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  • 1990-1994  (273)
  • 1985-1989  (239)
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  • 1
    Call number: AWI A13-95-0173-1 ; AWI A13-95-0173-4 ; AWI A13-95-0173-3 ; AWI A13-95-0173-2
    Type of Medium: Monograph available for loan
    Pages: VII, 586 S.
    ISBN: 8122403840
    Branch Library: AWI Library
    Branch Library: AWI Library
    Branch Library: AWI Library
    Branch Library: AWI Library
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of natural products 54 (1991), S. 755-758 
    ISSN: 1520-6025
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Chemical reviews 93 (1993), S. 1945-1990 
    ISSN: 1520-6890
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of natural products 49 (1986), S. 941-941 
    ISSN: 1520-6025
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Pure and applied geophysics 133 (1990), S. 447-474 
    ISSN: 1420-9136
    Keywords: Source spectra ; RMS acceleration ; Mexican earthquakes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Strong motion (SM) data of six Mexican subduction zone earthquakes (6.4≤M S≤8.1) recorded near the epicentral zone are analyzed to estimate their far-field source acceleration spectra at higher frequencies (f≥0.3 Hz). Apart from the usual corrections such as geometrical spreading (1/R), average radiation pattern (0.6), free surface amplification (a factor of 2), and equal partitioning of the energy into two orthogonal horizontal components (a factor of 1/ $$\sqrt 2 $$ ), the observed spectra are corrected for a frequency dependentQ(Q=100f), a site dependent filter (e −πkf ), and amplification ofS waves near the surface (a factor of about 2 atf≥2Hz). We takeR as the average distance from the rupture area to the site. If we model the high frequency plateau (f≥1 Hz) of the source spectra, by a point source ω−2-model, and interpret them in terms of Brune's model we obtain δσ between 50 and 100 bars for all earthquakes. The low-frequency broadband teleseismicP wave spectra, corrected witht *=1.0 s, agrees within a factor of two with SM source spectra near 1 Hz. The ω−2-model is inadequate to explain the observed source spectra in a broad frequency range; these resemble spectra given byGusev (1983) with some differences. SM source acceleration spectra require significant corrections to explain observed spectra and RMS acceleration (arms) (a) at farther coastal sites for extended sources due to directivity effect and (b) at inland sites (100≤R≤200 km) because of unaccounted path and site amplification and/or invalidity of body-wave approximation. The observed spectra and arms at these sites are significantly greater than the predicted values from the estimated source spectra.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Pure and applied geophysics 123 (1985), S. 624-637 
    ISSN: 1420-9136
    Keywords: Monsoon rainfall ; Extended EOF analysis ; 40-day oscillation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The low frequency spatio-temporal intraseasonal evolution of monsoon rainfall over India is studied by considering the pentad rainfall averages taken over 2.5° wide and 5.0° long blocks lying across the central longitudinal and latitudinal transacts. The time-latitude cross sections show south to north progressions of rainfall anomalies with a recurrence period of about 40 days. The progressions show considerable inter-annual and intra-seasonal variation in frequency, amplitude and rate of progression. The extended empirical orthogonal function analysis shows that the first two most important functions correspond to this northward progression of rain anomalies recurring after an interval of about 40 days. The rate of progression of anomalies is about 0.5° Lat./day. The time-longitude cross sections show the movement of rainfall anomalies towards both directions east and the west, with slight preference towards the east. The importance of these signals in rainfall forecasting is foreseen.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 44 (1988), S. 782-785 
    ISSN: 1420-9071
    Keywords: Methyl nitrosourea (MNU) ; sister chromatid exchange (SCE) ; aging ; mutagenic sensitivity ; background genotype
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We studied mice from five strains (BALB/c, C3H/HeSnJ, C57BL/6J, Csb and 129/ReJ) at two ages (young, 10±1 weeks; and old, 67±3 weeks) for the induction of sister chromatid exchanges (SCEs) in vivo by methyl nitrosourea (MNU). The SCE frequency is genotype-specific. The F1 phenotype resembles the ‘low’ responding parent. SCE induction is significantly lower in the older animals of each strain than their younger counterparts, and the reduction of SCE/cell with old age is strain-specific. A general explanation for these results must include strain differences in relative mutagenic sensitivity, genotype-specific pattern of reduction in DNA repair and other such factors affecting SCE formation, with old age.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Human genetics 〈Berlin〉 90 (1993), S. 635-640 
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A sample of 114 primary breast tumors and corresponding constitutional DNA were tested for loss of heterozygosity (LOH) of the YNZ22 and p53 genes, both located in the 17p13 region. Loss of the p53 allele was found in 28 of 44 primary breast carcinomas (64%). In contrast LOH in only 26 of 61 tumors (43%) was detected with the variable number of tandem repeats (VNTR) probe YNZ22 mapping at 17p13.3 close to the p53 locus at 17p13.1. Among 19 tumors informative for both probes allele loss at 17p13.3 never occurred without p53 involvement. These data suggest, that p53 is the target of 17p13 allelic deletions in human breast cancer. Immunohistochemistry showed overexpression of the p53 protein in 25 of 50 cases (50%) presumably reflecting activating point mutations. Overexpression was not correlated with allele loss but seemed to be closely related to the presence of point mutations in this study. No homozygous deletions or rearrangements of the p53 gene were detected. This would argue for an important role of heterozygous p53 mutations in human breast cancer.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Permanent lymphoblastoid cell lines are important in the molecular analysis and characterization of human genetic disorders, when immortalized cells must be banked for future diagnostic or research purposes. However, routine methods for transformation using Epstein-Barr virus (EBV) require blood volumes that may be difficult to collect from clinically compromised neonates and small children. Here we report a modified transformation procedure utilizing blood samples of small volume (less than 1.0ml), which we have found to be particularly useful for the immortalization of lymphocytes destined for future molecular genetic studies.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Cytogenetic and molecular genetic findings in 91 patients with Turner syndrome are reported. In 87 patients, chromosome studies were carried out both in lymphocyte and fibroblast cultures. Mosaicism was demonstrated in 58 of these patients (66.7%), whereas only 18 (20.7%) were apparent non-mosaic 45,X, and 11 patients (12.6%) showed non-mosaic structural aberrations of the X chromosome. Among the mosaic cases 16 (18.4% of all patients) displayed a second cell line containing small marker chromosomes. The association of Y-specific chromosomal material with the presence of marker chromosomes was demonstrated in 6 out of 7 mixoploid fibroblast cell lines by polymerase chain reaction amplification and by Southern-blot analysis. The observation of ring formation and morphological variability in vivo and in vitro, and the continous reduction in the percentage of cells containing marker chromosomes in longterm cultivation experiments indicated an increased instability of marker chromosomes. The findings suggest that in vivo selection of structurally altered sex chromosomes exists. Thus, the observation of apparent non-mosaic 45,X chromosomal complements in liveborn individuals with Turner syndrome does not contradict the hypothesis that some degree of mosaicism is necessary for survival in early pregnancy.
    Type of Medium: Electronic Resource
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