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  • 1
    Publication Date: 2024-04-05
    Description: Neuropsychiatric disorders have long been considered as specific dysfunctions of neuronal functions. Studies of the recent decade, however, have challenged this simplistic view, highlighting the important role played by neuroglial cells in the onset and/or progression of neuropsychiatric diseases. In the central nervous system (CNS) non-excitable neuroglia are represented by cells of ectodermal origin (astrocytes, mainly responsible for CNS homeostasis and oligodendrocytes that provide myelination and support for axons) and mesodermal origin (microglial cells that are scions of foetal macrophages entering the neural tube early in development; these cells provide for CNS defence and contribute to shaping neuronal networks). Pathological changes of neuroglia are complex; these changes are classified into reactive gliosis (astrogliosis, activation of microglia and hypertrophy of oligodendroglial precursors), gliodegeneration with loss of function and glial pathological remodelling. Combination of these processes defines the evolution of neurological diseases in general and neuropsychiatric disorders in particular. In this research topic we addressed the contribution of neuroglia to major neuropsychiatric pathologies including major depression, schizophrenia, and addictive disorders.
    Keywords: RC321-571 ; Q1-390 ; Neuropsychiatric Disorders ; Alcohol Use Disorders ; Neurovascular Disorders ; Neuroglia ; Schizophrenia. ; Major Depression ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 2
    Publication Date: 2023-07-25
    Description: Seafloor pressure observations mainly use precise quartz resonant sensors at the present due to its high sensibility. Recently, a new silicon resonant sensor using Micro Electro Mechanical Systems (MEMS) technology has emerged with low-power consumption, compact-size, constant quality, and high sensitivity. High stability is expected due to small size of a sensing unit, and individual difference of each sensors is believed to be small because of using the MEMS technology. Influence of movement of the sensor itself is small due to mechanism of pressure transmission. Nankai Trough seafloor network for earthquakes and tsunamis-net (N-net) will be equipped with the new sensors. Before routine observations using this new sensor, we evaluate performance of the new silicon resonant sensor for seafloor pressure observation. An existing Free-fall pop-up type Ocean Bottom Pressure gauge (OBP) has a quartz resonant sensor. We replaced the sensor to the new silicon sensor, and performed seafloor observations off Boso peninsula near Tokyo. We obtained pressure data from two new sensors. Ambient noise spectra of the new sensor was compared to that of the ordinary sensor which was installed at the same position. The new and ordinary sensors have identical noise level at periods longer than about 50 s. However, the new silicon sensor seems to have higher noise levels at periods between 50 s and 10 s. The new sensor observed sea level fluctuation by volcanic eruption in Tonga and The identical waveforms were obtained from the new and ordinary sensors.
    Language: English
    Type: info:eu-repo/semantics/conferenceObject
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  • 3
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    In:  XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)
    Publication Date: 2023-07-04
    Description: Distributed acoustic sensing (DAS) allows for the deployment of a few tens of meters of seismometers along the length of the optical fiber cable. However, the data obtained from DAS, particularly amplitude information, can vary based on the installation environment of the optical fiber cables. Our proposal is to conduct seismic observations using DAS with optical fiber cables. In this study, we applied DAS to the cable along the bullet train in Kumamoto prefecture, Japan, where aftershocks from the 2016 Mw7.3 Kumamoto earthquake are still highly active. We successfully observed strong motions of the Mj6.6 earthquake on January 22, 2022 in Hyuga-nada and several small local earthquakes for distances over 75 km. An accelerometer that simultaneously recorded the event observed a maximum acceleration of approximately 80 gal. The shaking map (maximum strain distribution) for Mj6.6 was estimated by correcting for cycle skipping caused by the dynamic range. The differential phase data indicated cycle skipping at various channels. We estimated the data from cycle-skipped channels using data from adjacent channels that were not cycle-skipped. The attenuation properties of local earthquakes were identified by correcting for site effects, coupling, and amplification of seismic waves by the railway structure. We observed that the peak strain values as well as PGV decreased with increasing hypocenter distance for each magnitude category. Our results indicate that accurately correcting DAS amplitude values can allow for empirical estimation of earthquake magnitude.
    Language: English
    Type: info:eu-repo/semantics/conferenceObject
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  • 4
    Publication Date: 2023-06-28
    Description: A global kilometer-scale (K-scale) “convection-resolving” model (GCRM) simulation on the climate time scale is one of strategies for the more accuracy of cloud-related processes in the climate system. Against this background and the recent advent of a flagship supercomputer “Fugaku” in Japan, a reliable global K-scale multi-year simulation using the Nonhydrostatic ICosahedral Atmospheric Model (NICAM) is now in sight. While this activity expects the good reproducibility of both climatological statistics and weather disturbances, we also know that this is not straightforward in that there exist resolution-independent model errors at least for O(1–10)-km grid spacing. We have tackled this problem, which partly comes from the poor constraint of a moisture-convection relation contributed by physics-dynamics coupling even in K-scale, via the update and/or tuning of cloud microphysics, unresolved turbulence, and vertical resolutions. In an ongoing AMIP-type 10-year simulation at 3.5-km mesh (about 5 years completed), we have statistically confirmed a successful reproduction of many atmospheric aspects over a wide range of spatio-temporal scales (e.g., mean precipitation and OLR distributions, mid-latitude westerly jets, monsoon, MJO, tropical cyclone intensity, and precipitation diurnal cycle). Meanwhile, we also face several issues for high-resolution climate modeling such as the non-triviality of the appropriate representation of low clouds in K-scale NICAM. In this talk, the above recent progress and challenges in our activity are presented, including the perspectives from process-oriented diagnostics and resolution dependency. A current status of simulations with the ocean-coupled NICAM will also be introduced.
    Language: English
    Type: info:eu-repo/semantics/conferenceObject
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  • 5
    Publication Date: 2023-08-31
    Description: Climate change and increased human activities have resulted in environmental changes such as an increase in evapotranspiration and drought, and the freshwater resources we currently use may not always be available in the same locations in the future. Hence, we need to identify where water resources will be compromised by climate change. The quantification of global water stress through hyper-resolution models necessitates a comprehensive understanding of local water use patterns. The calculation of water stress requires water usage data at a grid-level resolution however, such is frequently lacking in many regions. In this study, we investigated water stress in the Japanese region using global freshwater resources model, H08, by compiling the necessary data for water stress calculations, based on the availability of detailed information on land use, topography, and water use. Water use statistics available at the prefectural and municipal level were downscaled to 1 min resolution. In addition, reservoir operations upstream of the river were incorporated into the model for each purpose. For agricultural water use, in addition to irrigation by water withdrawal from rivers near farmland, the utilization of out-of-basin water sources and conduits systems were also considered. The results reveals that potential high water stress was observed in high population density areas and industrial areas throughout the year. In areas where farmers grow crops, potential high water stress was only observed during the irrigation season. There are 9 out of 47 prefectures in Japan that have potential high water stress, and many of these areas are located in industrial areas.
    Language: English
    Type: info:eu-repo/semantics/conferenceObject
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  • 6
    Publication Date: 2023-01-04
    Description: Highlights • Shear strength in the BPT is estimated based on tensorial strain partitioning. • Accounting for full strain components resolves problems in the two-mechanism model. • Inclination of slip planes causes weakening relative to the friction law. • Fault-parallel compression is significant in the BPT and brittle regimes. A constitutive law of shear zones in the brittle-plastic transition (BPT) is of great importance to understanding loading at the bottom of the seismogenic layer preceding large earthquakes. Previous microphysics-based models are based on the partitioning of slip and dilation normal to the shear zone into different deformation mechanisms. Here, I account for the remaining 2-D strain component, inelastic extension of the shear zone, and associated stress buildup parallel to the shear zone, and investigate the steady-state behavior of a shear zone in which slip on inclined planes and bulk plastic flow coexist. Kinematic constraints and constitutive laws of the two mechanisms were solved numerically. The results show that the inclination of slip planes causes weakening relative to the friction law. Whereas the previous two-mechanism model yields a larger strength than the friction law for a rate-weakening slip element in the BPT, the present model qualitatively resolves this problem. Fault-parallel compression buildup can exceed the normal stress in the BPT and the brittle regime if the friction coefficient of the slip planes is in the range of Byerlee's law. This study illuminates the importance of fault-parallel compression in understanding the fabrics and strengths of shear zones.
    Type: Article , PeerReviewed
    Format: text
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  • 7
    Publication Date: 2023-02-08
    Description: Slow slip events (SSEs) accommodate a significant proportion of tectonic plate motion at subduction zones, yet little is known about the faults that actually host them. The shallow depth (〈2 km) of well-documented SSEs at the Hikurangi subduction zone offshore New Zealand offers a unique opportunity to link geophysical imaging of the subduction zone with direct access to incoming material that represents the megathrust fault rocks hosting slow slip. Two recent International Ocean Discovery Program Expeditions sampled this incoming material before it is entrained immediately down-dip along the shallow plate interface. Drilling results, tied to regional seismic reflection images, reveal heterogeneous lithologies with highly variable physical properties entering the SSE source region. These observations suggest that SSEs and associated slow earthquake phenomena are promoted by lithological, mechanical, and frictional heterogeneity within the fault zone, enhanced by geometric complexity associated with subduction of rough crust.
    Type: Article , PeerReviewed
    Format: text
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  • 8
    Publication Date: 2021-10-28
    Description: Inflammatory bowel disease (IBD) is an autoimmune disease characterized by chronic inflammation of the gastrointestinal tract. IBD includes Crohn’s disease (CD) and ulcerative colitis (UC). CD can occur in any part of the gastrointestinal tract, whereas UC mainly occurs in the colon and rectum. We previously demonstrated that a novel exopolysaccharide (EPS) produced by a plant-derived bacterium, Lactobacillus paracasei IJH-SONE68, prevents and improves the inflammation in contact dermatitis model mice via oral administration. To evaluate the preventive effect of the EPS against other inflammatory diseases, in the present study, we employed dextran sulfate sodium (DSS)-induced UC model mice. The stool consistency, hematochezia, and colonic atrophy of the mice were improved by the orally administered EPS. We also evaluated the cytokine transcription. Overexpression of the mouse macrophage inflammatory protein 2 mRNA in the colon as a functional homolog of human interleukin-8 was decreased by the orally administered EPS. However, the expression of interleukin-10, which is known as an anti-inflammatory cytokine, was stimulated in the EPS-administrated group. Based on these results, we conclude that the IJH-SONE68-derived EPS is a promising lead material for the development of drugs useful in treating inflammatory diseases such as UC.
    Electronic ISSN: 2076-2607
    Topics: Biology
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  • 9
  • 10
    Publication Date: 2021-11-01
    Print ISSN: 0008-6223
    Electronic ISSN: 1873-3891
    Topics: Chemistry and Pharmacology , Geosciences
    Published by Elsevier
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