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  • American Association for the Advancement of Science (AAAS)  (48)
  • Wiley  (43)
  • Nature Publishing Group (NPG)  (17)
  • Inter-Research  (14)
  • 1
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    A vicious cycle of {beta} amyloid-dependent neuronal hyperactivation (2019)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2019
    Description: 〈p〉β-amyloid (Aβ)–dependent neuronal hyperactivity is believed to contribute to the circuit dysfunction that characterizes the early stages of Alzheimer’s disease (AD). Although experimental evidence in support of this hypothesis continues to accrue, the underlying pathological mechanisms are not well understood. In this experiment, we used mouse models of Aβ-amyloidosis to show that hyperactivation is initiated by the suppression of glutamate reuptake. Hyperactivity occurred in neurons with preexisting baseline activity, whereas inactive neurons were generally resistant to Aβ-mediated hyperactivation. Aβ-containing AD brain extracts and purified Aβ dimers were able to sustain this vicious cycle. Our findings suggest a cellular mechanism of Aβ-dependent neuronal dysfunction that can be active before plaque formation.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Diagnosing Bias in Modeled Soil Moisture/Runoff Coefficient Correlation Using the SMAP Level 4 Soil Moisture Product (2019)
    Wiley
    Details
    Publication Date: 2019
    Description: Abstract The physical parameterization of key processes in land surface models (LSMs) remains uncertain, and new techniques are required to evaluate LSMs accuracy over large spatial scales. Given the role of soil moisture in the partitioning of surface water fluxes (between infiltration, runoff, and evapotranspiration), surface soil moisture (SSM) estimates represent an important observational benchmark for such evaluations. Here, we apply SSM estimates from the NASA Soil Moisture Active Passive Level‐4 product (SMAP_L4) to diagnose bias in the correlation between SSM and surface runoff for multiple Noah‐Multiple Physics (Noah‐MP) LSM parameterization cases. Results demonstrate that Noah‐MP surface runoff parameterizations often underestimate the correlation between prestorm SSM and the event‐scale runoff coefficient (RC; defined as the ratio between event‐scale streamflow and precipitation volumes). This bias can be quantified against an observational benchmark calculated using streamflow observations and SMAP_L4 SSM and applied to explain a substantial fraction of the observed basin‐to‐basin (and case‐to‐case) variability in the skill of event‐scale RC estimates from Noah‐MP. Most notably, a low bias in LSM‐predicted SSM/RC correlation squanders RC information contained in prestorm SSM and reduces LSM RC estimation skill. Based on this concept, a novel case selection strategy for ungauged basins is introduced and demonstrated to successfully identify poorly performing Noah‐MP parameterization cases.
    Print ISSN: 0043-1397
    Electronic ISSN: 1944-7973
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 3
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    Ground-based detection of an extended helium atmosphere in the Saturn-mass exoplanet WASP-69b (2018)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2018
    Description: 〈p〉Hot gas giant exoplanets can lose part of their atmosphere due to strong stellar irradiation, and these losses can affect their physical and chemical evolution. Studies of atmospheric escape from exoplanets have mostly relied on space-based observations of the hydrogen Lyman-α line in the far ultraviolet region, which is strongly affected by interstellar absorption. Using ground-based high-resolution spectroscopy, we detected excess absorption in the helium triplet at 1083 nanometers during the transit of the Saturn-mass exoplanet WASP-69b, at a signal-to-noise ratio of 18. We measured line blueshifts of several kilometers per second and posttransit absorption, which we interpret as the escape of part of the atmosphere trailing behind the planet in comet-like form.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Estimation of chromophoric dissolved organic matter in the Mississippi and Atchafalaya river plume regions using above-surface hyperspectral remote sensing (2011)
    Wiley
    Details
    Publication Date: 2011-02-09
    Description: A method for the inversion of hyperspectral remote sensing was developed to determine the absorption coefficient for chromophoric dissolved organic matter (CDOM) in the Mississippi and Atchafalaya river plume regions and the northern Gulf of Mexico, where water types vary from Case 1 to turbid Case 2. Above-surface hyperspectral remote sensing data were measured by a ship-mounted spectroradiometer and then used to estimate CDOM. Simultaneously, water absorption and attenuation coefficients, CDOM and chlorophyll fluorescence, turbidities, and other related water properties were also measured at very high resolution (0.5–2 m) using in situ, underwater, and flow-through (shipboard, pumped) optical sensors. We separate ag, the absorption coefficient a of CDOM, from adg (a of CDOM and nonalgal particles) based on two absorption-backscattering relationships. The first is between ad (a of nonalgal particles) and bbp (total particulate backscattering coefficient), and the second is between ap (a of total particles) and bbp. These two relationships are referred as ad-based and ap-based methods, respectively. Consequently, based on Lee's quasi-analytical algorithm (QAA), we developed the so-called Extended Quasi-Analytical Algorithm (QAA-E) to decompose adg, using both ad-based and ap-based methods. The absorption-backscattering relationships and the QAA-E were tested using synthetic and in situ data from the International Ocean-Colour Coordinating Group (IOCCG) as well as our own field data. The results indicate the ad-based method is relatively better than the ap-based method. The accuracy of CDOM estimation is significantly improved by separating ag from adg (R2 = 0.81 and 0.65 for synthetic and in situ data, respectively). The sensitivities of the newly introduced coefficients were also analyzed to ensure QAA-E is robust.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 5
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    ASLO StoryTellers: Getting Out of the Convention Center (2019)
    Wiley
    Details
    Publication Date: 2019
    Description: Limnology and Oceanography Bulletin, Volume 28, Issue 2, Page 61-62, May 2019.
    Print ISSN: 1539-607X
    Electronic ISSN: 1539-6088
    Topics: Biology , Geosciences
    Published by Wiley on behalf of The Association for the Sciences of Limnology and Oceanography (ASLO).
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  • 6
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    Variations of the 3-D coronal magnetic field associated with the X3.4-class solar flare event of AR 10930 (2014)
    Wiley
    Details
    Publication Date: 2014-04-28
    Description: The variations of the 3-D coronal magnetic fields associated with the X3.4-class flare of active region 10930 are studied in this paper. The coronal magnetic field data are reconstructed from the photospheric vector magnetograms obtained by the Hinode satellite and using the nonlinear force-free field extrapolation method developed in our previous work (He et al., 2011). The 3-D force-free factor α , 3-D current density, and 3-D magnetic energy density are employed to analyze the coronal data. The distributions of α and current density reveal a prominent magnetic connectivity with strong negative α values and strong current density before the flare. This magnetic connectivity extends along the main polarity inversionline and, is found to be totally broken after the flare. The distribution variation of magnetic energy density reveals the re-distribution of magnetic energy before and after the flare. In the lower space of the modeling volume the increase of magnetic energy dominates, and in the higher space the decrease of energy dominates. The comparison with the flare onset imaging observation exhibits that the breaking site of the magnetic connectivity and site with the highest values of energy density increase coincide with the location of flare initial eruption. We conclude that a cramped positive α region appearing in the photosphere causes the breaking of the magnetic connectivity. A scenario for flare initial eruption is proposed in which the Lorentz force acting on the isolated electric current at the magnetic connectivity breaking site lifts the associated plasmas and causes the initial ejection.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 7
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    Ecological differentiation and local adaptation in two sister species of Neotropical Costus (Costaceae) (2014)
    Wiley
    In: Ecology
    Details
    Publication Date: 2014-08-15
    Description: Ecology, Ahead of Print. Reciprocal transplant experiments have often provided evidence of local adaptation in temperate plants, but few such studies have been conducted in the tropics. To enhance our knowledge of local adaptation in tropical plants, we studied natural populations of two recently diverged Neotropical plant species, Costus allenii and C. villosissimus, in central Panama. We found that these species display a parapatric distribution that reflects local environmental differences on a fine geographic scale: C. allenii is found along ravines in the understory of primary forest, while C. villosissimus is found along forest edges. Light availability was lower in C. allenii habitats, while precipitation and soil moisture were lower in C. villosissimus habitats. We carried out reciprocal transplant experiments with seeds and clones of mature plants to test the hypothesis that the parapatric distribution of these species is due to divergent adaptation to their local habitats. We found strong evidence of local adaptation, i.e., when grown in their "home" sites. each species outperformed the species from an "away" site. Our finding that C. allenii and C. villosissimus are mainly isolated by their microhabitats provides a first step towards understanding the mechanisms of adaptation and speciation in the tropics.
    Print ISSN: 0012-9658
    Electronic ISSN: 1939-9170
    Topics: Biology
    Published by Wiley on behalf of The Ecological Society of America (ESA).
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  • 8
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    Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-08-25
    Description: beta-Amyloid plaques and neurofibrillary tangles (NFTs) are the defining neuropathological hallmarks of Alzheimer's disease, but their pathophysiological relation is unclear. Injection of beta-amyloid Abeta42 fibrils into the brains of P301L mutant tau transgenic mice caused fivefold increases in the numbers of NFTs in cell bodies within the amygdala from where neurons project to the injection sites. Gallyas silver impregnation identified NFTs that contained tau phosphorylated at serine 212/threonine 214 and serine 422. NFTs were composed of twisted filaments and occurred in 6-month-old mice as early as 18 days after Abeta42 injections. Our data support the hypothesis that Abeta42 fibrils can accelerate NFT formation in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gotz, J -- Chen, F -- van Dorpe, J -- Nitsch, R M -- New York, N.Y. -- Science. 2001 Aug 24;293(5534):1491-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland. goetz@bli.unizh.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11520988" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Aged, 80 and over ; Alzheimer Disease/metabolism/*pathology ; Amygdala/*pathology ; Amyloid beta-Peptides/administration & dosage/*metabolism ; Animals ; Brain/*pathology ; Epitopes ; Female ; Fluorescent Antibody Technique ; Humans ; Male ; Mice ; Mice, Transgenic ; Microscopy, Immunoelectron ; Mutation ; Neurofibrillary Tangles/*metabolism/pathology ; Peptide Fragments/administration & dosage/*metabolism ; Phosphorylation ; Plaque, Amyloid/*metabolism/pathology ; Protein Conformation ; Protein Isoforms ; Sex Characteristics ; tau Proteins/chemistry/genetics/immunology/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-07-31
    Description: BRCA1 encodes a tumor suppressor that is mutated in familial breast and ovarian cancers. Here, it is shown that BRCA1 interacts in vitro and in vivo with hRad50, which forms a complex with hMre11 and p95/nibrin. Upon irradiation, BRCA1 was detected in discrete foci in the nucleus, which colocalize with hRad50. Formation of irradiation-induced foci positive for BRCA1, hRad50, hMre11, or p95 was dramatically reduced in HCC/1937 breast cancer cells carrying a homozygous mutation in BRCA1 but was restored by transfection of wild-type BRCA1. Ectopic expression of wild-type, but not mutated, BRCA1 in these cells rendered them less sensitive to the DNA damage agent, methyl methanesulfonate. These data suggest that BRCA1 is important for the cellular responses to DNA damage that are mediated by the hRad50-hMre11-p95 complex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhong, Q -- Chen, C F -- Li, S -- Chen, Y -- Wang, C C -- Xiao, J -- Chen, P L -- Sharp, Z D -- Lee, W H -- CA 30195/CA/NCI NIH HHS/ -- CA 58183/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1999 Jul 30;285(5428):747-50.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, TX 78245, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10426999" target="_blank"〉PubMed〈/a〉
    Keywords: BRCA1 Protein/*metabolism ; Cell Cycle Proteins/*metabolism ; Cell Nucleus/*metabolism ; Cell Survival ; *DNA Damage ; *DNA Repair Enzymes ; DNA-Binding Proteins/*metabolism ; Gamma Rays ; Genes, BRCA1 ; Humans ; Methyl Methanesulfonate/pharmacology ; Mutagens/pharmacology ; Mutation ; *Nuclear Proteins ; Rad51 Recombinase ; Recombination, Genetic ; Transfection ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-02-26
    Description: The Caenorhabditis elegans Bcl-2-like protein CED-9 prevents programmed cell death by antagonizing the Apaf-1-like cell-death activator CED-4. Endogenous CED-9 and CED-4 proteins localized to mitochondria in wild-type embryos, in which most cells survive. By contrast, in embryos in which cells had been induced to die, CED-4 assumed a perinuclear localization. CED-4 translocation induced by the cell-death activator EGL-1 was blocked by a gain-of-function mutation in ced-9 but was not dependent on ced-3 function, suggesting that CED-4 translocation precedes caspase activation and the execution phase of programmed cell death. Thus, a change in the subcellular localization of CED-4 may drive programmed cell death.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, F -- Hersh, B M -- Conradt, B -- Zhou, Z -- Riemer, D -- Gruenbaum, Y -- Horvitz, H R -- New York, N.Y. -- Science. 2000 Feb 25;287(5457):1485-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Biology, 68-425, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10688797" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Substitution ; Animals ; Animals, Genetically Modified ; *Apoptosis ; Apoptosis Regulatory Proteins ; Caenorhabditis elegans/*cytology/embryology/genetics/*metabolism ; *Caenorhabditis elegans Proteins ; Calcium-Binding Proteins/genetics/*metabolism ; *Caspases ; Cysteine Endopeptidases/genetics/metabolism ; Genes, Helminth ; Helminth Proteins/genetics/*metabolism ; Immunohistochemistry ; Mitochondria/metabolism ; Mutation ; Nuclear Envelope/*metabolism ; Phenotype ; Proto-Oncogene Proteins/genetics/*metabolism ; Proto-Oncogene Proteins c-bcl-2 ; Repressor Proteins/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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