ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Characterization of the adenine binding sites of two Dolichos biflorus lectins (1992)
    s.l. : American Chemical Society
    Biochemistry 31 (1992), S. 6938-6942 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00145a011
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Purification of thrombospondin from human platelets (1994)
    Springer
    Methods in cell science 16 (1994), S. 217-222 
    Details
    ISSN: 1573-0603
    Keywords: α-granules ; Heparin-affinity ; Platelets ; Thrombospondin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Thrombospondins are a rapidly growing family of adhesive proteins that have diverse activities to modulate cellular growth, motility, and gene expression. Thrombospondin-1 (TSP) was the first identified member of this family and is the major form of thrombospondin in human platelets. A method is described to prepare TSP from human platelets in biologically active form with minimal degradation or contamination with other platelet proteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01540654
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Specific simple sugars promote chemotaxis and chemokinesis of corneal endothelial cells (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 157 (1993), S. 359-366 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Bovine corneal endothelial cells showed a strong migratory response to specific simple sugars (D-glucose and sucrose, but not L-glucose, sorbitol, lactose, or D-galactose) at concentrations above 10 mM. Checkerboard analysis of the migratory responses in modified Boyden chambers indicated both chemotactic and chemokinetic effects. Serum starvation of the cultures increased the chemotaxis towards D-glucose and 2-deoxy-D-glucose, but not towards sucrose. Migration to sucrose and glucose was inhibited by chelation of extracellular calcium or by inhibition of Na+,K+ ATPase with ouabain. To date, this migratory response has been found only in corneal endothelial cells. Neither human melanoma cells, human breast carcinoma cells, bovine aortic endothelial cells, nor bovine microvascular endothelial cells migrated towards simple sugars, although all cell types migrated toward fibronectin in chemotaxis assays. After 16-19 passages in culture, bovine corneal endothelial cells retained their ability to migrate towards fibronectin, but lost their ability to migrate towards sugars. This loss of migratory response was accompanied by a sevenfold decrease in Na+,K+ ATPase activity. Although loss of Na+,K+ ATPase activity accompanied the loss of migratory response, pretreatment of cell cultures with 25 mM glucose did not stimulate, but rather lowered Na+,K+ ATPase activity in low or high passage cultures. © 1993 Wiley-Liss, Inc.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041570220
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Apolipoprotein E: A potent inhibitor of endothelial and tumor cell proliferation (1994)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 54 (1994), S. 299-308 
    Details
    ISSN: 0730-2312
    Keywords: DNA ; heparin-binding growth factors ; basic fibroblast growth factor ; carcinoma cells ; angiogenesis ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Recombinant human apolipoprotein E3 (apoE), purified from E. coli, inhibited the proliferation of several cell types, including endothelial cells and tumor cells in a dose- and time-dependent manner. ApoE inhibited both de novo DNA synthesis and proliferation as assessed by an increase in cell number. Maximal inhibition of cell growth by apoE was achieved under conditions where proliferation was dependent on heparin-binding growth factors. Thus, at low serum concentrations (0-2.5%) basic fibroblast growth factor (bFGF) stimulated the proliferation of bovine aortic endothelial (BAE) cells severalfold. The bFGF-dependent proliferation was dramatically inhibited by apoE with an IC50 ≈ 50 nM. Under conditions where cell proliferation was mainly serum-dependent, apoE also suppressed growth but required higher concentrations to be effective (IC50 ≈ 500 nM). ApoE also inhibited growth of bovine corneal endothelial cells, human melanoma cells, and human breast carcinoma cells. The IC50 values obtained with these cells were generally 3-5 times higher than with BAE cells. Inhibition of cell proliferation by apoE was reversible and dependent on the time of apoE addition to the culture. In addition, apoE inhibited the chemotactic response of endothelial cells that were induced to migrate by a gradient of soluble bFGF. Inhibition of cell proliferation by apoE may be mediated both by competition for growth factor binding to proteoglycans and by an antiadhesive activity of apoE. The present results demonstrate that apoE is a potent inhibitor of proliferation of several cell types and suggest that apoE may be effective in modulating angiogenesis, tumor cell growth, and metastasis.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240540306
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Modulation of endothelial cell proliferation, adhesion, and motility by recombinant heparin-binding domain and synthetic peptides from the type I repeats of thrombospondin (1993)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 53 (1993), S. 74-84 
    Details
    ISSN: 0730-2312
    Keywords: chemotaxis ; extracellular matrix ; angiogenesis ; basic fibroblast growth factor ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Thrombospondin is an inhibitor of angiogenesis that modulates endothelial cell adhesion, proliferation, and motility. Synthetic peptides from the second type I repeat of human thrombospondin containing the consensus sequence -Trp-Ser-Pro-Trp- and a recombinant heparin binding fragment from the amino-terminus of thrombospondin mimic several of the activities of the intact protein. The peptides and heparin-binding domain promote endothelial cell adhesion, inhibit endothelial cell chemotaxis to basic fibroblast growth factor (bFGF), and inhibit mitogenesis and proliferation of aortic and corneal endothelial cells. The peptides also inhibit heparin-dependent binding of bFGF to corneal endothelial cells. The antiproliferative activities of the peptides correlate with their ability to bind to heparin and to inhibit bFGF binding to heparin. Peptides containing amino acid substitutions that eliminate heparin-binding do not alter chemotaxis or proliferation of endothelial cells. Inhibition of proliferation by the peptide is time-dependet and reversible. Thus, the antiproliferative activities of the thrombospondin peptides and recombinant heparin-binding domain result at least in part from competition with heparin-dependent growth factors for binding to endothelial cell proteoglycans. These results suggest that both the Trp-Ser-Xaa-Trp sequences in the type I repeats and the amino-terminal domain play roles in the antiproliferative activity of thrombospondin.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240530109
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    facet.materialart.
    Unknown
    Reconstructing Late Quaternary retreat of the NE Greenland Ice Stream (2018)
    In:  EPIC3European Geosciences Union General Assembly 2018, Vienna, 2018-04-08-2018-04-13
    Details
    Publication Date: 2018-02-25
    Description: Today, the NE Greenland Ice Stream (NEGIS) drains ∼ 15% of the Greenland Ice Sheet (GrIs) and has a sea-level equivalent of 1.1-1.4 m. Stabilised downstream by two floating ice shelves, 79N and Zachariae Isstrom, until recently, it has shown little response to increased atmospheric and oceanic warming. However, since 2010 Zachariae Isstrom in particular has experienced an accelerated rate of grounding line retreat ( ∼ 4 km) and significant ice shelf loss. This suggests this sector of the GrIS is now responding to changes in oceanic and/or climatic conditions. To place these observations into context a better understanding of the response of NEGIS to past oceanic and temperature change beyond the instrumental record is necessary. The project ‘NEGIS’ led by Durham University, aims to reconstruct the history of the NEGIS from the Last Glacial Maximum (LGM) to present to better understand past ice stream response to a warming climate. This contribution presents results and interpretations from an offshore dataset collected on the RV Polarstern, cruise PS100, in 2016. Swath bathymetry, sub-bottom profile data and 41 sediment cores where collected from across the NE Greenland continental shelf, with data collection concentrated along the Norske Trough and the area directly in front of the 79N floating ice tongue. On the outer shelf streamlined subglacial bedforms, grounding-zone wedges and moraines as well as over-consolidated subglacial tills, record ice sheet advance to the shelf edge. A single radiocarbon date from a shelf edge core indicates that shelf edge deglaciation had begun by 17.9 ka cal BP. Ice shelf presence is captured in 25 cores from the outer shelf to the 79N floating ice tongue at the present day coast. Ice shelf recession is characterised by a switch from laminated sediments containing no ice rafted debris (IRD), to a massive mud containing gravel to pebble sized clasts. Preliminary foraminifera analysis indicates that the sub-ice shelf facies where poor in abundance and dominated by polar glacimarine species. However, before ice-shelf breakup an increase in foraminifera abundance occurs with a species assemblage dominated by the Cassidulina neoteritis, an Atlantic Water indicator, which continues to dominate the species assemblage in ice-shelf free conditions. This pattern implies that Atlantic Waters were present prior to ice shelf breakup and had a continued presence after ice shelf disappearance. This suggests that oceanic forcing likely played a significant role in the deglaciation of the NEGIS. Dating this transition in cores from across the NE Greenland continental shelf will provide the first constraint on both ice stream and ice shelf retreat since the LGM.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Conference , notRev
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 7
    facet.materialart.
    Unknown
    Therapeutic targeting of the thrombospondin-1 receptor CD47 to treat liver cancer (2015)
    Springer
    Details
    Publication Date: 2015-03-01
    Print ISSN: 1873-9601
    Electronic ISSN: 1873-961X
    Topics: Biology , Medicine
    Published by Springer
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 8
    facet.materialart.
    Unknown
    A function-blocking CD47 antibody modulates extracellular vesicle-mediated intercellular signaling between breast carcinoma cells and endothelial cells (2017)
    Springer
    Details
    Publication Date: 2017-11-29
    Print ISSN: 1873-9601
    Electronic ISSN: 1873-961X
    Topics: Biology , Medicine
    Published by Springer
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 9
    facet.materialart.
    Unknown
    Characterization of the adenine binding sites of two Dolichos biflorus lectins (1992)
    American Chemical Society
    Details
    Publication Date: 1992-08-04
    Print ISSN: 0006-2960
    Electronic ISSN: 1520-4995
    Topics: Biology , Chemistry and Pharmacology
    Published by American Chemical Society
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    facet.materialart.
    Unknown
    Metabolomic Analysis Reveals Unique Biochemical Signatures Associated with Protection from Radiation Induced Lung Injury by Lack of cd47 Receptor Gene Expression (2019)
    Molecular Diversity Preservation International
    Details
    Publication Date: 2019-10-08
    Description: The goal of this study was to interrogate biochemical profiles manifested in mouse lung tissue originating from wild type (WT) and cd47 null mice with the aim of revealing the in vivo role of CD47 in the metabolic response to ionizing radiation, especially changes related to the known association of CD47 deficiency with increased tissue viability and survival. For this objective, we performed global metabolomic analysis in mouse lung tissue collected from (C57Bl/6 background) WT and cd47 null mice with and without exposure to 7.6 Gy whole body radiation. Principal component analysis and hierarchical clustering revealed a consistent separation between genotypes following radiation exposure. Random forest analysis also revealed a unique biochemical signature in WT and cd47 null mice following treatment. Our data show that cd47 null irradiated lung tissue activates a unique set of metabolic pathways that facilitate the handling of reactive oxygen species, lipid metabolism, nucleotide metabolism and nutrient metabolites which may be regulated by microbial processing. Given that cd47 has pleiotropic effects on responses to ionizing radiation, we not only propose this receptor as a therapeutic target but postulate that the biomarkers regulated in this study associated with radioprotection are potential mitigators of radiation-associated pathologies, including the onset of pulmonary disease.
    Electronic ISSN: 2218-1989
    Topics: Biology , Medicine
    Published by Molecular Diversity Preservation International
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...