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  • Springer  (69)
  • 1990-1994  (63)
  • 1965-1969  (6)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 44 (1993), S. 301-302 
    ISSN: 1432-1041
    Keywords: Adriamycin ; Haemodialysis ; adriamycinol ; pharmacokinetics ; moment analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 44 (1993), S. 79-84 
    ISSN: 1432-1041
    Keywords: Methylphenidate enantiomers ; Narcoleptic patient ; oral administration ; healthy volunteers ; plasma concentration ; nonlinear kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have studied the pharmacokinetics of methylphenidate enantiomers after the oral administration of different doses of racemic methylphenidate to one patient with narcolepsy and to four healthy volunteers. The plasma concentrations of (+)-methylphenidate were much higher than those of (−)-methylphenidate after each dose in all subjects. In the patient the oral clearance (CL/f) of (+)-methylphenidate fell 3-fold and the area under the concentration-time curve (AUC) rose 7-fold when the dose was increased from 20 to 40 mg (from 0.27 to 0.53 mg·kg−1), in spite of the relatively constant terminal half-life of 2.6–2.7 h. Similar dose-dependency was also observed in the healthy volunteers in the dose range of 10–60 mg (0.12–0.77 mg·kg−1). The mean value of CL/f for the 40 mg dose was significantly lower than that for the 20 mg dose. The mean AUC of the (+)-isomer corrected to a dose of 10 mg increased significantly between the 20 mg and 40 mg doses. In the urine (+)- and (−)-ritalinic acid were excreted for 48 h after each dose as 32–37% and 34–40% of the dose respectively. The mean total recoveries (sum of enantiomers of methylphenidate and its metabolite, ritalinic acid) in the urine were relatively constant (63–78% of the doses), suggesting that the changes in AUC with dose may not be due to a change in the intestinal absorption of racemic methylphenidate. We conclude that the nonlinear kinetics of (+)-methylphenidate may be due to saturation of its presystemic elimination.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Oxidation of metals 38 (1992), S. 347-363 
    ISSN: 1573-4889
    Keywords: SUS430 stainless steel ; abnormal oxidation ; moist atmosphere ; incubation period
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The oxidation behavior of SUS430 stainless steel was studied in moist atmospheres $$(P_{H_2 O} = 3.4 \times 10^3 Pa, P_{O_2 } = 20 \sim 12.6 \times 10^3 Pa)$$ at 873 K. The mass gain during oxidation was measured by using a thermobalance. An abnormal rapid oxidation occurred after an incubation period which increased with increasing oxygen partial pressure. The product on the surface was identified as α-Fe2O3 of whisker-like morphology by X-ray diffraction and scanning electron microscopy. The abnormal oxidation was not observed under high-oxygen partial pressures. The results of the experiments conducted in various atmospheres were analyzed and are discussed.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of materials science 1 (1990), S. 114-117 
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Composition control of hydroxyapatite by post-treatment in an alkaline solution was examined. Non-stoichiometric material having a Ca/P ratio of 1.60 was treated in distilled water (pH 6.5) and in a concentrated aqueous solution of ammonia (pH 11). The Ca/P ratio of the material increased with the latter treatment and the stoichiometric composition (Ca/P=1.67) was achieved after six treatments. In contrast, essentially no change in composition was found with the former treatment. The treated powder had high thermal stability of nominally a stoichiometric composition. Composition change by incongruent dissolution is discussed.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Origins of life and evolution of the biospheres 23 (1993), S. 177-183 
    ISSN: 1573-0875
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences
    Notes: Abstract Thermal heterocomplex molecules made by heating amino acids, aspartic acid and proline, exhibit an autocatalytic accretion in their aqueous suspension under appropriate conditions of their temperature and concentration.
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  • 6
    ISSN: 1436-2449
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary The effect of several forms of suspension polymerized poly(vinyl chloride) particles on mechanochemical block copolymerization in the solid poly(vinyl chloride)-styrene-sodium dodecyl sulfate solutions has been studied by ultrasonic irradiation at 60 °C. The block copolymerization of styrene was initiated by free radicals produced from the poly(vinyl chloride) particles by ultrasonic waves. The rates of copolymerization increased with increasing the additional amount of the solid poly(vinyl chloride), the porosity, and the average diameter of the grain particles. In particular, the influence of the average diameter was much larger than that of the porosity. When the porosity and the average diameter were increased, the rates of decrease in the viscosity-average degree of polymerization of the degraded poly(vinyl chloride) were much increased. In addition, the changes in the composition of the block copolymer and homopolymers in the reaction products were obtained.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of radioanalytical and nuclear chemistry 140 (1990), S. 365-377 
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Determination of the lanthanoids in a neutral hot spring water has been studied by menas of neutron activation analysis. The aluminium coprecipitation process, which used aluminium as the collector of the lanthanoids, was incorporated in the preparation of a sample for irradiation. Nine lanthanoids, La, Ce, Nd, Sm, Eu, Tb, Tm, Yb and Lu, were determined at ppt levels with satisfactory precision, indicating the effectiveness of aluminium coprecipitation.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract We present a brief description of the status of our accelerator mass spectrometry system at the tandem accelerator facility of the University of Tokyo and some examples of measurements in environmental samples which have been recently performed. Fallout10Be activities have been measured, from rain samples collected monthly in Tokyo from 1975 to 1977 and from 1984 to 1986, and compared with those of7Be and137Cs. A preliminary experiment on14C measurement in volcanic gas samples is also reported.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Journal of radioanalytical and nuclear chemistry 139 (1990), S. 65-77 
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Determination of Th and U in acidic hot spring and crater lake waters was investigated by neutron activation analysis (NAA). Before neutron irradiation, Th and U were preconcentrated and separated from interfering nuclides such as alkali metals and halogens by coprecipitation with aluminium. Irradiation was carried out in two ways, viz., irradiation with Cd foil wrapping (epithermal NAA) and irradiation without Cd foil wrapping (normal NAA). The final determined values of Th and U were at ppb levels. Higher reliability of the determined values was obtained for Th than for U. It was found that epithermal NAA was more effective for the determination of these two actinides than normal NAA and was more effective for the determination of U than that of Th.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 25 (1969), S. 551-553 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Die rhythmischen Potentiale an der aufsteigenden Phase derb-Welle des von der In-vitro-Präparation der Warmblüternetzhaut abgeleiteten Elektroretinogramms wurden in vivo dargestellt.
    Type of Medium: Electronic Resource
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