Publication Date:
2007-04-21
Description:
Intercellular protein movement plays a critical role in animal and plant development. SHORTROOT (SHR) is a moving transcription factor essential for endodermis specification in the Arabidopsis root. Unlike diffusible animal morphogens, which form a gradient across multiple cell layers, SHR movement is limited to essentially one cell layer. However, the molecular mechanism is unknown. We show that SCARECROW (SCR) blocks SHR movement by sequestering it into the nucleus through protein-protein interaction and a safeguard mechanism that relies on a SHR/SCR-dependent positive feedback loop for SCR transcription. Our studies with SHR and SCR homologs from rice suggest that this mechanism is evolutionarily conserved, providing a plausible explanation why nearly all plants have a single layer of endodermis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cui, Hongchang -- Levesque, Mitchell P -- Vernoux, Teva -- Jung, Jee W -- Paquette, Alice J -- Gallagher, Kimberly L -- Wang, Jean Y -- Blilou, Ikram -- Scheres, Ben -- Benfey, Philip N -- R01-GM043778/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2007 Apr 20;316(5823):421-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology and Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17446396" target="_blank"〉PubMed〈/a〉
Keywords:
Arabidopsis/cytology/genetics/growth & development/*metabolism
;
Arabidopsis Proteins/genetics/*metabolism
;
Biological Evolution
;
Cell Nucleus/metabolism
;
Feedback, Physiological
;
Gene Expression
;
Genes, Plant
;
Models, Biological
;
Oligonucleotide Array Sequence Analysis
;
Oryza/genetics/metabolism
;
Plant Proteins/genetics/metabolism
;
Plant Roots/*cytology/genetics/growth & development/*metabolism
;
Plants, Genetically Modified
;
Promoter Regions, Genetic
;
Protein Binding
;
Protein Transport
;
Recombinant Fusion Proteins/metabolism
;
Transcription Factors/genetics/*metabolism
;
Transcription, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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