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  • Books  (86)
  • Cham :Springer International Publishing :  (60)
  • Hanover, NH : U.S. Army Cold Regions Research and Engineering Laboratory  (26)
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  • Books  (86)
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  • 1
    Online Resource
    Online Resource
    Forest Entomology and Pathology : Volume 1: Entomology (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Zoology. ; Plant diseases. ; Forestry. ; Geology. ; Zoology. ; Plant Pathology. ; Forestry. ; Geology.
    Description / Table of Contents: Section I: Introduction to Forest Entomology -- 1. Introduction to and the Importance of Insects -- 2. Form and Function -- 3. Forest Arthropod Biodiversity -- 4. Insect Ecology -- 5. Forest Insect Population Dynamics -- 6. Forest Insect -Natural Enemy Interactions -- 7. Forest Insect-Plant Interactions -- 8. Insects and Forest Succession. Section II: Categories of Insects that Damage Trees -- 9. Foliage Feeders -- 10. Bark Beetles -- 11. Ambrosia Beetles -- 12. Woodborers in Forest Stands -- 13. Sap-sucking Forest Pests -- 14. Gall Formers -- 15. Tip, Shoot, Root and Regeneration Pests -- 16. Insects of Reproductive Structures -- Section III: Management of Forest Insect Pests -- 17. IPM: the Forest Context -- 18. Spatial Dynamics of Forest Insects -- 19. Monitoring and Surveillance of Forest Insects -- 20. Silviculture -- Section IV: Future Prospects -- 21. Forest Health in the Anthropocene -- 22. Climate Change and Forest Insect Pests -- 23. Forest Insect Invasions and their Management.
    Abstract: This open access book will provide an introduction to forest entomology, the principles and techniques of forest insect pest management, the different forest insect guilds/feeding groups, and relevant forest insect pest management case studies. In addition to covering 30% of the earth, forest ecosystems provide numerous timber and non-timber products that affect our daily lives and recreational opportunities, habitat for diverse animal communities, watershed protection, play critical roles in the water cycle, and mitigate soil erosion and global warming. In addition to being the most abundant organisms in forest ecosystems, insects perform numerous functions in forests, many of which are beneficial and critical to forest health. Conversely, some insects damage and/or kill trees and reduce the capacity of forests to provide desired ecosystem services. The target audience of this book is upper-level undergraduate and graduate students and professionals interested in forest health and entomology.
    Type of Medium: Online Resource
    Pages: XII, 810 p. 149 illus., 119 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031115530
    URL: https://doi.org/10.1007/978-3-031-11553-0
    DOI: 10.1007/978-3-031-11553-0
    DDC: 590
    Language: English
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  • 2
    Series available for loan
    Series available for loan
    Investigations performed on the Arctic Ice Dynamics Joint Experiment, March 1971 (1973)
    Hanover, NH : U.S. Army Cold Regions Research and Engineering Laboratory
    Associated volumes
    Details Availability
    Call number: ZSP-202-315
    In: Research report
    Description / Table of Contents: CONTENTS: Preface. - Introduction. - Part 1:Mesoscale strain measurements on the Beaufort Sea pack ice. - Abstract. - Introduction. - Previous work. - Site location. - Results. - Correlation of synoptic aerial photography with measured strains. - Correlation of estimated wind stress and strain. - Conclusions. - Literature cited. - Part II: Structure of a multiyear pressure ridge. - Abstract. - Introduction. - Profiles. - Internal properties. - Largest ridge sail. - Conclusions. - Literature cited. - Part III: Top and bottom roughness of a multiyear ice floe. - Abstract. - Introduction. - Results. - Literature cited. - Part IV:Airphoto analysis of ice deformation in the Beaufort Sea Abstract. - Introduction. - Study area. - Method of analysis. - Ice deformations. - Net deformational changes. - Pressure ridge distribution. - Summary and conclusions. - Literature cited. - Part V: Data on morphological and physical characteristics of sea ice in the Beaufort Sea.
    Description / Table of Contents: Mesoscale strain measurements on the Beaufort Sea pack ice; Structure of a multiyear pressure ridge; Top and bottom roughness of a multiyear ice floe; Airphoto analysis of ice deformation in the Beaufort Sea; Data on morphological and physical characteristics of sea ice in the Beaufort Sea.
    Type of Medium: Series available for loan
    Pages: iii, 66 Seiten , Illustrationen
    Series Statement: Research report / Cold Regions Research and Engineering Laboratory, CRREL, US Army Material Command 315
    URL: http://www.worldcat.org/oclc/1014548
    Language: English
    Branch Library: AWI Library
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  • 3
    Series available for loan
    Series available for loan
    Hydraulic model study of Port Huron ice control structure (1982)
    Hanover, NH : U.S. Army Cold Regions Research and Engineering Laboratory
    Associated volumes
    Details Availability
    Call number: ZSP-201-82/34
    In: CRREL Report, 82-34
    Description / Table of Contents: The ice discharge through an opening in an ice control structure was documented to be a function of the floe size, ice type, ice floe conditions and vessel direction. The model data for the average ice discharge per vessel transit scaled to prototype values compared favorably with data taken at the St. Marys River ice control structure (ICS). The model results of the force measurements were also consistent with data taken at the St. Marys ICS. The dynamic loading conditions were independent of vessel direction. The dynamic loading to the structure using 3 types of ice (plastic, natural and urea-doped) showed a considerable difference in their means and standard deviations. The urea-doped ice was evaluated for dynamic loading conditions, and reasonable peak values of 3 to 5 times the mean load at each measuring position were recorded, independent of vessel direction. It appears that synthetic random ice floes may be used in model studies where ice discharge through an opening in a structure needs to be documented. This study shows the synthetic random ice floe discharge to fall reasonably within the values obtained for natural ice discharge for both rafted and non-rafted ice fields above the ICS. However, the question of whether synthetic ice can be used for analyzing force distributions and dynamic force loading criteria cannot be fully answered at this time because the load distributions of the synthetic and natural floes appear to differ.
    Type of Medium: Series available for loan
    Pages: 68 Seiten , Illustrationen
    Series Statement: CRREL Report 82-34
    URL: https://apps.dtic.mil/docs/citations/ADA123715
    URL: https://hdl.handle.net/11681/9331
    Language: English
    Note: CONTENTS Abstract Preface Introduction Scope of work Ice discharge from Lake Huron into St. Clair River Water velocity profiles at Port Huron Ice conditions Physical model Basis for selection Description Instrumentation Model ice control structure Open water calibration Open water tests Experimental procedures and techniques Ice cover calibration Ice control structure orientation Analysis of ice discharge due to ship transits Natural ice Synthetic ice Forces on the ice control structure Static measurements Dynamic force measurements Potential additional shear stresses Anticipated ice conditions with ICS Conclusions Literature cited Appendix A. Application of model results Appendix B. Suggested additional studies Appendix C. Derivation of ice discharge
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  • 4
    Series available for loan
    Series available for loan
    Model study of Port Huron ice control structure : wind stress simulation (1982)
    Hanover, NH : U.S. Army Cold Regions Research and Engineering Laboratory
    Associated volumes
    Details Availability
    Call number: ZSP-201-82/9
    In: CRREL Report, 82-9
    Description / Table of Contents: This study deals with the distribution of forces along the converging boundaries of the Port Huron, Michigan, region where unconsolidated ice in Lake Huron is held against wind and water stresses. An experimental basin was built to induce uniform shear stress on the model ice cover by flowing water beneath the ice. The boundary segments, which held the ice cover in the region, were instrumented to measure force in the normal and tangential directions. The distribution of normal forces along the boundary was compared with as distribution derived by using a theoretical model. An ice control structure (ICS) was installed in the basin and experiments were conducted to measure the forces on the ICS and the ice release through the opening in the ICS during simulated ship passages. The experimental results are presented in a nondimensional form. In addition, the force per unit length on the ICS and the area of ice released through its opening were estimated for the expected wind conditions at the Port Huron site.
    Type of Medium: Series available for loan
    Pages: v, 27 Seiten , Illustrationen
    Series Statement: CRREL Report 82-9
    URL: https://hdl.handle.net/11681/9347
    Language: English
    Note: CONTENTS Abstract Preface List of symbols Introduction Theoretical models Case 1 Case 2 Case 3 Experimental program Experimental facility Scaling factors Experimental results Analysis of wind data for lower Lake Huron Summary and conclusions Release of ice through the opening of an ICS Ice forces on the ice control structure Ice forces on ice control structure from a large unconsolidated ice cover Literature cited Appendix A. Equation for the stress resultants and velocities of the ice cover Appendix B. Monthly summary of wind data at Port Huron
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  • 5
    Online Resource
    Online Resource
    Translational Neuroscience of Speech and Language Disorders (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Neuroscience.
    Description / Table of Contents: 1. Translational Neuroscience of Speech and Language Disorders: State of the Art. -2. Translational Neuroscience of Aphasia and Adult Language Rehabilitation. -3. Treatment and intervention approaches for the improvement of language abilities in neurodegenerative diseases -- 4. Neural and Genetic Mechanisms of Dyslexia -- 5. The role of memory systems in neurodevelopmental disorders of language -- 6. Transcranial direct current stimulation (tDCS) and Language/Speech: Can patients benefit from a combined therapeutic approach? -- 7. Transcranial Magnetic Stimulation in Aphasia Rehabilitation -- 8. The Cerebellum: A Therapeutic Target in Treating Speech and Language Disorders -- 9. Navigated rTMS for Mapping the Language Network in Preoperative Settings: Current Status and Future Prospects -- 10. Presurgical Language fMRI in Epilepsy: An Introduction -- 11. Lesion-symptom mapping in speech and language disorders: a translational perspective.
    Abstract: This edited volume provides the first presentation of the state-of-the-art in the application of modern Neuroscience research in predicting, preventing and alleviating the negative sequelae of neurodevelopmental, acquired, or neurodegenerative conditions on speech and language. It brings together contributions from several leading experts in a markedly broad range of disciplines, including Speech and Language Therapy, Neuropsychology and Neurology, but also Neurosurgery, Neuroimaging and Neurostimulation, as well as Engineering and Genetics.
    Type of Medium: Online Resource
    Pages: XVII, 290 p. 18 illus., 8 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030356873
    Series Statement: Contemporary Clinical Neuroscience,
    URL: https://doi.org/10.1007/978-3-030-35687-3
    DOI: 10.1007/978-3-030-35687-3
    DDC: 612.8
    Language: English
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  • 6
    Online Resource
    Online Resource
    Speciesism in Biology and Culture : How Human Exceptionalism is Pushing Planetary Boundaries (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Evolution (Biology). ; Environment. ; History. ; Conservation biology. ; Ecology . ; Ethics. ; Environmental sciences Social aspects. ; Evolutionary Biology. ; Environmental Sciences. ; History. ; Conservation Biology. ; Moral Philosophy and Applied Ethics. ; Environmental Social Sciences.
    Description / Table of Contents: Part I. Biology and Culture -- Chapter 1. Speciesism in Biology and Culture: How Human Exceptionalism is Pushing Planetary Boundaries -- Chapter 2. Race and Human Genomic Variation -- Chapter 3. Science Without Species: Doing Science With Tree-Thinking -- Part II. Culture and History -- Chapter 4. The Colonization of Islands as Microcosms for Human Impacts on an Interplanetary Scale -- Chapter 5. Species, God, and Dominion -- Chapter 6. Symbols and How We Came to be Human -- Part III. Conservation and Law -- Chapter 7. Law and Nature: Human, Nonhuman, and Ecosystem Rights -- Chapter 8. A Phylogenetic Approach to Conservation: Biodiversity and Ecosystem Functioning for a Changing Globe -- Part IV. Sustainability and the Future -- Chapter 9. Energy and Society: Toward a Sustainable Future.
    Abstract: This open access book explores a wide-ranging discussion about the sociopolitical, cultural, and scientific ramifications of speciesism and world views that derive from it. In this light, it integrates subjects across the natural sciences, social sciences, and humanities. The 21st-century western world is anthropocentric to an extreme; we adopt unreasonably self-centered and self-serving ideas and lifestyles. Americans consume more energy resources per person than most other nations on Earth and have little concept of how human ecology and population biology interface with global sustainability. We draw upon religion, popular culture, politics, and technology to justify our views and actions, yet remain self-centered because our considerations rarely extend beyond our immediate interests. Stepping upward on the hierarchy from “racism,” “speciesism” likewise refers to the view that unique natural kinds (species) exist and are an important structural element of biodiversity. This ideology manifests in the cultural idea that humans are distinct from and intrinsically superior to other forms of life. It further carries a plurality of implications for how we perceive ourselves in relation to nature, how we view Judeo-Christian religions and their tenets, how we respond to scientific data about social problems such as climate change, and how willing we are to change our actions in the face of evidence. .
    Type of Medium: Online Resource
    Pages: XVI, 203 p. 28 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030990312
    URL: https://doi.org/10.1007/978-3-030-99031-2
    DOI: 10.1007/978-3-030-99031-2
    DDC: 576.8
    Language: English
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  • 7
    Online Resource
    Online Resource
    Freshwaters and Wetlands of Patagonia : Ecosystems and Socioecological Aspects (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Freshwater ecology. ; Marine ecology. ; Conservation biology. ; Ecology . ; Geography. ; Environment. ; Power resources. ; Freshwater and Marine Ecology. ; Conservation Biology. ; Regional Geography. ; Environmental Sciences. ; Natural Resource and Energy Economics.
    Description / Table of Contents: Intro: Navigating Patagonian freshwaters- and this book -- 1: Are freshwaters wetlands? -- 2: Patagonian Andean lakes and climate change -- 3: Current state and recent changes of glaciers in the Patagonian Andes (35 °S to 55°S) -- 4: Biogeographical patterns of Patagonian freshwater microbiota -- 5: Extreme freshwater ecosystems from Patagonia: The Copahue-Agrio system -- 6: Mercury in aquatic systems of North Patagonia: sources, processes and trophic transfer -- 7: Diversity patterns across aquatic communities from peat bogs -- 8: Hydrologic Systems, water uses and emerging conflicts around freshwater availability in Patagonia -- 9: Land-use effects on aquatic ecosystems: An overview of environmental impacts and tools for ecological assessment -- 10: Patagonian wetlands: vertientes, vegas, mallines,turberas and lagunas -- 11: Fish and fisheries of the Patagonian steppe -- 12: Invasive species: The case of Didymosphenia geminata in Neuquén Province -- 13: Influence of the fish introduction in lakes of the arid Patagonia -- 14: Patagonian cultural limnology: knowledge and water management in Mapuche rural communities -- 15: Political Ecology, water valoration and Water Law deliberation in the Province of Tierra del Nacional de Tierra del Fuego -- 16: Freshwater systems in protected areas in Patagonia -- 17: Amphibians and waterbirds as bridges to conserve aquatic and terrestrial habitat in Patagonia -- 18: Integrated long term conservation strategies to recover the critically endangered Hooded Grebe (Podiceps gallardoi),an endemic waterbird of Austral Patagonia -- Conclusion: Reaching out for the UNDP Sustainable Development Goals in Patagonia.
    Abstract: The Freshwaters of Patagonia adopts a socioecological approach, in which experts from across Patagonia review recent, scientifically rigorous literature and data of their own, thus synthesizing the current knowledge directly relevant to understand the present state and future trends of icefields, freshwater and wetland ecosystems in this region. The book’s organization into three parts provides a studied and comprehensive view on the patterns and processes of the various ecosystems in Patagonia, and describes the sociological aspects of freshwater ecosystems, as well as characterizes the conservation of the freshwater and wetland ecosystems, in Patagonia. The chapters offer a broad, state-of-the-art overview of the current status of glaciers, freshwater and wetland ecosystems of this region, as well as studies of both local and large scale biodiversity patterns, and study cases of extreme and naturally polluted environments.The volume concludes with the current status of Patagonian freshwaters, and discusses the scientific, legal and administrative tools aimed at their sustainable management within the framework of the UNEP Sustainable Development Goals 2030 Agenda. A broad audience of students, scientists, engineers, environmental managers, and policy makers will be interested in this volume.
    Type of Medium: Online Resource
    Pages: XI, 541 p. 104 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031100277
    Series Statement: Natural and Social Sciences of Patagonia,
    URL: https://doi.org/10.1007/978-3-031-10027-7
    DOI: 10.1007/978-3-031-10027-7
    DDC: 577.6
    Language: English
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  • 8
    Online Resource
    Online Resource
    History of Arbovirology: Memories from the Field : Volume I: Personal Reflections (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Virology. ; Medicine Research. ; Biology Research. ; Life sciences. ; Virology. ; Biomedical Research. ; Life Sciences.
    Description / Table of Contents: 1. The Quest for Excellence and the Challenge of Gender Equality in Arbovirology: A Celebration of Women’s Contributions to the Field -- 2. Serendipity and Arboviruses -- 3. The Tapestry of Life: Weaving an Arbovirologist -- 4. Arbovirus and Viral Hemorrhagic Fevers Research Inception in Central and West Africa -- 5. From Bwamba to the Present: The Changing Forest of Arbovirology -- 6. Fighting Dengue, Chikungunya and Japanese Encephalitis -- 7. Chronicles of Hantaviruses: Foundations of Epidemiology and Ecology -- 8. Yellow Fever and Other Viruses in West Africa -- 9. The “Golden Age” of Arbovirology, 1950-1969 -- 10. Twenty-Seven Years of Field Studies on Dengue and Aedes Aegypti in Latin America -- 11. 50 Years of Medical Entomology: Miscellaneous Interesting Findings -- 12. Remembrances of Virology Past -- 13. An Overview of Arbovirology in São Paulo State, Southeastern Brazil: Highlighting the Virus Research Center in Ribeirão Preto City -- 14. An Unplanned Career in Arbovirology.
    Abstract: These books bring together a panel of expert arbovirologists who recall the history of arbovirology from very personal perspectives. In these timely volumes, the authors describe seminal moments in their experiences in the field and how they integrated these findings with lab studies to further clarify the ecology and epidemiology of diverse arboviruses. Authors identify the most pressing questions that remain to be answered, providing a basis for current research and a stimulus to engage those entering the field. Over the last 20 years a generational gap has developed between the giants of arbovirus research and discovery and the new generation. This gap developed due to an ebbing of training and investment in passing the scepter to the next generation, leading to a lack of continuity among the generations that threatens to derail the rich history of virus discovery, field epidemiology and understanding of the richness of diversity that surrounds us. This lack of continuity may have immediate and disastrous consequences for public health when yet to be discovered arboviruses emerge. The purpose of these books is to bridge this gap by providing a historical context for the work being done today and provide continuity between the generations. To this end, the books provide a narrative of the thrill of scientific discovery and excitement of field adventures and lab studies of that generation -- essential reading for every arbovirologist, and highly recommended for all virologists and public health officials, as well as those students considering future research options. Volume I consists of the personal reflections of arbovirologists who played a significant role in the advancement of arbovirology across the globe. Volume II transitions to descriptions of region-specific and virus family-specific perspectives of arbovirology, as well as recollections of the early events of molecular advances and pathogenesis studies.
    Type of Medium: Online Resource
    Pages: XX, 542 p. 258 illus., 200 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031219993
    URL: https://doi.org/10.1007/978-3-031-21999-3
    DOI: 10.1007/978-3-031-21999-3
    DDC: 579.2
    Language: English
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  • 9
    Online Resource
    Online Resource
    Heparanase : From Basic Research to Clinical Applications (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Oncology. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Oncology. ; Biomedical Research.
    Description / Table of Contents: Section 1: Historical Background -- Chapter 1: Mast cell/platelet heparanase/Heparan sulfate biosynthesis and turnover -- Chapter 2: gene cloning/overview -- Chapter 3: gene cloning/melanoma metastasis -- Chapter 4: gene cloning/cancer/immune system -- Chapter 5: heparin/HS modifying enzymes -- Section 2: Crystal Structure/substrate specificity/gene regulation -- Chapter 6: crystal structure -- Chapter 7: molecular dynamics, KKDC peptide -- Chapter 8: Biochemistry/active site -- Chapter 9: substrate specificity -- Chapter 10: gene regulation, promoter/Egr1/methylation -- Chapter 11: SNPs -- polymorphism -- Chapter 12: Splice variants -- Section 3: Cell & tumor biology (general functions & mode of action) -- Chapter 13: Exosomes/heparan sulfate/heparanse -- Chapter 14: Exosomes/drug resistance -- Chapter 15: Nuclear heparanse/transcriptional activity -- Chapter 16: Non-Enzymatic functions/Signal transduction/cellular trafficking/autophagy -- Chapter 17: Heparan sulfate/stem cells/inflammation -- Chapter 18: Danger signals/HS/platelet heparanse -- Chapter 19: Heparanse/Intergrins/Melanoma -- Section 3: Immune Cells/Immnuno-Modulation -- Chapter 20: Heparain. Heparanse and Selectins in Cancer Metastasis and Inflamation --- Chapter 21: Trans-Endithelial Migration, Lymphocytes, Neutrophils/T-cells --Chapter 22: Macrophages, dendritic cells, autoimmunity -- Chapter 23: Macrophages, Heparanse and the tumor microenvironment, neutralizing antibodies -- Chapter 24: NK Cells -- Section 4: Cancer (heparanse in specific types of cancer) -- Chapter 25: Myeloma, inhbition, drug resistance -- Chapter 26: Breast Cancer/Pancreatic Cancer/Cancer and Inflammation -- Chapter 27: Brain Metastasis/MIR-1258 -- Chapter 28: Gastric cancer/immunization -- Chapter 29: Head and Neck Cancer -- Chapter 30: Glioma -- Chapter 31: Sarcoma -- Section 5: Inhibitors/clinical trails/cancer -- Chapter 32: Chemistry/synthesis of heparanse inhibitors PI-88, PG -- Chapter 33: PG series/biology/Tumor models and clinical trial -- Chapter 34:Chemically modified heparins/Heparin mimetics -- Chapter 35: Medicinal Chemistry (Ronesparstat/small molecules/clinical trials) - Section 6: Other indications/diseases -- Chapter 36: IBD/inflammation and cancer/diabetes/obesity -- Chapter 37: Immune Diabetes -- Chapter 38 Inflammation, Sepsis/Amyloidosis -- Chapter 39: Kidney dysfunction -- Chapter 40: Fibrosis -- Chapter 41: Viral infection -- Chapter 42: Cariomyocytes/Endothelial cell-cardiomyocyte crosstakl in diabetic cariomyopathy -- Chapter 43: Eye research -- Chapter 44: atheroscelerosis, nuclear localization -- Chapter 45: Yona Nadir (coagulation/tissue factor) -- Section 7: Heparanse-2 (Hpa2) -- Chapter 46: Hpa2 gene cloning -- Chapter 47: UFS -- urofacial syndrome/peripheral neuropathy -- Chapter 48: Hpa2: tumor suppressor.
    Abstract: Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.
    Type of Medium: Online Resource
    Pages: XVIII, 885 p. 168 illus., 107 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030345211
    Series Statement: Advances in Experimental Medicine and Biology, 1221
    URL: https://doi.org/10.1007/978-3-030-34521-1
    DOI: 10.1007/978-3-030-34521-1
    DDC: 571.978
    Language: English
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  • 10
    Online Resource
    Online Resource
    Proteostasis and Disease : From Basic Mechanisms to Clinics (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Cytology. ; Neurosciences. ; Immunology. ; Medicine Research. ; Biology Research. ; Cancer. ; Cell Biology. ; Neuroscience. ; Immunology. ; Biomedical Research. ; Cancer Biology.
    Description / Table of Contents: Part I. Cancer -- Ubiquitin-Regulated Cell Proliferation and Cancer -- Ubiquitin, SUMO, and Nedd8 as Therapeutic Targets in Cancer -- The Proteasome System in Health and Disease -- Proteostasis Dysregulation in Pancreatic Cancer -- Divergent Modulation of Proteostasis in Prostate Cancer -- Resistance to the Proteasome Inhibitors: Lessons from Multiple Myeloma and Mantle Cell Lymphoma -- Part II. Neurodegeneration -- Altered Proteostasis in Neurodegenerative Tauopathies -- The Ubiquitin System in Alzheimer’s Disease -- The Interplay Between Proteostasis Systems and Parkinson’s Disease -- Machado–Joseph Disease: A Stress Combating Deubiquitylating Enzyme Changing Sides -- Part III. Infection, Inflammation and Developmental Disorders -- SUMO and Cytoplasmic RNA Viruses: From Enemies to Best Friends -- The Role of Proteostasis in the Regulation of Cardiac Intercellular Communication -- By the Tips of Your Cilia: Ciliogenesis in the Retina and the Ubiquitin-Proteasome System -- TRIM E3 Ubiquitin Ligases in Rare Genetic Disorders -- Part IV. Diet -- We Are What We Eat: Ubiquitin–Proteasome System (UPS) Modulation Through Dietary Products.
    Abstract: This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.
    Type of Medium: Online Resource
    Pages: XII, 348 p. 42 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030382667
    Series Statement: Advances in Experimental Medicine and Biology, 1233
    URL: https://doi.org/10.1007/978-3-030-38266-7
    DOI: 10.1007/978-3-030-38266-7
    DDC: 571.6
    Language: English
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