ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 14 (1978), S. 441-444 
    ISSN: 1432-1041
    Keywords: Bioavailability ; dicoumarol ; eating ; serum concentration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The influence of food intake on the biovailability of dicoumarol from a non-micronized formulation was examined in ten healthy volunteers, by examination of its single-dose kinetics after ingestion of dicoumarol 250 mg with a standardized breakfast and on an empty stomach. Blood samples were collected at regular intervals from 0 to 72 h, and the serum concentration of unmetabolized dicoumarol was determinded by spectrophotometry. Postprandial AUC (area under the curve) values were significantly (p〈0.01) greater than the preprandial figures, the mean increase being 85 per cent. The results suggest that dicoumarol should always be taken with food.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 15 (1979), S. 269-274 
    ISSN: 1432-1041
    Keywords: phenytoin ; food-intake ; bioavailability ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The influence of food intake on the absorption of phenytoin was examined in eight healthy volunteers, by study of single-dose kinetics following ingestion of phenytoin 300 mg either with a standardized breakfast or on an empty stomach. Blood samples were collected at regular intervals from 0 to 48 h, and serum concentrations of unmetabolized phenytoin were determined by gas chromatography. Serum concentrations of the major metabolite of phenytoin, 4-hydroxyphenytoin, were measured by mass fragmentography. Concurrent intake of food and phenytoin appeared to accelerate absorption of the drug from the formulation used, and the peak concentrations were significantly higher (mean increase 40%) in the postprandial than in the preprandial state. As reflected by the AUC (area under the curve), the amount of drug absorbed was increased during postprandial conditions, although the difference only reached borderline significance. It is suggested that phenytoin should always be taken in a defined relation to meals.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 16 (1979), S. 327-330 
    ISSN: 1432-1041
    Keywords: atenolol ; food intake ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The influence of food intake on the bioavailability of the beta-adrenoceptor blocker atenolol was assessed by measurement of its single-dose kinetics in ten healthy volunteers, who took 100 mg both in the fasting state and together with a standardized breakfast. Food intake significantly shortened the time to reach peak concentration (2.7 h vs 1.5 h), but caused a significant reduction in AUC values, the mean decrease being 20%. The elimination half-life was unaffected. Atenolol, which is relatively hydrophilic, is incompletely absorbed in the fasting state, and escapes first-pass metabolism. The present findings indicate that food intake causes further impairment of its absorption, even though the absorption rate may initially be enhanced. This contrasts with previous observations on the more lipophilic beta-adrenoceptor blockers propranolol and metoprolol.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Histochemistry and cell biology 51 (1977), S. 261-268 
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The ultrastructure and cytochemistry of the secretory granules of the male hamster submandibular salivary gland were studied. After fixation in glutaraldehyde followed by osmium tetroxide the granules exhibit a characteristic bipartite substructure, with an electron lucid crescenteric rim and a more dense central core. A differentiation into two regions of the granules could also be visualized in specimens primarily fixed in Millonig's osmium tetroxide or in potassium permanganate. The electron lucid peripheral portion of the membrane bounded secretory granules further displays a strong positive reaction after staining of ultrathin sections with the periodic acid-chromic acid-(PA-CrA)-silver technique. The strong periodate reactivity of the rim relative to the core, suggests a difference in mucin composition of the two granule regions. With the PA-CrA-silver staining technique a positive reaction was also observed within the Golgi apparatus of the acinar cells.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Histochemistry and cell biology 53 (1977), S. 107-116 
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The autonomic innervation of the mouse gallbladder mucosa was studied using histo-and cytochemical methods. In a light microscopic investigation the distribution of acetylcholinesterase (AChE) activity and formaldehyde-induced fluorescence was studied histochemically. Nerve fibres and small varicosities showed concentrations of AChE activity very close to the epithelium in the subepithelial connective tissue. No adrenergic nerves were observed in the mucosa. When using the electron microscope and employing the potassium permanganate fixation/staining technique only one sort of axonal enlargement was encountered, viz. the cholinergic type. These varicosities contained numerous agranular vesicles (500–600 Å in diameter). No varicosities of the adrenergic (dense-cored vesicles) type were observed. Signs of increased secretory activity in the epithelium were observed in the first few minutes after cholinergic stimulation. After repeated in vivo stimulation, there was an almost total depletion of glycoprotein granules, best seen when using the cytochemical PA-CrA-silver technique. The findings suggest that the subepithelial connective tissue and the epithelium of the mouse gallbladder mucosa have a cholinergic innervation.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Histochemistry and cell biology 44 (1975), S. 253-275 
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Die Entwicklung des Gallenblasenepithels des Meerschweinchens folgt einem festgesetzten Terminplan: in der 1. Phase (-30. Embryonaltag, ET) steht die Zellvermehrung im Vordergrund. Die Epithelzellen sind noch relativ klein und undifferenziert. In der 2. Phase (-44. ET) beherrscht die Cytodifferenzierung das Bild. Die Zellen strecken sich, ihre Kerne wandern nach basal, die Zellen bekommen ihre endgültige Gliederung, alle Zellorganellen ihr charakteristisches Aussehen. Schwache Enzymaktivitäten machen sich bemerkbar. In der 3. Phase (bis zur Geburt) wird die Funktionsaufnahme vorbereitet. Es bildet sich das typische Enzymmuster aus, das bei der Geburt bereits weitgehend dem erwachsener Tiere entspricht. Glykogen, das zunächst in großer Menge vorhanden ist, ist ab 57. ET nicht mehr nachweisbar. Ultrastrukturell ist vor allem die Entwicklung des Golgi-Apparates und eine erhöhte Sekretbildung auffällig. — Zwischen dem 59. Embryonaltag und 6. Lebenstag treten im Gallenblasenepithel zahlreiche mucoide Zellen in verschiedenen Funktionsstadien auf, die später nur noch selten in der Tiefe von Buchten vorkommen. — Nach der Geburt erfolgt ein verstärktes Höhenwachstum der Epithelzellen und der Abschluß der Enzymentwicklung. Etwa am 10. Lebenstag entspricht das Gallenblasenepithel dem ausgewachsener Tiere.
    Notes: Summary The development of the guinea pig gallbladder epithelium follows a distinct time schedule. During the first phase (up to 30th day of intrauterine life) the epithelial cells increase in number. They remain small and undifferentiated. In the second phase, from the 30th to the 44th day, cytodifferentiation is a dominating feature. The epithelial cells increase in height, the nuclei become more basal, the cells acquire their final zonal structure and the cell organelles exhibit their characteristic appearance. Weak enzyme activities can be observed. In the third phase, from the 45th day until birth, there is functional differentiation and the adult pattern of enzyme distribution is established. Glycogen appears first on day 29, increases in amount and then disappears by day 57. There is a marked development of the Golgi apparatus associated with increased synthesis of secretory material. — Between the 59th embryonic day and the 6th day of life mucoid cells with different functional states appear in the gallbladder epithelium. Later on these cells can be visualized only in the depths of the invaginations. After birth the epithelial cells become more columnar and by 10 days after birth the adult appearance of the epithelium is fully established.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Histochemistry and cell biology 45 (1975), S. 177-190 
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Es wird die Entwicklung des Gallenblaseneptithels des Meerschweinchens vom 19. Embyonaltag (ET) bis zum 31. Lebenstag (LT) färberisch-lichtmikroskopisch und histochemisch untersucht. Das zunächst mehrreihige Zylinderepithel wird bis zum 31. ET einschichtig. In der Folgezeit werden die Epithelzellen hochprismatisch und die Kerne wandern nach basal. Außerdem entstehen Epithelbuchten. Das Gallenblasenepithel enthält zunächst viel Glykogen, das bis zum 57. ET wieder verschwindet. Ab 30. ET können im Gallenblasenepithel neutrale und carboxylierte Mucosubstanzen nachgewiesen werden. Ab 48. ET treten in der Tiefe der Buchten und ab 51. ET in allen Gallenblasenepthelzellen sulfatierte Mucosubstanzen auf. Ab 58. ET kommen im Gallenblasenepithel „aufgehellte” mucoide Zellen vor, die nach dem 6. LT nur noch in den Buchten zu finden sind. Abgeschlossen ist die Entwicklung des Gallenblasenepithels etwa am 10. LT. — Bei den epithelialen Mucosubstanzen im Gallenblasenepithel des erwachsenen Meerschweinchens handelt es sich um GC-Muzine und S-Muzine A, 1,0 MgCl2.
    Notes: Summary The development of the guinea pig gallbladder epithelium was studied from the 19th day of intrauterine life to the 31st postnatal day by means of histological and histochemical staining reactions. At first, the epithelium is a columnar pseudostratified one. Its transformation into a simple columnar eptihelium is terminated by the 31st day of the intrauterine life. Then the epithelial cells become more columnar and their nuclei acquire a basal position. Somewhat later the epithelium invaginates the underlying mesenchyme. Up to the 57th day the epithelium contains much glycogen. Neutral and carboxylated muscosubstances are demonstrable after the 30th day. From the 48th day onwards sulphated mucosubstances can be visualized in some cells in the depth of the invaginations and from the 51st day in the epithelial cells of the gallbladder. “Light” mucoid cells appear first in the epithelium of day 58. After the 6th postnatal day the “light” cells are rarely seen in the invaginations. The development of the gallbladder epithelium is completed about the 10th postnatal day.—The epithelial mucosubstances of the gallbladder of the adult animal could be classified as GC mucins and S-mucinsA, 1.0 MgCl2.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Histochemistry and cell biology 51 (1977), S. 133-140 
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The mouse gallbladder epithelium was studied with light microscopic autoradiography and quantitative electron microscopy during fasting, refeeding and experimental gallstone formation. To determine the intracellular pathway of glycoproteins, H3-galactose was injected at different time intervals into the mice. At 10, 25 and 40 min after an intraperitoneal injection the gallbladders were fixed and prepared for light microscopy. As early as 10 min after injection, label was observed in supranuclear cytoplasmic regions and at 25 min, an increased radioactivity was present throughout the apical cytoplasm. At 40 min, silver grains were mainly present at the cell surface. Autoradiographs processed 25 min after an intraperitoneal H3-galactose injection after fasting for 48 h showed decreased supranuclear and apical radioactivity. After refeeding (12 h) there was an enhanced activity in both these regions. Animals fed a lithogenic diet for one month showed a marked increase of radioactive label mainly in cells of crypts and invaginations of the mouse gallbladder mucosa. Morphometric measurements of the Golgi apparatus revealed that deprivation of food significantly diminished the volume density of the Golgi apparatus. Refeeding the animals restored the volume density values to normal levels. In the course of gallstone formation there was a further significant increase in the volume density of the Golgi complexes as compared to controls.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 1432-0878
    Keywords: Cholecystokinin-pancreozymin (CCK-PZ) ; Glycoprotein secretion ; Mouse gallbladder ; Exo-endocytosis ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Structural changes in the gallbladder epithelial cells of the mouse were studied following in vivo and in vitro stimulation of the gallbladder with the gastrointestinal hormone cholecystokinin-pancreozymin (CCK-PZ). Signs of increased secretory activity were observed within the first 2–3 min after hormone administration. At the ultrastructural level, best visualized with the PA-CrA-silver technique, granule discharge was observed, as was an overall increase in size of the granules. After prolonged in vitro incubation or repeated in vivo stimulation, there was an almost total depletion of secretory granules. This phenomenon is accompanied by an enhanced uptake of extracellular thorium dioxide by endocytotic vesicles at the apical cell surface. An exocytosisendocytosis coupling mechanism may be important for membrane conservation in the gallbladder epithelial cells. The findings establish that the hormone CCK-PZ stimulates the secretion of glycoproteins from the mouse gallbladder epithelium.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 10
    Publication Date: 1976-09-01
    Print ISSN: 0302-766X
    Electronic ISSN: 1432-0878
    Topics: Biology , Medicine
    Published by Springer
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...