ISSN:
1420-9071
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Thermal analysis of high salt (0.5 M) washed ribosomal monomers from young and old maleDrosophila melanogaster revealed an 8°C downshift in the mean temperature of denaturation (Tm). Moreover, there was observed a marked loss in the ability of ribosomes extracted from older flies to reassociate upon cooling. These observations suggest that age-dependent alterations in the structural integrity of the rRNA-r protein complex could, at least in part, be responsible for the diminished capacity for protein synthesis in this species with advancing age.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01949936
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