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  • 1985-1989  (31)
  • 1975-1979  (34)
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  • 1
    Electronic Resource
    Electronic Resource
    Isolation of α-tubulin genes from the human malaria parasite, Plasmodium falciparum: sequence analysis of α-tubulin (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 3 (1989), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: As a step towards indentifying exploitable differences between host and parasite at the molecular level, we have isolated and sequenced genomic clones encompassing an entire α-tubulin gene (designated α-tubulin I) from the human malaria parasite, Plasmodium falciparum. The gene, which contains two introns, encodes a product with a predicted length of 453 amino acid residues (50.3 kD). The protein sequence shows a high degree of homology to other α-tubulins, particularly that of the coccidian parasite, Toxoplasma gondii (94%), whose gene carries introns in identical positions. Only one copy of the α-tubulin I gene itself was found, although a second gene designated α-II was also identified which is closely related but which differs at both the nucleotide and amino acid sequence levels. The α-I and β-tubulin genes were found to reside on different chromosomes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1989.tb00136.x
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  • 2
    Electronic Resource
    Electronic Resource
    Cloning of a β-tubulin gene from Plasmodium falciparum (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 3 (1989), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: We describe the isolation and characterization of a gene for β-tubulin from the malaria parasite, Plasmodium falciparum. This organism appears to contain a single gene encoding β-tubulin. A single transcript from this gene can be detected in the total RNA of the parasite's asexual blood stages. The complete sequence for the gene has been elucidated. It has two introns, one of which has a position identical to that of a related parasite, Toxoplasma gondii. The gene shows the usual preference for codons with A or T in the third position. The predicted amino acid sequence is compared with that of T. gondii and the human host. Further comparisons between these and fungal sequences of β-tubulins resistant to benomyl, a drug binding this protein, highlight differences that could be exploited in the development of parasite-specific anti-tubulin drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1989.tb00137.x
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  • 3
    Electronic Resource
    Electronic Resource
    Identification of a single promoter in E. coli for rplJ , rplL and rpoBC (1978)
    [s.l.] : Nature Publishing Group
    Nature 276 (1978), S. 33-37 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A set of restriction fragments cloned into phage λ vectors has allowed us to locate a site necessary for full rpoBC expression. We find that these genes for the two large subunits of RNA polymerase and the genes, rplL and rplJ, for two ribosomal proteins, form a single ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/276033a0
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  • 4
    Electronic Resource
    Electronic Resource
    A mutation affecting the σ subunit of RNA polymerase changes transcriptional specificity (1978)
    [s.l.] : Nature Publishing Group
    Nature 273 (1978), S. 354-358 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The RNA polymerase mutation, alt-1, affects the σ subunit and alters the in vitro selectivity of RNA polymerase to parallel the in vivo phenotype. We propose that the mutation changes the distribution of functionally distinct polymerase ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/273354a0
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  • 5
    Electronic Resource
    Electronic Resource
    Expression of the genetic apparatus (1977)
    [s.l.] : Nature Publishing Group
    Nature 270 (1977), S. 121-122 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Gene Expression. Vol. 3: Plasmids and Phages. By Benjamin Lewin. Pp.942/ 928. (Wiley: London and New York, 1977.) Hardback £24; $40.65; paperback £10.25; $19.50. READERS of this journal will be familiar with the changing fortunes of microbial genetics in recent years. In ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/270121a0
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  • 6
    Electronic Resource
    Electronic Resource
    Systematic nomenclature for the RNA polymerase genes of prokaryotes (1976)
    [s.l.] : Nature Publishing Group
    Nature 260 (1976), S. 646-648 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] (1) The symbol rpo should be applied to the structural genes coding for RNA polymerase subunits, and to their regulatory genes and sites. (The symbol rna, proposed in 1968 (ref. 7), has not come into general use11.) (2) The genes for the a, b and b? subunits should be called rpoA, rpoB and rpoC, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/260646a0
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  • 7
    Electronic Resource
    Electronic Resource
    The capacity for joint visual attention in the infant (1975)
    [s.l.] : Nature Publishing Group
    Nature 253 (1975), S. 265-266 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Mothers who had volunteered as subjects in response to newspaper advertisements were asked to bring their infants into our laboratory at a time when the infant was 'usually active'. Thirty-four infants, 2-14 months old, were tested in a small, sparsely-furnished room (15 ft by 10 ft) with a one-way ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/253265a0
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  • 8
    Electronic Resource
    Electronic Resource
    Electrolytic manganese metal from chloride electrolytes. II. Effect of additives (1976)
    Springer
    Journal of applied electrochemistry 6 (1976), S. 453-462 
    Details
    ISSN: 1572-8838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract Results of beaker scale and large laboratory scale experiments on the deposition of manganese from chloride electrolytes using selenium based additives are reported. High cathode efficiencies (85–90%) were obtained at moderate selenium levels (0.03–0.06 gl−1). Selenium pick-up in the deposit was lower when selenium was added as the selenate [Se(VI)]. A cost/benefit analysis of selenium additions is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00616545
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  • 9
    Electronic Resource
    Electronic Resource
    Electrolytic manganese metal from chloride electrolytes. I. Study of deposition conditions (1976)
    Springer
    Journal of applied electrochemistry 6 (1976), S. 199-209 
    Details
    ISSN: 1572-8838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract Results of beaker scale and large laboratory scale experiments on the deposition of manganese from chloride electrolytes are reported for conditions where chlorine is the secondary anode product. Manganese concentration in the catholyte was found to be the most significant variable, with higher manganese levels (to 33 g Mn l−1) resulting in higher current efficiency (65–70%) and lower power consumption (5.5 kWh kg−1). Temperature (30–60°C) and current density (1.0–2.0 kAm−2) had opposing effects on current efficiency and power consumption. In the ranges studied, lower temperatures and higher current densities gave rise to increases in current efficiency and power consumption. The literature on the electrowinning of manganese from chloride electrolytes is reviewed and the anomalies in previous reports discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00616142
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  • 10
    Electronic Resource
    Electronic Resource
    Calcium-related disorders in plants — a possible explanation for the effect of weather (1978)
    Springer
    Plant and soil 50 (1978), S. 723-725 
    Details
    ISSN: 1573-5036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Incidence in the field of crop disorders known to be due to localised calcium deficiency bears little relation to soil calcium status, and is more often associated with particular types of weather. We are suggesting that brief periods of soil partial anaerobiosis following wet weather, and other unfavourable soil physical conditions such as compaction, lead to a temporary reduction in the distal, undifferentiated region of roots from which the majority of the calcium taken up is transported to the shoot. This might lead to a transient calcium deficiency in rapidly growing shoot tissues, and thence to necrosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02107226
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