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  • 1
    Series available for loan
    Series available for loan
    Mineral resources of the Arc Dome Wilderness Recommendation Area, Nye County, Nevada (1991)
    Washington, DC : United States Gov. Print. Off.
    Associated volumes
    Details Availability
    Call number: SR 90.0001(1961)
    In: U.S. Geological Survey bulletin
    Type of Medium: Series available for loan
    Pages: VI, 21 S. + 1 pl.
    Series Statement: U.S. Geological Survey bulletin 1961
    Language: English
    Location: Lower compact magazine
    Branch Library: GFZ Library
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  • 2
    Electronic Resource
    Electronic Resource
    Disease resistance in farm animals (1991)
    Springer
    Cellular and molecular life sciences 47 (1991), S. 923-934 
    Details
    ISSN: 1420-9071
    Keywords: Disease resistance ; genetic variations ; Mx system ; breeding techniques ; transgenes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Genetic variations in disease resistance of farm animals can be observed at all levels of defence against infectious agents. In most cases susceptibility to infections has polygenic origins. In domestic animals only a few instances of a single genetic locus responsible for disease resistance are known. A well-examined example is the Mx1 gene product of certain mice strains conferring selective resistance to influenza virus infections. Attempts to improve disease resistance by gene transfer of different gene constructs into farm animals include the use of monoclonal antibody gene constructs, transgenes consisting of antisense RNA genes directed against viruses and Mx1 cDNA containing transgenes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01929883
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  • 3
    Electronic Resource
    Electronic Resource
    A machine vision system for enhancing the teleoperation of an industrial robot (1994)
    Springer
    Machine vision and applications 7 (1994), S. 187-198 
    Details
    ISSN: 1432-1769
    Keywords: Motion computation ; Tracking ; Self-localization ; Image processing ; Navigation ; Camera calibration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract This paper describes a real-time vision system that enhances the teleoperation of a servicing tool used in the heat exchangers of nuclear power plants. The vision system is used to track the position of the tool as it moves over a sheet of tube ends. A map-based strategy is adopted for the estimation of the position. The system incorporates a novel method for a foreshortening correction that is applied prior to map referencing. A hypothesize and verify scheme locates two image features that correspond to two map features. An efficient scheme for extracting image features is developed to locate these two features (tube-end centers) in the image. Two different types of heat-exchanger tube sheets are accounted for. They are those with tube ends placed in a square grid and those with tube ends placed in a triangular grid. The map-based strategy minimizes the cumulative errors in the estimate of the tool head position. The resulting low-cost system has been tested on synthetic and real data. Performance results are given.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01211663
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  • 4
    Electronic Resource
    Electronic Resource
    Developmental and tissue-specific expression of the Q5 k gene (1991)
    Springer
    Immunogenetics 34 (1991), S. 28-38 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Expression of the Q5 k gene was examined by northern blot analysis and polymerase chain reaction (PCR) in the AKR mouse and various cell lines, each of the H-2 k haplotype. Our results show that Q5 k mRNA is present during the whole postimplantational development of the AKR embryo/fetus (gestation day 6 to 15). In the juvenile mouse (week 2 to 4) transcription of the Q5 k gene persisted in all organs examined. In contrast, in the adult animal expression of the Q5 k gene was limited to the thymus and uterus of the pregnant mouse. Upon malignant transformation, the amount of Q5 k -specific mRNA increased dramatically in thymus and could also be observed in the spleen of thymoma bearing animals. Expression of the Q5 k gene was also detectable in several transformed mouse cell lines. Mitogen stimulation or treatment with cytokines induced Q5 k expression in primary spleen cell cultures. A possible explanation for the tissue-restricted expression in the adult AKR mouse is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00212309
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  • 5
    Electronic Resource
    Electronic Resource
    Inhibition of Tumor Angiogenesis (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 732 (1994), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1994.tb24741.x
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  • 6
    Electronic Resource
    Electronic Resource
    Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth (1990)
    [s.l.] : Nature Publishing Group
    Nature 348 (1990), S. 555-557 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] During routine culturing of capillary endothelial cells we found a fungal contamination that produced a local gradient of endothelial cell rounding (Fig. 1). Cells that were only a few cell diameters away were normally spread, suggesting that the fungus was specifically inducing cell rounding ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/348555a0
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  • 7
    Electronic Resource
    Electronic Resource
    Disruption of the CNTF gene results in motor neuron degeneration (1993)
    [s.l.] : Nature Publishing Group
    Nature 365 (1993), S. 27-32 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] CNTF is a cytosolic molecule expressed postnatally in myelinating Schwann cells and in a sub-population of astrocytes. Although CNTF administration prevents lesion-mediated and genetically determined motor neuron degeneration, its physiological function remained elusive. Here it is ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/365027a0
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  • 8
    Electronic Resource
    Electronic Resource
    Sensitive detection of human growth hormone mRNA in routinely formalin-fixed, paraffin-embedded transgenic mouse tissues by non-isotopic in situ hybridization (1994)
    Springer
    Histochemistry and cell biology 102 (1994), S. 145-152 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A sensitive technique of non-isotopic in situ hybridization (NISH) is presented, which permits the detection of human growth hormone (hGH) mRNA in routinely formalin-fixed, paraffin-embedded transgenic mouse tissues and human post mortem pituitaries; the latter were used as positive tissue controls in this study. In addition, a double staining procedure combining NISH and immunohistochemistry for the visualization of both hGH and hGH mRNA in the same paraffin section is described. Digoxigenin-labelled antisense hGH RNA was used for NISH of hGH mRNA. The NISH protocol was based upon an established radioactive method. Alkaline phosphatase and horseradish peroxidase-based immunoenzymatic procedures for the detection of digoxigenin-labelled RNA probes using different chromogens [4-nitro blue tetrazolium chloride (NBT), Fast Blue BB, New Fuchsin, and 3,3′-diaminobenzidine tetrahydrochloride (DAB) with or without intensification of the DAB staining] were compared. The proteolytic tissue pretreatment and the detection procedure were found to be the most critical steps for successful visualization of hGH mRNA. After optimization of the permeabilization conditions, hGH mRNA could be visualized in each case studied when alkaline phosphatase/NBT-based detection was employed. The NISH technique presented here, performed either separately or in combination with immunohistochemistry, permits retrospective analyses, of hGH (trans)gene expression in archival, paraffin-embedded specimens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00269018
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  • 9
    Electronic Resource
    Electronic Resource
    Efficient generation of chimaeric mice using embryonic stem cells after long-term culture in the presence of ciliary neurotrophic factor (1994)
    Springer
    Transgenic research 3 (1994), S. 152-158 
    Details
    ISSN: 1573-9368
    Keywords: CNTF ; LIF ; ES cells ; differentiation ; proliferation ; chimaera
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The aim of our study was to evaluate whether ciliary neurotrophic factor (CNTF) can substitute for leukaemia inhibitory factor (LIF) in maintaining pluripotential embryonic stem (ES) cells in culture. Two subclones of D3 ES cells were used to assess cell proliferation and differentiation in the presence of CNTF, LIF or Buffalo rat liver (BRL) cell-conditioned medium, or in the absence of exogenous differentiation inhibiting factors. ES cells maintained in medium supplemented with CNTF for up to four weeks were injected into blastocysts to investigate theirin vivo pluripotency in terms of chimaera formation. CNTF inhibited ES cell differentiation in a dose-dependent manner. The most effective concentration was 10 ng CNTF per ml of medium. The effects of CNTF on ES cell differentiation and proliferation were comparable to those of LIF at the same concentration. BRL cell-conditioned medium was less effective at preventing ES cell differentiation but induced their proliferation very markedly. Both ES cell clones efficiently formed chimaeras after long-term culture with CNTF as the only differentiation inhibiting agent. The ability of these ES cells to colonize the germ-line is the ultimate proof that CNTF can preserve the pluripotency of ES cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01973982
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  • 10
    Electronic Resource
    Electronic Resource
    Controlled release of 4-hydroperoxycyclophosphamide from the fatty acid dimer-sebacic acid copolymer (1992)
    New York, NY : Wiley-Blackwell
    Polymers for Advanced Technologies 3 (1992), S. 311-316 
    Details
    ISSN: 1042-7147
    Keywords: Controlled release ; Polymeric release ; Drug delivery ; Malignant glioma ; Cyclophosphamide ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Controlled polymeric release of chemotherapeutic agents has shown promise in the management of malignant gliomas. 4-Hydroperoxycyclophosphamide (4HC), loaded on the fatty acid dimer-sebacic acid copolymer (FAD:SA, 1:1), significantly prolonged survival in rats implanted with F98 and 9L gliomas. Here, we studied the in vitro and in vivo release kinetics in phosphate-buffered saline and rat brain of 20% 4HC/FAD:SA (wt:wt), the optimal dose for treatment of rat gliomas. In vitro release under infinite sink conditions was steady over the initial 12 hr to a peak of 20-35% of impregnated drug, consistent with early phase control via surface erosion. Release over the next 3 weeks was minimal, consistent with barrier formation around the polymer by an oily fatty acid dimer degradation product and consequent slowing of release. However, the polymer started to disintegrate by day 4, and there were minimal visible remnants by 3 weeks. Thus, a considerable amount of polymer-carried drug was probably lost in the disintegrating fragments. Also, drug loss is expected from its inherent hydrolytic instability. In vivo release into brain revealed two peak levels of drug at 0-1 hr and 5-20 days. With loaded polymer implanted intraperitoneally or cyclophosphamide injected systemically, peak brain drug levels were measured in 2-8 hr, with substantial decrease by 48 hr without a second peak. Brain levels were substantially higher than blood levels at all time periods. We conclude that FAD:SA (1:1) adequately protects the otherwise labile 4HC, allowing effective and substained drug release in vivo. Furthermore, it should be possible to modify the polymer to adjust the time of peak release for more beneficial therapeutic effects.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pat.1992.220030605
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