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  • 1
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    Tertiary deep-marine reservoirs of the North Sea region: an introduction (2015)
    Geological Society (of London)
    Details
    Publication Date: 2015-08-22
    Description: Extract The early discovery of the Arbroath Field in 1969, and the Montrose and giant Forties fields in 1970, initiated intensive exploration of the Tertiary deep-marine play in the North Sea region. Numerous subsequent discoveries (Fig. 1), including Frigg (in 1971), Maureen (in 1973), Gannet (in 1973), Andrew (in 1974), Pierce (in 1976), Everest (in 1982), Alba (in 1984), Gryphon (in 1987), Nelson (in 1988), Harding (in 1988), Jotun (in 1994), Siri (in 1995) and Merganser (in 1995), demonstrate the success of this play and the geological diversity of Paleocene and Eocene systems present within the region. Although the North Sea Basin is now considered mature, with Cenozoic reservoirs well along their creaming curve (Vining et al. 2005), recent discoveries (e.g. the Catcher Field in 2010) highlight that potential still remains within intensively explored areas such as the Central North Sea, as well as in the less explored regions such as the Atlantic margin and the Norwegian Sea. The importance of these reservoirs is demonstrated by the large proportion of UK production to which they contribute, amounting to approximately 25% of all production from UK oil fields since 1975 on a barrel of oil equivalent (BOE) basis (Fig. 2). Indeed, over time that proportion has increased from 20% of production in the 1970s and 1980s to 30% from the 1990s. ... This 250-word extract was created in the absence of an abstract.
    Print ISSN: 0305-8719
    Electronic ISSN: 2041-4927
    Topics: Geosciences
    Published by Geological Society (of London)
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  • 2
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    Separation of drug stereoisomers by the formation of beta-cyclodextrin inclusion complexes (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-05-30
    Description: For many drugs, only racemic mixtures are available for clinical use. Because different stereoisomers of drugs often cause different physiological responses, the use of pure isomers could elicit more exact therapeutic effects. Differential complexation of a variety of drug stereoisomers by immobilized beta-cyclodextrin was investigated. Chiral recognition and racemic resolution were observed with a number of compounds from such clinically useful classes as beta-blockers, calcium-channel blockers, sedative hypnotics, antihistamines, anticonvulsants, diuretics, and synthetic opiates. Separation of the diastereomers of the cardioactive and antimalarial cinchona alkaloids and of two antiestrogens was demonstrated as well. Three dimensional projections of beta-cyclodextrin complexes of propanolol, which is resolved by this technique, and warfarin, which is not, are compared. These studies have improved the understanding and application of the chiral interactions of beta-cyclodextrin, and they have demonstrated a means to measure optical purity and to isolate or produce pure enantiomers of drugs. In addition, this highly specific technique could also be used in the pharmacological evaluation of enantiomeric drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Armstrong, D W -- Ward, T J -- Armstrong, R D -- Beesley, T E -- RR1081/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1986 May 30;232(4754):1132-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3704640" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Cinchona Alkaloids/isolation & purification ; *Cyclodextrins ; *Dextrins ; Propranolol/isolation & purification ; *Starch ; *Stereoisomerism ; Warfarin/isolation & purification ; *beta-Cyclodextrins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
    Electronic Resource
    Electronic Resource
    Spontaneous polypeptide formation from amino acyl adenylates in surfactant aggregates (1978)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 100 (1978), S. 4605-4606 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00482a053
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  • 4
    Electronic Resource
    Electronic Resource
    Enzyme and Whole Cell Production of Flavor and Fragrance Compounds (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 542 (1988), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1988.tb25865.x
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  • 5
    Electronic Resource
    Electronic Resource
    Gear selectivity and the conservation of fish (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 37 (1990), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.1990.tb05060.x
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  • 6
    Electronic Resource
    Electronic Resource
    Facile separation of enantiomers, geometrical isomers, and routine compounds on stable cyclodextrin LC bonded phases (1984)
    Springer
    Journal of inclusion phenomena and macrocyclic chemistry 2 (1984), S. 533-545 
    Details
    ISSN: 1573-1111
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The effectiveness of employing stationary phases composed of chemically bonded cyclodextrin molecules in the high performance liquid chromatographic separation of a variety of different types of compounds is summarized. Over one hundred compounds, including optical, geometrical, and structural isomers, diastereomers, and epimers were successfully separated from each other via use of beta- or gamma-cyclodextrin bonded phases and aqueous methanolic mobile phases. The mechanism of separation is based upon inclusion complex formation between the compounds being separated and the cyclodextrin molecules bonded to the stationary phase. The effects of temperature, mobile phase composition and flow rate upon the chromatographic selectivity and resolution are described. The results indicate that the cyclodextrin columns may be more versatile, flexible, and effective compared to the conventional normal or reversed phase columns.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00662219
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  • 7
    Electronic Resource
    Electronic Resource
    Enantiomeric separation of unusual secondary aromatic amino acids (1998)
    Springer
    Chromatographia 48 (1998), S. 53-58 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Gas chromatography ; Enantiomeric separation ; Chiral derivatization ; Unusual secondary aromatic amino acids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary High-performance liquid chromatographic and gas chromatographic methods were developed for the separation of unusual secondary aromatic amino acids. Amino acids containing 1,2,3,4-tetrahydroisoquinoline, 1,2,3,4-tetrahydronorharmane-1-carboxylic acid and 1,2,3,4-tetrahydro-3-carboxy-2-carboline moieties were synthetized in racemic or chiral forms. The high-performance liquid chromatography was carried out either on a teicoplanin-containing chiral stationary phase or on an achiral C18 column. In the latter case the diastereomers of the amino acids formed by precolumn derivatization with the chiral reagents 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl isothiocyanate or 1-fluoro-2,4-dinitrophenyl-5-L-alanine amide were separated. The gas chromatographic analyses were based on separation on a Chirasil-L-Val column.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02467516
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  • 8
    Electronic Resource
    Electronic Resource
    Novel prebiotic systems: Nucleotide oligomerization in surfactant entrapped water pools (1977)
    Springer
    Journal of molecular evolution 9 (1977), S. 213-223 
    Details
    ISSN: 1432-1432
    Keywords: Dicyanodiimide ; Nucleotide polymerization ; Reversed micelles ; Compartmentalization ; Thermodynamics of nucleotide polymerization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Oligomerization of 5′-TMP in water pools entrapped by dodecyl-ammonium chloride surfactant aggregates in benzene: hexane in the presence of dicyanodiimide at temperatures ranging from 21°–72° resulted in the formation of linear and cyclic oligonucleotides containing up to pentamers. Effects of temperature, time and surfactants have been examined. Rate constants for the formation of oligomers have been determined at five different temperatures. These data afforded values of ΔH
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01796110
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  • 9
    Electronic Resource
    Electronic Resource
    Comparison of Pure Nicotine- and Smokeless Tobacco Extract-Induced Toxicities and Oxidative Stress (1999)
    Springer
    Archives of environmental contamination and toxicology 37 (1999), S. 434-439 
    Details
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract. The toxicities and oxidative stress-inducing actions of (−)-nicotine and smokeless tobacco extract (STE), containing equivalent amounts of nicotine, were studied. Toxicities were determined by colony formation assays using Chinese hamster ovary (CHO) cells. Results indicated that nicotine is less toxic than smokeless tobacco extract that contained the same amount of nicotine. The generation of reactive oxygen species, following treatment with smokeless tobacco extract and nicotine, was assessed by measurement of changes in glutathione (GSH) and malondialdehyde (MDA) levels. CHO cells (5 × 105 cells/5 ml media) were incubated with 4, 0.8, and 0.08 mg of nicotine and STE containing the same amounts of nicotine. All preparations of smokeless tobacco extract significantly decreased GSH levels and increased MDA generation. However, 0.08 mg of nicotine treatment did not result in a significant change in GSH level, and only 4 mg of nicotine were sufficient to increase MDA generation. Addition of free radical scavenging enzymes, superoxide dismutase (SOD) and catalase (CAT), and an intracellular GSH precursor, N-acetyl-L-cysteine (NAC), replenished the GSH levels in nicotine-treated cells. GSH levels in cells exposed to smokeless tobacco extract containing 4 and 0.8 mg nicotine remained significantly lower than the control with the addition of SOD and CAT. However, co-addition of NAC with smokeless tobacco extract preparations returned the GSH levels to the control level. Lactate dehydrogenase (LDH) activities were measured in the media to establish the membrane damage following exposure to smokeless tobacco extract and nicotine. Treatment of cells with 4 mg nicotine caused a significant increase in LDH activity, which was returned to control level in the presence of the antioxidant enzymes and NAC. Smokeless tobacco extract did not change the LDH activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002449900537
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  • 10
    Electronic Resource
    Electronic Resource
    1997 Chirality Medal (1998)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 10 (1998), S. 281-281 
    Details
    ISSN: 0899-0042
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: No abstract.
    Type of Medium: Electronic Resource
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