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  • 1995-1999  (678)
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Keywords
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Year
  • 1
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    Diachronous uplift of the Tibetan plateau starting 40 Myr ago (1998)
    In:  Nature, Taipei, Elsevier, vol. 394, no. 6695, pp. 769-773, pp. B02317, (ISBN: 0-12-018847-3)
    Details
    Publication Date: 1998
    Keywords: Crustal deformation (cf. Earthquake precursor: deformation or strain) ; Geol. aspects ; China ; Gravimetry, Gravitation ; Plate tectonics
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    BIBLIOGRAPHY SEISMOLOGY
  • 2
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    Computer simulation of single-layer buckling (1996)
    In:  Journal of Structural Geology, Taipei, 3-4, vol. 18, no. 1, pp. 643-655, pp. B05301, (ISSN: 1340-4202)
    Details
    Publication Date: 1996
    Keywords: Modelling ; Crustal deformation (cf. Earthquake precursor: deformation or strain) ; Elasticity ; Muehlhaus ; Muhlhaus ; Structural geology ; JSG
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    BIBLIOGRAPHY SEISMOLOGY
  • 3
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    Coaxial nanocable: silicon carbide and silicon oxide sheathed with boron nitride and carbon (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-08-14
    Description: Multielement nanotubes comprising multiple phases, with diameters of a few tens of nanometers and lengths up to 50 micrometers, were successfully synthesized by means of reactive laser ablation. The experimentally determined structure consists of a beta-phase silicon carbide core, an amorphous silicon oxide intermediate layer, and graphitic outer shells made of boron nitride and carbon layers separated in the radial direction. The structure resembles a coaxial nanocable with a semiconductor-insulator-metal (or semiconductor-insulator-semiconductor) geometry and suggests applications in nanoscale electronic devices that take advantage of this self-organization mechanism for multielement nanotube formation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhang -- Suenaga -- Colliex -- Iijima -- New York, N.Y. -- Science. 1998 Aug 14;281(5379):973-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Y. Zhang, Fundamental Research Laboratories, NEC Corporation, 34 Miyukigaoka, Tsukuba, Ibaraki 305-8501, Japan. K. Suenaga, Laboratoire de Physique des Solides, URA 002, Universite de Paris-Sud, Batiment 510, 91405 Orsay, France〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9703508" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 4
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    Neuronal protection in stroke by an sLex-glycosylated complement inhibitory protein (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-07-27
    Description: Glycoprotein adhesion receptors such as selectins contribute to tissue injury in stroke. Ischemic neurons strongly expressed C1q, which may target them for complement-mediated attack or C1qRp-mediated clearance. A hybrid molecule was used to simultaneously inhibit both complement activation and selectin-mediated adhesion. The extracellular domain of soluble complement receptor-1 (sCR1) was sialyl Lewis x glycosylated (sCR1sLex) to inhibit complement activation and endothelial-platelet-leukocyte interactions. sCR1 and sCR1sLex colocalized to ischemic cerebral microvessels and C1q-expressing neurons, inhibited neutrophil and platelet accumulation, and reduced cerebral infarct volumes. Additional benefit was conferred by sialyl Lewis x glycosylation of the unmodified parent sCR1 molecule.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huang, J -- Kim, L J -- Mealey, R -- Marsh, H C Jr -- Zhang, Y -- Tenner, A J -- Connolly, E S Jr -- Pinsky, D J -- R01 HL55397/HL/NHLBI NIH HHS/ -- R01 HL59488/HL/NHLBI NIH HHS/ -- R01 NS35144/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1999 Jul 23;285(5427):595-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10417391" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Platelets/physiology ; Cell Adhesion ; Cerebral Cortex/blood supply/immunology/metabolism ; Cerebral Infarction/drug therapy ; Cerebrovascular Circulation ; Cerebrovascular Disorders/*drug therapy/immunology/physiopathology ; Complement Activation ; Complement C1q/metabolism ; Glycosylation ; Humans ; Ischemic Attack, Transient/*drug therapy/immunology/physiopathology ; Leukocytes/physiology ; Mice ; Neurons/immunology/metabolism ; Neuroprotective Agents/administration & dosage/adverse ; effects/metabolism/*therapeutic use ; Neutrophils/physiology ; Oligosaccharides/administration & dosage/adverse effects/metabolism/*therapeutic ; use ; Platelet Adhesiveness ; Receptors, Complement/administration & dosage/metabolism/*therapeutic use ; Reperfusion Injury/drug therapy/immunology/metabolism ; Selectins/metabolism ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    PAPER CURRENT
  • 5
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    Discovery of a small molecule insulin mimetic with antidiabetic activity in mice (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-05-13
    Description: Insulin elicits a spectrum of biological responses by binding to its cell surface receptor. In a screen for small molecules that activate the human insulin receptor tyrosine kinase, a nonpeptidyl fungal metabolite (L-783,281) was identified that acted as an insulin mimetic in several biochemical and cellular assays. The compound was selective for insulin receptor versus insulin-like growth factor I (IGFI) receptor and other receptor tyrosine kinases. Oral administration of L-783,281 to two mouse models of diabetes resulted in significant lowering in blood glucose levels. These results demonstrate the feasibility of discovering novel insulin receptor activators that may lead to new therapies for diabetes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhang, B -- Salituro, G -- Szalkowski, D -- Li, Z -- Zhang, Y -- Royo, I -- Vilella, D -- Diez, M T -- Pelaez, F -- Ruby, C -- Kendall, R L -- Mao, X -- Griffin, P -- Calaycay, J -- Zierath, J R -- Heck, J V -- Smith, R G -- Moller, D E -- New York, N.Y. -- Science. 1999 May 7;284(5416):974-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Endocrinology, Merck Research Laboratories, R80W250, Post Office Box 2000, Rahway, NJ 07065, USA. bei_zhang@merck.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10320380" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Animals ; Ascomycota/*metabolism ; Binding Sites ; Blood Glucose/metabolism ; CHO Cells ; Cricetinae ; Diabetes Mellitus, Type 2/*drug therapy ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Enzyme Activation ; Glucose Tolerance Test ; Hyperglycemia/drug therapy ; Hypoglycemic Agents/chemistry/metabolism/*pharmacology/therapeutic use ; Indoles/chemistry/metabolism/*pharmacology/therapeutic use ; Insulin/blood/metabolism/*pharmacology ; Insulin Receptor Substrate Proteins ; Mice ; Mice, Mutant Strains ; Mice, Obese ; Molecular Mimicry ; Phosphoproteins/metabolism ; Phosphorylation ; Protein Conformation/drug effects ; Receptor, Epidermal Growth Factor/metabolism ; Receptor, IGF Type 1/metabolism ; Receptor, Insulin/chemistry/*metabolism ; Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Heterostructures of single-walled carbon nanotubes and carbide nanorods (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-09-11
    Description: A method based on a controlled solid-solid reaction was used to fabricate heterostructures between single-walled carbon nanotubes (SWCNTs) and nanorods or particles of silicon carbide and transition metal carbides. Characterization by high-resolution transmission electron microscopy and electron diffraction indicates that the heterostructures have well-defined crystalline interfaces. The SWCNT/carbide interface, with a nanometer-scale area defined by the cross section of a SWCNT bundle or of a single nanotube, represents the smallest heterojunction that can be achieved using carbon nanotubes, and it can be expected to play an important role in the future fabrication of hybrid nanodevices.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhang -- Ichihashi -- Landree -- Nihey -- Iijima -- New York, N.Y. -- Science. 1999 Sep 10;285(5434):1719-22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Fundamental Research Laboratories, NEC Corporation, 34 Miyukigaoka, Tsukuba, Ibaraki 305-8501, Japan. Department of Materials Science and Engineering, Northwestern University, 2225 North Campus Drive, Evanston, IL 60208, USA. Japan Science and Tec.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10481005" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Organically modified aluminosilicate mesostructures from block copolymer phases (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-12-05
    Description: Organically modified aluminosilicate mesostructures were synthesized from two metal alkoxides with the use of poly(isoprene-b-ethyleneoxide) block copolymers (PI-b-PEO) as the structure-directing molecules. By increasing the fraction of the inorganic precursors with respect to the polymer, morphologies expected from the phase diagrams of diblock copolymers were obtained. The length scale of the microstructures and the state of alignment were varied using concepts known from the study of block copolymers. These results suggest that the use of higher molecular weight block copolymer mesophases instead of conventional low-molecular weight surfactants may provide a simple, easily controlled pathway for the preparation of various silica-type mesostructures that extends the accessible length scale of these structures by about an order of magnitude.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Templin -- Franck -- Du Chesne A -- Leist -- Zhang -- Ulrich -- Schadler V -- Wiesner -- New York, N.Y. -- Science. 1997 Dec 5;278(5344):1795-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max-Planck-Institut fur Polymerforschung, Postfach 3148, 55021 Mainz, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9388181" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Distance-dependent electron transfer in DNA hairpins (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-08-01
    Description: The distance dependence of photoinduced electron transfer in duplex DNA was determined for a family of synthetic DNA hairpins in which a stilbene dicarboxamide forms a bridge connecting two oligonucleotide arms. Investigation of the fluorescence and transient absorption spectra of these hairpins established that no photoinduced electron transfer occurs for a hairpin that has six deoxyadenosine-deoxythymidine base pairs. However, the introduction of a single deoxyguanosine-deoxycytidine base pair resulted in distance-dependent fluorescence quenching and the formation of the stilbene anion radical. Kinetic analysis suggests that duplex DNA is somewhat more effective than proteins as a medium for electron transfer but that it does not function as a molecular wire.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewis, F D -- Wu, T -- Zhang, Y -- Letsinger, R L -- Greenfield, S R -- Wasielewski, M R -- New York, N.Y. -- Science. 1997 Aug 1;277(5326):673-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Northwestern University, Evanston, IL 60208, USA. IL 60439, USA. lewis@chem.nwu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9235887" target="_blank"〉PubMed〈/a〉
    Keywords: Base Composition ; DNA/*chemistry ; *Electrons ; Light ; Models, Molecular ; *Nucleic Acid Conformation ; Oxidation-Reduction ; Spectrometry, Fluorescence ; Spectrum Analysis ; Stilbenes/chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    A Benzene-Thermal Synthetic Route to Nanocrystalline GaN (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-06-28
    Description: A thermal reaction of Li3N and GaCl3 in which benzene was used as the solvent under pressure has been carried out for the preparation of 30-nanometer particles of gallium nitride (GaN) at 280°C. This temperature is much lower than that of traditional methods, and the yield of GaN reached 80%. The x-ray powder diffraction pattern indicated that sample was mainly hexagonal-phase GaN with a small fraction of rocksalt-phase GaN, which has a lattice constant a = 4.100 angstroms. This rocksalt structure, which had been observed previously only under high pressure (at least 37 gigapascals) was observed directly with high-resolution electron microscopy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xie -- Qian -- Wang -- Zhang -- New York, N.Y. -- Science. 1996 Jun 28;272(5270):1926-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Y. Xie and Y. Qian, Structure Research Laboratory and Department of Applied Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China. W. Wang, Department of Applied Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China. S. Zhang and Y. Zhang, Structure Research Laboratory, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8662493" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    On-road vehicle emissions: regulations, costs, and benefits (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-05-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beaton, S P -- Bishop, G A -- Zhang, Y -- Stedman, D H -- Ashbaugh, L L -- Lawson, D R -- New York, N.Y. -- Science. 1995 May 19;268(5213):991-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17774224" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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