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  • Articles  (31)
  • 2010-2014
  • 1995-1999  (31)
  • 1997  (31)
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  • Articles  (31)
Source
Keywords
Publisher
Years
  • 2010-2014
  • 1995-1999  (31)
Year
Journal
Topic
  • 1
    Electronic Resource
    Electronic Resource
    3D-QSAR Analysis and Molecular Modeling Investigations of Piritrexim and Analogous (1997)
    Springer
    Journal of molecular modeling 3 (1997), S. 338-346 
    Details
    ISSN: 0948-5023
    Keywords: Keywords: Free-Wilson-analysis ; PLS ; genetic algorithm ; CoMFA ; piritrexim analogous
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Quantitative structure-activity relationships for piritrexim and analogues acting as inhibitors of tumour cell growth have been derived. First the Free-Wilson-method was used on a homologous training set of eight derivatives. The selection of variables important for the biological activity of the compounds was carried out with different multivariate methods as multiple linear regression, the partial least squares method und a genetic algorithm. The derivation of three-dimensional structure activity relationships started with a systematic conformational analysis of all compounds. For the conformations having minimal energy and being in agreement with the crystal structure of piritrexim charges were calculated with the AM1 hamiltonian. For the superimposition of the derivatives two methods were used: maximal similarity of the common substructure or of the molecular fields. A Comparative Molecular Field Analysis with steric and electrostastic fields identified regions important for the activity of the studied compounds independent of the chosen alignment and also correctly predicted the activity of two nonhomologous compounds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s008940050048
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  • 2
    Electronic Resource
    Electronic Resource
    Temperature hysteresis of the change in the cholesteric pitch and surface anchoring in thin planar layers (1997)
    Springer
    Journal of experimental and theoretical physics 85 (1997), S. 285-291 
    Details
    ISSN: 1090-6509
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Hysteresis of the temperature of jumps in the cholesteric pitch in planar layers of cholesteric liquid crystals (CLCs) has been observed in the temperature dependence of the optical transmission spectra measured in a 4.8 ¼m thick specimen of a 60% chiral racemic mixture of CE6. The temperature difference for the pitch jumps during heating and cooling was equal to about 0.1°C near 40.3°C. No difference in the temperature of the pitch jumps during heating and cooling was observed for an 18 µm thick specimen. A theoretical description of this hysteresis is presented on the basis of a continuum theory of elasticity of CLCs that also takes account of the surface anchoring of the CLC. Different possible mechanisms leading to a change in the director configuration in the layer during a pitch jump and their correspondence to the jump mechanism and hysteresis which occur in the experimental specimens are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1134/1.558276
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  • 3
    Electronic Resource
    Electronic Resource
    Total quality "down under": the Australian Quality Award - an innovative model for Business Excellence (1997)
    Bradford : Emerald
    The @TQM magazine 9 (1997), S. 217-220 
    Details
    ISSN: 0954-478X
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: Notes the importance of countries beyond Europe in terms of the contribution of valuable ideas to the development of TQM. Looks at the introduction of the Australian Quality Award and its development from 1988 to the present day. Examines in detail the criteria and purpose of the award.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/09544789710169000
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  • 4
    Electronic Resource
    Electronic Resource
    Continuous formation of supported cubic and hexagonal mesoporous films by sol–gel dip-coating (1997)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 389 (1997), S. 364-368 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Thin films of surfactant-templated mesoporous materials could find applications in membrane-based separations, selective catalysis and sensors. Above the critical micelle concentration of a bulk silica–surfactant solution, films of mesophases with hexagonally packed one-dimensional ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/38699
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  • 5
    Electronic Resource
    Electronic Resource
    Aggregate model of liquids (1997)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 107 (1997), S. 8697-8705 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Atomic-force pictures reveal a heterogeneous microstructure at the surface of glassy layers which should be similar to one of the many equivalent microstructures a liquid is running through. These microstructures are described with the aid of a kinetic model of reversible aggregation which goes back to formulations as used in the description of living polymerization or aggregation of polymers in solution. Aggregates are considered as dynamic subsystems wherein collective modes of motions are excited. Fluctuations of the aggregates, densely packed in a disordered pattern, leads to a broad size distribution which happens to be controlled by Boltzmann's factor. The disordered structure within the aggregates themselves is optimized, reduced aggregate energy and entropy should be equal. Symmetries are deduced which elucidate many universal properties of the dynamic microstructure of liquids. Thermodynamic properties like the specific heats of aggregation in liquids or the dependence of the glass transition of homologues of linear atactic polystyrene are consistently described. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.475022
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  • 6
    Electronic Resource
    Electronic Resource
    Encapsulation of proteins in bulk and thin film sol-gel matrices (1997)
    Springer
    Journal of sol gel science and technology 8 (1997), S. 629-634 
    Details
    ISSN: 1573-4846
    Keywords: protein encapsulation ; absorption spectroscopy ; thin films ; cytochrome c
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract This paper considers the nature of the interactions between the sol-gel derived inorganic matrix and a specific biomolecule, cytochrome c. Optical absorption and impedance spectroscopies are used to characterize the influence of synthesis conditions on the protein’s stability and conformation within the silica matrix. In some instances, encapsulation within the sol-gel matrix provides stabilization. For example, protein denaturation is reversible and aggregation is prevented. Moreover, the drying process does not negatively affect the protein; it is possible to regenerate the aged gel state by rehydration. The flexibility of the sol-gel process enables high quality cytochrome c-doped SiO2 thin films to be prepared. These films possess the characteristic reactivity and chemical function of cytochrome c in solution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02436913
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  • 7
    Electronic Resource
    Electronic Resource
    Spectroscopic determination of cholinesterase activity and inhibition in sol-gel media (1997)
    Springer
    Journal of sol gel science and technology 8 (1997), S. 1067-1070 
    Details
    ISSN: 1573-4846
    Keywords: cholinesterase ; sol-gel ; pesticide ; THA ; enzyme activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Biological activity of cholinesterases can be determined by optically monitoring the enzymatic reaction with indophenyl acetate, (N-4′-acetoxyphenyl)-4-quinone imine. At pH 8.0 cholinesterases hydrolyze this yellow dye to yield a blue reaction product. Cholinesterase inhibitors reduce the rate of this hydrolysis. Thus, by monitoring absorbance of the hydrolysis product at its maximum (630 nm) as a function of time, reaction rates of both cholinesterase activity and cholinesterase inhibition may be quantified spectroscopically. Using this technique, we measured the enzymatic activity of butyrylcholinesterase (BuChE) molecules encapsulated in tetramethyl orthosilicate (TMOS) silicate gel-glass prepared by hydrolysis and condensation. This activity is reduced, in a concentration-dependent manner, by the reversible cholinesterase inhibitors 1,5-bis(4-allyldimethyl-ammoniumphenyl) pentan 3-one dibromide (BADAPP) and 9-amino-1,2,3,4-tetrahydroacridine (THA; tacrine, Cognex). The gel-glasses are rigid, and compact, transparent and porous enough to allow reagents to diffuse in and out.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02436985
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  • 8
    Electronic Resource
    Electronic Resource
    Encapsulation of Proteins in Bulk and Thin Film Sol-Gel Matrices (1997)
    Springer
    Journal of sol gel science and technology 8 (1997), S. 629-634 
    Details
    ISSN: 1573-4846
    Keywords: protein encapsulation ; absorption spectroscopy ; thin films ; cytochrome c
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract This paper considers the nature of the interactions between the sol-gel derived inorganic matrix and a specific biomolecule, cytochrome c. Optical absorption and impedance spectroscopies are used to characterize the influence of synthesis conditions on the protein's stability and conformation within the silica matrix. In some instances, encapsulation within the sol-gel matrix provides stabilization. For example, protein denaturation is reversible and aggregation is prevented. Moreover, the drying process does not negatively affect the protein; it is possible to regenerate the aged gel state by rehydration. The flexibility of the sol-gel process enables high quality cytochrome c-doped SiO2 thin films to be prepared. These films possess the characteristic reactivity and chemical function of cytochrome c in solution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018316108875
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  • 9
    Electronic Resource
    Electronic Resource
    Spectroscopic Determination of Cholinesterase Activity and Inhibition in Sol-Gel Media (1997)
    Springer
    Journal of sol gel science and technology 8 (1997), S. 1067-1070 
    Details
    ISSN: 1573-4846
    Keywords: cholinesterase ; sol-gel ; pesticide ; THA ; enzyme activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Biological activity of cholinesterases can be determined by optically monitoring the enzymatic reaction with indophenyl acetate, (N-4′-acetoxyphenyl)-4-quinone imine. At pH 8.0 cholinesterases hydrolyze this yellow dye to yield a blue reaction product. Cholinesterase inhibitors reduce the rate of this hydrolysis. Thus, by monitoring absorbance of the hydrolysis product at its maximum (630 nm) as a function of time, reaction rates of both cholinesterase activity and cholinesterase inhibition may be quantified spectroscopically. Using this technique, we measured the enzymatic activity of butyrylcholinesterase (BuChE) molecules encapsulated in tetramethyl orthosilicate (TMOS) silicate gel-glass prepared by hydrolysis and condensation. This activity is reduced, in a concentration-dependent manner, by the reversible cholinesterase inhibitors 1,5-bis(4-allyldimethyl-ammoniumphenyl) pentan- 3-one dibromide (BADAPP) and 9-amino-1,2,3,4-tetrahydroacridine (THA; tacrine, Cognex). The gel-glasses are rigid and compact, transparent, and porous enough to allow reagents to diffuse in and out.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018350828807
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  • 10
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    CD4-independent, CCR5-dependent infection of brain capillary endothelial cells by a neurovirulent simian immunodeficiency virus strain (1997)
    National Academy of Sciences
    Details
    Publication Date: 1997-12-23
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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