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  • 1
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    Bundesministerium für Bildung und Forschung Deutschland
    In:  Geoforschungszentrum Potsdam, Bundesministerium für Bildung und Forschung Deutschland, vol. A 744, pp. 6322, (ISBN 0-521-79203-7)
    Publication Date: 2003
    Keywords: Handbook of geophysics ; Handbook of geology ; Tectonics ; GeodesyY ; Review article ; system ; earth ; geotechnology ; processes ; Baehr ; Bahr
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  • 2
    Publication Date: 2000-03-31
    Description: The maternal determinant Bicoid (Bcd) represents the paradigm of a morphogen that provides positional information for pattern formation. However, as bicoid seems to be a recently acquired gene in flies, the question was raised as to how embryonic patterning is achieved in organisms with more ancestral modes of development. Because the phylogenetically conserved Hunchback (Hb) protein had previously been shown to act as a morphogen in abdominal patterning, we asked which functions of Bcd could be performed by Hb. By reestablishing a proposed ancient regulatory circuitry in which maternal Hb controls zygotic hunchback expression, we show that Hb is able to form thoracic segments in the absence of Bcd.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wimmer, E A -- Carleton, A -- Harjes, P -- Turner, T -- Desplan, C -- New York, N.Y. -- Science. 2000 Mar 31;287(5462):2476-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lehrstuhl Genetik, Universitat Bayreuth, 95447 Bayreuth, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10741965" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Body Patterning ; DNA-Binding Proteins/genetics/*physiology ; Drosophila/*embryology/genetics ; *Drosophila Proteins ; Embryonic Development ; Female ; Gene Expression Regulation, Developmental ; Genes, Insect ; Homeodomain Proteins/genetics/*physiology ; Insect Proteins/genetics/*physiology ; Male ; Mutation ; Phenotype ; Promoter Regions, Genetic ; Thorax/embryology ; Trans-Activators/genetics/*physiology ; Transcription Factors/genetics/*physiology ; Transgenes ; Zinc Fingers ; Zygote/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2008-01-19
    Description: Dietary vitamin A deficiency causes eye disease in 40 million children each year and places 140 to 250 million at risk for health disorders. Many children in sub-Saharan Africa subsist on maize-based diets. Maize displays considerable natural variation for carotenoid composition, including vitamin A precursors alpha-carotene, beta-carotene, and beta-cryptoxanthin. Through association analysis, linkage mapping, expression analysis, and mutagenesis, we show that variation at the lycopene epsilon cyclase (lcyE) locus alters flux down alpha-carotene versus beta-carotene branches of the carotenoid pathway. Four natural lcyE polymorphisms explained 58% of the variation in these two branches and a threefold difference in provitamin A compounds. Selection of favorable lcyE alleles with inexpensive molecular markers will now enable developing-country breeders to more effectively produce maize grain with higher provitamin A levels.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933658/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933658/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harjes, Carlos E -- Rocheford, Torbert R -- Bai, Ling -- Brutnell, Thomas P -- Kandianis, Catherine Bermudez -- Sowinski, Stephen G -- Stapleton, Ann E -- Vallabhaneni, Ratnakar -- Williams, Mark -- Wurtzel, Eleanore T -- Yan, Jianbing -- Buckler, Edward S -- S06-GM08225/GM/NIGMS NIH HHS/ -- SC1 GM081160/GM/NIGMS NIH HHS/ -- SC1 GM081160-01/GM/NIGMS NIH HHS/ -- SC1 GM081160-02/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2008 Jan 18;319(5861):330-3. doi: 10.1126/science.1150255.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Genomic Diversity, Cornell University, Ithaca, NY 14853, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18202289" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Breeding ; Carotenoids/*analysis/metabolism ; Crosses, Genetic ; Cryptoxanthins ; Gene Expression Regulation, Plant ; *Genetic Variation ; Haplotypes ; Intramolecular Lyases/*genetics/metabolism ; Molecular Sequence Data ; Mutagenesis ; Nutritive Value ; Polymorphism, Genetic ; Quantitative Trait Loci ; Xanthophylls/analysis/metabolism ; Zea mays/chemistry/enzymology/*genetics ; beta Carotene/analysis/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2009-08-08
    Description: Maize genetic diversity has been used to understand the molecular basis of phenotypic variation and to improve agricultural efficiency and sustainability. We crossed 25 diverse inbred maize lines to the B73 reference line, capturing a total of 136,000 recombination events. Variation for recombination frequencies was observed among families, influenced by local (cis) genetic variation. We identified evidence for numerous minor single-locus effects but little two-locus linkage disequilibrium or segregation distortion, which indicated a limited role for genes with large effects and epistatic interactions on fitness. We observed excess residual heterozygosity in pericentromeric regions, which suggested that selection in inbred lines has been less efficient in these regions because of reduced recombination frequency. This implies that pericentromeric regions may contribute disproportionally to heterosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McMullen, Michael D -- Kresovich, Stephen -- Villeda, Hector Sanchez -- Bradbury, Peter -- Li, Huihui -- Sun, Qi -- Flint-Garcia, Sherry -- Thornsberry, Jeffry -- Acharya, Charlotte -- Bottoms, Christopher -- Brown, Patrick -- Browne, Chris -- Eller, Magen -- Guill, Kate -- Harjes, Carlos -- Kroon, Dallas -- Lepak, Nick -- Mitchell, Sharon E -- Peterson, Brooke -- Pressoir, Gael -- Romero, Susan -- Oropeza Rosas, Marco -- Salvo, Stella -- Yates, Heather -- Hanson, Mark -- Jones, Elizabeth -- Smith, Stephen -- Glaubitz, Jeffrey C -- Goodman, Major -- Ware, Doreen -- Holland, James B -- Buckler, Edward S -- New York, N.Y. -- Science. 2009 Aug 7;325(5941):737-40. doi: 10.1126/science.1174320.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉United States Department of Agriculture-Agriculture Research Service (USDA-ARS), USA. mcmullenm@missouri.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19661427" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Centromere/genetics ; *Chromosome Mapping ; Chromosomes, Plant/*genetics ; Crosses, Genetic ; Epistasis, Genetic ; Flowers/genetics/growth & development ; *Genetic Variation ; Genome, Plant ; Heterozygote ; Hybrid Vigor ; Inbreeding ; Linkage Disequilibrium ; Phenotype ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci ; *Quantitative Trait, Heritable ; Recombination, Genetic ; Selection, Genetic ; Zea mays/classification/*genetics/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2009-08-08
    Description: Flowering time is a complex trait that controls adaptation of plants to their local environment in the outcrossing species Zea mays (maize). We dissected variation for flowering time with a set of 5000 recombinant inbred lines (maize Nested Association Mapping population, NAM). Nearly a million plants were assayed in eight environments but showed no evidence for any single large-effect quantitative trait loci (QTLs). Instead, we identified evidence for numerous small-effect QTLs shared among families; however, allelic effects differ across founder lines. We identified no individual QTLs at which allelic effects are determined by geographic origin or large effects for epistasis or environmental interactions. Thus, a simple additive model accurately predicts flowering time for maize, in contrast to the genetic architecture observed in the selfing plant species rice and Arabidopsis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Buckler, Edward S -- Holland, James B -- Bradbury, Peter J -- Acharya, Charlotte B -- Brown, Patrick J -- Browne, Chris -- Ersoz, Elhan -- Flint-Garcia, Sherry -- Garcia, Arturo -- Glaubitz, Jeffrey C -- Goodman, Major M -- Harjes, Carlos -- Guill, Kate -- Kroon, Dallas E -- Larsson, Sara -- Lepak, Nicholas K -- Li, Huihui -- Mitchell, Sharon E -- Pressoir, Gael -- Peiffer, Jason A -- Rosas, Marco Oropeza -- Rocheford, Torbert R -- Romay, M Cinta -- Romero, Susan -- Salvo, Stella -- Sanchez Villeda, Hector -- da Silva, H Sofia -- Sun, Qi -- Tian, Feng -- Upadyayula, Narasimham -- Ware, Doreen -- Yates, Heather -- Yu, Jianming -- Zhang, Zhiwu -- Kresovich, Stephen -- McMullen, Michael D -- New York, N.Y. -- Science. 2009 Aug 7;325(5941):714-8. doi: 10.1126/science.1174276.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉U.S. Department of Agriculture (USDA)-Agricultural Research Service (USDA-ARS), USA. esb33@cornell.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19661422" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Chromosome Mapping ; Chromosomes, Plant/genetics ; Epistasis, Genetic ; Flowers/*genetics/growth & development ; Gene Frequency ; Genes, Plant ; Genetic Variation ; Geography ; Inbreeding ; Phenotype ; Polymorphism, Single Nucleotide ; *Quantitative Trait Loci ; Quantitative Trait, Heritable ; Recombination, Genetic ; Time Factors ; Zea mays/*genetics/growth & development/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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