Publication Date:
2014-11-21
Description:
Article Hsp70 and Hsp90 cooperate to fold client proteins, aided by co-chaperones such as Hop. Here Alvira et al . determine EM structures of various combinations of Hsp70, Hsp90, Hop and a client protein to shed structural insight into the mechanism of client protein transfer from one chaperone to the other. Nature Communications doi: 10.1038/ncomms6484 Authors: Sara Alvira, Jorge Cuéllar, Alina Röhl, Soh Yamamoto, Hideaki Itoh, Carlos Alfonso, Germán Rivas, Johannes Buchner, José M. Valpuesta
Electronic ISSN:
2041-1723
Topics:
Biology
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Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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