Publikationsdatum:
1986-05-30
Beschreibung:
For many drugs, only racemic mixtures are available for clinical use. Because different stereoisomers of drugs often cause different physiological responses, the use of pure isomers could elicit more exact therapeutic effects. Differential complexation of a variety of drug stereoisomers by immobilized beta-cyclodextrin was investigated. Chiral recognition and racemic resolution were observed with a number of compounds from such clinically useful classes as beta-blockers, calcium-channel blockers, sedative hypnotics, antihistamines, anticonvulsants, diuretics, and synthetic opiates. Separation of the diastereomers of the cardioactive and antimalarial cinchona alkaloids and of two antiestrogens was demonstrated as well. Three dimensional projections of beta-cyclodextrin complexes of propanolol, which is resolved by this technique, and warfarin, which is not, are compared. These studies have improved the understanding and application of the chiral interactions of beta-cyclodextrin, and they have demonstrated a means to measure optical purity and to isolate or produce pure enantiomers of drugs. In addition, this highly specific technique could also be used in the pharmacological evaluation of enantiomeric drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Armstrong, D W -- Ward, T J -- Armstrong, R D -- Beesley, T E -- RR1081/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1986 May 30;232(4754):1132-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3704640" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Chemical Phenomena
;
Chemistry
;
Cinchona Alkaloids/isolation & purification
;
*Cyclodextrins
;
*Dextrins
;
Propranolol/isolation & purification
;
*Starch
;
*Stereoisomerism
;
Warfarin/isolation & purification
;
*beta-Cyclodextrins
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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