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  • 1
    Electronic Resource
    Electronic Resource
    Studies on the Structure of Glyceryl Ethers and the Glyceryl Ether Phospholipids of Bovine Erythrocytes* (1963)
    s.l. : American Chemical Society
    Biochemistry 2 (1963), S. 630-641 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00904a002
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  • 2
    Electronic Resource
    Electronic Resource
    Acute safety of the CFC-free propellant HFA-134a from a pressurized metered dose inhaler (1995)
    Springer
    European journal of clinical pharmacology 48 (1995), S. 473-477 
    Details
    ISSN: 1432-1041
    Keywords: CFC-free propellant ; HFA-134a ; Salbutamol ; safety ; tolerability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract The acute safety of the alternative chlorofluorocarbon-free (CFC-free) propellant HFA-134a from a pressurized metered-dose inhaler (MDI) was assessed in 12 healthy male subjects according to a double-blind, randomized, crossover design. On each of three consecutive days, cumulative doses of 1, 2, 4, 8 and 16 inhalations were administered 30 min apart from one of three MDIs. The three MDIs contained either the HFA-134a CFC-free system without drug (HFA-Placebo), the CFC-free system with salbutamol sulphate (HFA-Salbutamol), or a conventional CFC propellant mixture without drug (CFC-Placebo). Pulmonary function (FEV1, FEF25–75%), cardiovascular performance (heart rate and blood pressure), objective tremor measurements and serum potassium were measured after each incremental dose. Similar responses for pulmonary function, cardiovascular performance, tremor and serum potassium were observed between the HFA-Placebo and CFC-Placebo groups. No statistically significant difference was seen in change from baseline of any parameter between the two propellant systems. The administration of HFA-Salbutamol produced statistically significant dose-related increases in heart rate, systolic blood pressure and tremor and a significant dose-related decrease in serum potassium; these responses were expected based on cumulative doses of active drug. Blood samples for HFA-134a analysis were collected to measure systemic absorption of this propellant. Levels of HFA-134a between 200 and 700 ng · ml−1 were detected in all subjects given the CFC-free system. This study shows that acute inhalation of HFA-134a in a CFC-free system is as safe as a CFC propellant system. Salbutamol sulphate in the CFC-free system can be delivered in a dose-linear fashion, without any noticeable change in the safety profile of active drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00194337
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of Thyrotropin on Nucleic Acids and Protein Contents of the Thyroid (1963)
    [s.l.] : Nature Publishing Group
    Nature 199 (1963), S. 1203-1204 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The experimental animals were male guinea pigs, weighing 200250 g. All experiments were performed on groups, each group comprising 6 animals. A dose of TSH (Ambinon5, Organon) was given intraperitoneally once a day for 16 days. The animals were killed 24 h after the last injection. Different daily ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1991203a0
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of Thyrotropin on in vivo Iodine Binding in Thyroid Subcellular Fractions   (1963)
    [s.l.] : Nature Publishing Group
    Nature 198 (1963), S. 903-905 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Since protein synthesis and iodination must be considered to be the basic functions of the thyroid, experiments were designed in which the TSH-action on both these processes was followed. These studies comprise determination of protein-bound iodine-131 and quantitative analyses of nucleic acids and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/198903a0
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  • 5
    Electronic Resource
    Electronic Resource
    Headquarter Services and Revealed Factor Abundance (1998)
    Oxford, UK and Boston, USA : Blackwell Publishers Ltd
    Review of international economics 6 (1998), S. 0 
    Details
    ISSN: 1467-9396
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: This paper analyzes how usual measures of revealed factor abundance (RFA), based on trade in merchandise, are affected by the existence of trade in services of intangible assets; trade that is mainly associated with multinational firms. It presents empirical estimates of both usual measures of RFA and new measures that take account of trade in headquarter services for the United States, a country that has a substantial surplus in the recorded components of such trade. It is found that the usual measures underestimate the abundance of highly skilled labor and technological knowledge, and overestimate the abundance of physical capital.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/1467-9396.00124
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  • 6
    Electronic Resource
    Electronic Resource
    Biocompatibility of solid poly (ortho ester) (1997)
    Springer
    Journal of materials science 8 (1997), S. 265-269 
    Details
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract In previous studies poly (ortho ester) (POE) has shown promise as a resorbable device, a hemostatic sealant and as a carrier for drugs in bone surgery. The aim of this study was to evaluate the tissue reactions of solid poly (ortho ester) implanted into both tibiae of 17 rabbits. One half of the rods were sterilized by gamma radiation and the other half by ethylene oxide. The follow-up times were from 1 week to 21 weeks, after which the animals were killed and the bony specimens examined histologically. The connective tissue samples were examined immunohistochemically in order to study the occurrences of two extracellular matrix glycoproteins, tenascin and fibronectin. The results showed that solid poly (ortho ester)s induce a moderate inflammatory reaction for 9 weeks. Tenascin and fibronectin were present in samples from 1 week up to 4 weeks. It was also found that gamma sterilized POE was resorbed at week 7 and ethylene oxide sterilized POE at week 13.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018552010027
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  • 7
    Electronic Resource
    Electronic Resource
    Mixture of ε-caprolactone-lactide copolymer and tricalcium phosphate: a histological and immunohistochemical study of tissue reactions (1999)
    Springer
    Journal of materials science 10 (1999), S. 69-74 
    Details
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract In cranio-maxillofacial surgery, bone transplantation is needed for treatment of bony defects. An autograft, allograft or biomaterial can be used. Autogenous bone grafts are considered to be the best materials available, but there are some disadvantages in their use including donorsite morbidity, need for a second operative site and limited graft supply. A search for new bone-graft materials therefore remains necessary. We prepared a mixture of tricalcium phosphate (TCP), which is a resorbable, non-toxic, osteoconductive ceramic material and ε-caprolactone-lactide copolymer P(ε-CL/DL-LA), a resorbable polymer, and placed it in the dermis and in mandibular bone defects in 13 rabbits. Follow-up times were two, three, seven, eight, 12, 15 and 18 weeks, tissue reactions were assessed, histologically and immunohistochemically. Times of resorption of the material from tissues were reported. We found that the mixture caused a mild inflammatory reaction when placed in bone and severe inflammation when placed in dermis. No highly fluorescent layer of tenascin or fibronectin was found surrounding the implant area. The mixture was excellent to handle and very easy to place into bone defects. The results are promising and have led us to continue development of the mixture. © 1999 Kluwer Academic Publishers
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008912802263
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  • 8
    Electronic Resource
    Electronic Resource
    Internal and external loading as regulators of nutrient concentrations in the agriculturally loaded Lake Pyhäjärvi (southwest Finland) (1997)
    Springer
    Hydrobiologia 345 (1997), S. 3-14 
    Details
    ISSN: 1573-5117
    Keywords: eutrophication ; phosphorus ; bioavailability ; nutrient balance ; agriculture ; models
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract This study assesses the effects of external and internalloading on the nutrient concentrations in an agriculturallyloaded shallow lake. Using 13 years of observations of thelake's input and outflow, we calculated the long-term balancesof Tot-P and Tot-N. A more detailed balance, which includeddissolved nutrients and suspended solids, was estimated for anice-free period of one year. The contribution of the externalload was assessed using a mass-balance model. The internalload was estimated from the nutrient balances and on the basisof sedimentation measurements and bioassays. The drainagebasin of the lake provided most of the external nutrientinput; the remaining load was derived from atmosphericdeposition to the lake. The proportions of river-transported Pand N in dissolved form were 25% and 77%, respectively. Thelake retained 〉80% of the external load. Particulatenutrients settled to the bottom and were probably resuspendedseveral times before permanent sedimentation. Dissolvednutrients were bound by primary producers and a highproportion of dissolved P was removed with the fish catch.Dissolved N was also lost via denitrification. Themass-balance model showed that external loading only partlyregulated the mean annual nutrient concentrations in the lake.The regulation was probably due to internal loading, which washigh despite the efficient net retention of nutrients. Duringthe ice-free period, the temporal variations in nutrientconcentrations were controlled almost solely by internalprocesses, such as resuspension of inorganic and organicbottom matter. Although the internal load of bioavailable Pmay, under favourable conditions, exceed the external load,the mechanism by which bioavailable P is translocated from thebottom sediments to the water could not be fully identified. Abbreviations used in this paper follow the editor'srules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1002958727707
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  • 9
    Electronic Resource
    Electronic Resource
    Ultrastructure of the freeze-dried mouse thyroid gland (1963)
    Springer
    Cell & tissue research 59 (1963), S. 467-478 
    Details
    ISSN: 1432-0878
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Mouse thyroids were preserved for electron microscopy by means of freeze-drying. The tissue specimens were frozen in liquid isopentane, dried at a temperature of −79° C to a pressure of 4×10-5 mm Hg, stained in vacuo with osmium tetroxide vapour at room temperature, and embedded in vacuo in Epon or Vestopal W. The ultrastructure of the freeze-dried thyroid gland was found to be fundamentally similar to that observed after “ordinary” chemical fixation. However, some differences were noticed. Thus the plasma membrane of the lateral cell surfaces appeared to be asymmetrical, its inner dense layer being thicker than the outer one. The mitochondria had a finely undulating contour and a matrix of rather high density. The mitochondrial outer and inner membranes appeared as five-layered structures and comprised three dense and two less dense layers. Small dense granules with an undulating outline and larger, less dense granules with a distinct surface membrane were observed. The intra-cisternal space had a lower density than the extra-cisternal space. 150 Å particles occurred very sparsely. The karyoplasm had a low density and the particulate component of the nucleus was rather scanty. By means of pores in the nuclear envelope the karyoplasm appeared to communicate with the extra-cisternal space. No basement membranes were observed. The appearance of myelin sheaths in freeze-dried specimens seemed to agree well with the picture after chemical fixation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00368721
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  • 10
    Electronic Resource
    Electronic Resource
    Preparation of a novel HALS polypropylene stabilizer (1995)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 33 (1995), S. 2699-2703 
    Details
    ISSN: 0887-624X
    Keywords: radiation ; grafting ; HALS ; reactive processing ; m-isopropenyl-α,α-dimethyl benzyl isocyanate ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The radiation induced graft copolymerization of m-isopropenyl-α,α-dimethyl benzyl iso-cyanate (m-TMI) and styrene onto polypropylene was carried out. The extent of grafting increased with increasing amount of styrene and with increased radiation dose. A graft load of 180% was obtained by immersing a 50 kGy pre-irradiated film in a monomer solution containing 25 mol % m-TMI and 75 mol % styrene. The graft copolymer is suitable for covalently binding nonpolymerizable stabilizers with a suitable nucleophilic moiety. In this work the isocyanate moiety of the graft copolymer was allowed to react with 4-amino-2,2,6,6-tetramethyl piperidine, a hindered amine light stabilizer. Fourier trans-formed infrared spectroscopy confirmed the formation of an urea moiety. © 1995 John Wiley & Sons, Inc.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1995.080331603
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