenoids ; artemisinin ; natural products ; biological activities ; FRAP ; toxicology ; defensins ; Celastraceae ; cannabis ; vector control ; Juniperus ; analytical determination ; thema EDItEUR::P Mathematics and Science::PN Chemistry
    Sprache: Englisch
    Format: image/jpeg
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    Anticancer Drugs (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2024-04-05
    Beschreibung: The past decades have seen major developments in the understanding of the cellular and molecular biology of cancer. Significant progress has been achieved regarding long-term survival for the patients of many cancers with the use of tamoxifen for treatment of breast cancer, treatment of chronic myeloid leukaemia with imatinib, and the success of biological drugs. The transition from cytotoxic chemotherapy to targeted cancer drug discovery and development has resulted in an increasing selection of tools available to oncologists. In this Special Issue of Pharmaceuticals, we highlight the opportunities and challenges in the discovery and design of innovative cancer therapies, novel small-molecule cancer drugs and antibody–drug conjugates, with articles covering a variety of anticancer therapies and potential relevant disease states and applications. Significant efforts are being made to develop and improve cancer treatments and to translate basic research findings into clinical use, resulting in improvements in survival rates and quality of life for cancer patients. We demonstrate the possibilities and scope for future research in these areas and also highlight the challenges faced by scientists in the area of anticancer drug development leading to improved targeted treatments and better survival rates for cancer patients.
    Schlagwort(e): QD1-999 ; Q1-390 ; graphene oxide ; indole ; androgens ; cyclooxygenase-2 ; cyclooxygenase-1 ; heteropolysaccharide ; drug conjugation ; drug delivery ; ellipticine ; chemical linker ; oesophageal cancer ; antiproliferative activity ; topoisomerase II ; ?-lactam ; DSD ; antibody ; topoisomerase inhibitors ; magnetic targeting ; cisplatin resistance ; steroidogenesis ; [18F]FDG PET/CT ; heterocyclic chemistry ; dehydroepiandrosterone ; antimitotic ; 3-vinylazetidin-2-ones ; glioblastoma ; and cancer therapy ; intestinal mucositis ; Combretastatin A-4 ; metabolism ; anti-cancer drugs ; maghemite ; COX-1 inhibitor ; anticancer ; CYP17A1 ; conjugate and hybrid drugs ; inflammation ; snticancer drugs ; P450c17 ; tumorigenesis ; cisplatin ; biomarker profiling ; cancer drug design ; tubulin ; cytochrome P450 ; 5-fluorouracil ; prostate cancer ; abiraterone ; NCI screen ; radiation ; cancer immunotherapy ; microtubule targeted drugs ; cancer ; treatment resistance ; thema EDItEUR::P Mathematics and Science::PN Chemistry
    Sprache: Englisch
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    Standort Signatur Erwartet Verfügbarkeit
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