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  • 1
    Publication Date: 2001-06-26
    Description: Outer hair cells (OHCs) of the mammalian cochlea actively change their cell length in response to changes in membrane potential. This electromotility, thought to be the basis of cochlear amplification, is mediated by a voltage-sensitive motor molecule recently identified as the membrane protein prestin. Here, we show that voltage sensitivity is conferred to prestin by the intracellular anions chloride and bicarbonate. Removal of these anions abolished fast voltage-dependent motility, as well as the characteristic nonlinear charge movement ("gating currents") driving the underlying structural rearrangements of the protein. The results support a model in which anions act as extrinsic voltage sensors, which bind to the prestin molecule and thus trigger the conformational changes required for motility of OHCs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oliver, D -- He, D Z -- Klocker, N -- Ludwig, J -- Schulte, U -- Waldegger, S -- Ruppersberg, J P -- Dallos, P -- Fakler, B -- DC00089/DC/NIDCD NIH HHS/ -- New York, N.Y. -- Science. 2001 Jun 22;292(5525):2340-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology II, University of Tubingen, 72074 Tubingen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11423665" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Substitution ; Animals ; Anion Transport Proteins ; Anions/pharmacology ; Bicarbonates/*metabolism/pharmacology ; CHO Cells ; Cations/pharmacology ; Cell Membrane/metabolism ; Chlorides/*metabolism/pharmacology ; Cricetinae ; Electric Conductivity ; Electrophysiology ; Hair Cells, Auditory, Outer/*physiology ; Models, Biological ; Mutation ; Patch-Clamp Techniques ; Protein Conformation ; Proteins/chemistry/genetics/*metabolism ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2018
    Description: 〈p〉The surface waters of the Southern Ocean act as a control valve through which climatically important tracers such as heat, freshwater, and CO〈sub〉2〈/sub〉 are transferred between the atmosphere and the ocean. The process that transports these tracers through the surface mixed layer into the ocean interior is known as ocean ventilation. Changes in ocean ventilation are thought to be important for both rapid transitions of the ocean’s global overturning circulation during the last deglaciation and the uptake and storage of excess heat and CO〈sub〉2〈/sub〉 as a consequence of anthropogenic climate change. I show how the interaction between Southern Ocean jets, topographic features, and ocean stratification can lead to rapid changes in Southern Ocean ventilation as a function of wind stress. For increasing winds, this interaction leads from a state in which tracers are confined to the surface mixed layer to a state in which tracers fill the ocean interior. For sufficiently high winds, the jet dynamics abruptly change, allowing the tracer to ventilate a water mass known as Antarctic Intermediate Water in the mid-depth Southern Ocean. Abrupt changes in Antarctic Intermediate Water ventilation have played a major role in rapid climate transitions in Earth’s past, and combined with the results presented here, this would suggest that jet dynamics could play a prominent role in contributing to, or even triggering, rapid transitions of the global climate system.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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  • 3
    Publication Date: 2009-03-07
    Description: Glutamate receptors of the AMPA-subtype (AMPARs), together with the transmembrane AMPAR regulatory proteins (TARPs), mediate fast excitatory synaptic transmission in the mammalian brain. Here, we show by proteomic analysis that the majority of AMPARs in the rat brain are coassembled with two members of the cornichon family of transmembrane proteins, rather than with the TARPs. Coassembly with cornichon homologs 2 and 3 affects AMPARs in two ways: Cornichons increase surface expression of AMPARs, and they alter channel gating by markedly slowing deactivation and desensitization kinetics. These results demonstrate that cornichons are intrinsic auxiliary subunits of native AMPARs and provide previously unknown molecular determinants for glutamatergic neurotransmission in the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwenk, Jochen -- Harmel, Nadine -- Zolles, Gerd -- Bildl, Wolfgang -- Kulik, Akos -- Heimrich, Bernd -- Chisaka, Osamu -- Jonas, Peter -- Schulte, Uwe -- Fakler, Bernd -- Klocker, Nikolaj -- New York, N.Y. -- Science. 2009 Mar 6;323(5919):1313-9. doi: 10.1126/science.1167852.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Physiology II, University of Freiburg, Engesserstrasse 4, 79108 Freiburg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19265014" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/cytology/*metabolism ; Cell Membrane/metabolism ; Glutamic Acid/metabolism ; Immunohistochemistry ; *Ion Channel Gating ; Kinetics ; Membrane Proteins/chemistry/metabolism ; Mice ; Neurons/*metabolism ; Patch-Clamp Techniques ; Protein Subunits/chemistry/metabolism ; Proteomics ; Rats ; Receptors, AMPA/chemistry/*metabolism ; Signal Transduction ; Synapses/metabolism ; *Synaptic Transmission ; Xenopus
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2018-10-04
    Description: The surface waters of the Southern Ocean act as a control valve through which climatically important tracers such as heat, freshwater, and CO 2 are transferred between the atmosphere and the ocean. The process that transports these tracers through the surface mixed layer into the ocean interior is known as ocean ventilation. Changes in ocean ventilation are thought to be important for both rapid transitions of the ocean’s global overturning circulation during the last deglaciation and the uptake and storage of excess heat and CO 2 as a consequence of anthropogenic climate change. I show how the interaction between Southern Ocean jets, topographic features, and ocean stratification can lead to rapid changes in Southern Ocean ventilation as a function of wind stress. For increasing winds, this interaction leads from a state in which tracers are confined to the surface mixed layer to a state in which tracers fill the ocean interior. For sufficiently high winds, the jet dynamics abruptly change, allowing the tracer to ventilate a water mass known as Antarctic Intermediate Water in the mid-depth Southern Ocean. Abrupt changes in Antarctic Intermediate Water ventilation have played a major role in rapid climate transitions in Earth’s past, and combined with the results presented here, this would suggest that jet dynamics could play a prominent role in contributing to, or even triggering, rapid transitions of the global climate system.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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  • 5
    Publication Date: 2009-05-28
    Description: We introduce a simple algorithm to improve existing density surfaces to ensure that the resulting surfaces are as close to neutral as possible. This means the slopes at any point on the surfaces are close to neutral tangent planes – the directions along which layered stirring and mixing occurs – minimizing the fictitious diapycnal diffusivity. Inverse techniques and layered models have been used for decades to understand ocean circulation. The most-used density surfaces are potential density or neutral density surfaces. Both these density surfaces and all others produce a fictitious diapycnal diffusivity to some degree due to the helical nature of neutral trajectories – with the magnitude of this artificial diffusivity in some cases being larger than the values measured in the ocean. Here we show how this error can be reduced by up to four orders of magnitude and therefore becomes insignificant compared to measured values, thus providing surfaces which would produce more accurate results when used for inverse techniques.
    Print ISSN: 1812-0784
    Electronic ISSN: 1812-0792
    Topics: Geosciences
    Published by Copernicus on behalf of European Geosciences Union.
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  • 6
    Publication Date: 2009-06-10
    Print ISSN: 1812-0784
    Electronic ISSN: 1812-0792
    Topics: Geosciences
    Published by Copernicus on behalf of European Geosciences Union.
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  • 7
    Publication Date: 2008-08-29
    Description: We introduce a simple algorithm to improve existing density surfaces to ensure that the resulting surfaces are as close to neutral as possible. This means the slopes at any point on the surfaces are close to neutral tangent planes – the directions along which layered stirring and mixing occurs – minimizing the fictitious diapycnal diffusivity. Inverse techniques and layered models have been used for decades to understand ocean circulation. The most-used density surfaces are potential density or neutral density surfaces. Both these density surfaces and all others produce a fictitious diapycnal diffusivity to some degree due to the helical nature of neutral trajectories – with the magnitude of this artificial diffusivity in some cases being larger than the values measured in the ocean. Here we show how this error can be reduced by up to four orders of magnitude and therefore becomes insignificant compared to measured values, thus providing surfaces which would produce more accurate results when used for inverse techniques.
    Print ISSN: 1812-0806
    Electronic ISSN: 1812-0822
    Topics: Geosciences
    Published by Copernicus on behalf of European Geosciences Union.
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  • 8
    Publication Date: 2006-09-19
    Description: Using a 3-dimensional climate model of intermediate complexity we show that the overturning circulation of the Atlantic Ocean can vary at multicentennial-to-millennial timescales for present-day boundary conditions. A weak and continuous freshwater input into the Labrador Sea pushes the overturning circulation of the Atlantic Ocean into a bi-stable regime, characterized by phases of active and inactive deep-water formation in the Labrador Sea. In contrast, deep-water formation in the Nordic Seas is active during all phases of the oscillations. The actual timing of the transitions between the two circulation states occurs randomly. The oscillations constitute a 3-dimensional phenomenon and have to be distinguished from low-frequency oscillations seen previously in 2-dimensional models of the ocean. A conceptual model provides further insight into the essential dynamics underlying the oscillations of the large-scale ocean circulation. The model experiments indicate that the coupled climate system can exhibit unforced climate variability at multicentennial-to-millennial timescales that may be of relevance for Holocene and future climate variations.
    Print ISSN: 1814-9340
    Electronic ISSN: 1814-9359
    Topics: Geosciences
    Published by Copernicus on behalf of European Geosciences Union.
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  • 9
    Publication Date: 2007-02-07
    Description: Using a 3-dimensional climate model of intermediate complexity we show that the overturning circulation of the Atlantic Ocean can vary at multicentennial-to-millennial timescales for modern boundary conditions. A continuous freshwater perturbation in the Labrador Sea pushes the overturning circulation of the Atlantic Ocean into a bi-stable regime, characterized by phases of active and inactive deep-water formation in the Labrador Sea. In contrast, deep-water formation in the Nordic Seas is active during all phases of the oscillations. The actual timing of the transitions between the two circulation states occurs randomly. The oscillations constitute a 3-dimensional phenomenon and have to be distinguished from low-frequency oscillations seen previously in 2-dimensional models of the ocean. A conceptual model provides further insight into the essential dynamics underlying the oscillations of the large-scale ocean circulation. The model experiments indicate that the coupled climate system can exhibit unforced climate variability at multicentennial-to-millennial timescales that may be of relevance for Holocene climate variations.
    Print ISSN: 1814-9324
    Electronic ISSN: 1814-9332
    Topics: Geosciences
    Published by Copernicus on behalf of European Geosciences Union.
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  • 10
    Publication Date: 2019-04-30
    Description: We introduce a new version of the ocean-sea ice implementation of the Australian Community Climate and Earth System Simulator, ACCESS-OM2. The model has been developed with the aim of being aligned as closely as possible with the fully coupled (atmosphere-land-ocean-sea ice) ACCESS-CM2. Importantly, the model is available at three different horizontal resolutions: a coarse resolution (nominally 1° horizontal grid spacing), an eddy-permitting resolution (nominally 0.25°) and an eddy-rich resolution (0.1° with 75 vertical levels), where the eddy-rich model is designed to be incorporated into the Bluelink operational ocean prediction and reanalysis system. The different resolutions have been developed simultaneously, both to allow testing at lower resolutions and to permit comparison across resolutions. In this manuscript, the model is introduced and the individual components are documented. The model performance is evaluated across the three different resolutions, highlighting the relative advantages and disadvantages of running ocean-sea ice models at higher resolution. We find that higher resolution is an advantage in resolving flow through small straits, the structure of western boundary currents and the abyssal overturning cell, but that there is scope for improvements in sub-grid scale parameterisations at the highest resolution.
    Print ISSN: 1991-9611
    Electronic ISSN: 1991-962X
    Topics: Geosciences
    Published by Copernicus on behalf of European Geosciences Union.
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