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  • 1
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    An efficient gene-gene interaction test for genome-wide association studies in trio families (2016)
    Oxford University Press
    Details
    Publication Date: 2016-06-16
    Description: Motivation: Several efficient gene–gene interaction tests have been developed for unrelated case–control samples in genome-wide association studies (GWAS), making it possible to test tens of billions of interaction pairs of single-nucleotide polymorphisms (SNPs) in a reasonable timeframe. However, current family-based gene–gene interaction tests are computationally expensive and are not applicable to genome-wide interaction analysis. Results: We developed an efficient family-based gene–gene interaction test, GCORE, for trios (i.e. two parents and one affected sib). The GCORE compares interlocus correlations at two SNPs between the transmitted and non-transmitted alleles. We used simulation studies to compare the statistical properties such as type I error rates and power for the GCORE with several other family-based interaction tests under various scenarios. We applied the GCORE to a family-based GWAS for autism consisting of approximately 2000 trios. Testing a total of 22 471 383 013 interaction pairs in the GWAS can be finished in 36 h by the GCORE without large-scale computing resources, demonstrating that the test is practical for genome-wide gene–gene interaction analysis in trios. Availability and implementation: GCORE is implemented with C ++ and is available at http://gscore.sourceforge.net . Contact: rchung@nhri.org.tw Supplementary information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
    Published by Oxford University Press
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  • 2
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    An antimicrobial peptide gene found in the male reproductive system of rats (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-03-07
    Description: Little is known about the innate defense mechanisms of the male reproductive tract. We cloned a 385-base pair complementary DNA and its genomic DNA named Bin1b that is exclusively expressed in the caput region of the rat epididymis and that is responsible for sperm maturation, storage, and protection. Bin1b exhibits structural characteristics and antimicrobial activity similar to that of cationic antimicrobial peptides, beta-defensins. Bin1b is maximally expressed when the rats are sexually mature and can be up-regulated by inflammation. Bin1b appears to be a natural epididymis-specific antimicrobial peptide that plays a role in reproductive tract host defense and male fertility.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, P -- Chan, H C -- He, B -- So, S C -- Chung, Y W -- Shang, Q -- Zhang, Y D -- Zhang, Y L -- New York, N.Y. -- Science. 2001 Mar 2;291(5509):1783-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 320, Yue-Yang Road, Shanghai 200031, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11230693" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Cloning, Molecular ; DNA, Complementary ; Epididymis/*immunology/physiology ; Epididymitis/immunology ; Escherichia coli/growth & development ; Gene Expression Profiling ; Gene Expression Regulation, Developmental ; Genes ; Humans ; Male ; Molecular Sequence Data ; Oligonucleotides, Antisense/pharmacology ; RNA, Messenger/genetics/metabolism ; Rats ; Rats, Sprague-Dawley ; Sequence Alignment ; Sexual Maturation ; Spermatozoa/physiology ; Up-Regulation ; beta-Defensins/chemistry/*genetics/pharmacology/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of Perinatal Exposure to Polychlorinated Biphenyls on Development of Female Sexual Behavior (1999)
    Springer
    Bulletin of environmental contamination and toxicology 62 (1999), S. 664-670 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001289900925
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  • 4
    Electronic Resource
    Electronic Resource
    Role of initial conductance and gas pressure on the conductance response of single-crystal SnO2 thin films to H2, O2, and CO (1993)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 73 (1993), S. 8371-8376 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Gas-induced conductance changes were measured on palladium-dosed single-crystal tin oxide (SnO2) thin films having well-characterized surface properties. Films were fabricated using two methods: reactive sputtering and chemical vapor deposition. Film orientation and crystal structure were determined by x-ray diffraction, while surface morphology was characterized using atomic force microscopy. Conductance changes were measured continuously on film surfaces during alternating exposure and evacuation cycles to partial pressures of H2, O2, and CO in a vacuum chamber. The conductance change was found to be proportional to the square root of the initial film conductance and was interpreted in terms of gas-induced changes in the width of a near-surface space-charge layer. The variation of conductance as a function of gas pressure during alternating exposure and evacuation cycles of H2 and O2 is consistent with a model that involves surface reactions between coadsorbates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.353404
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  • 5
    Electronic Resource
    Electronic Resource
    A stress-induced diffusion model for failure of interconnects in microelectronic devices (1991)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 69 (1991), S. 7572-7580 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Voiding and open-circuit failures from cracking of interconnects in microelectronic devices are often observed during isothermal aging and thermal fatigue tests with or without electric current flow. Although the effects of many factors on the failure rate have been investigated experimentally, it is not yet known how to extrapolate the results of accelerated tests to normal operating conditions. Theoretical failure models for isothermal aging and thermal fatigue tests are constructed from diffusion theory and fracture mechanics in this paper. The results from many investigations can be incorporated into this model to explain many of the observed phenomena, for example, effects of the aging temperature, interconnect stress, linewidth, line thickness, passivation, interlayer dielectric stress, etc. Patterned Al-Cu interconnects were thermally cycled in air. It was found that the failure mechanisms of interconnects under isothermal aging and thermal fatigue are the same. Effects of hold time, frequency, and thermal fatigue temperatures on failure rate were studied both experimentally and theoretically. The predicted results according to the present failure model show excellent agreement with experiments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.347525
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  • 6
    Electronic Resource
    Electronic Resource
    A flange-mounted UHV-compatible axial fatigue apparatus using a piezoelectric actuator (1991)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 62 (1991), S. 2008-2010 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The design and construction of a flange-mounted ultra-high vacuum compatible fatigue apparatus using a piezoelectric actuator is described. This apparatus is capable of operation under ambient pressures down to 10−9 Torr. Push-pull fatigue tests can be performed under load, total strain, and plastic strain control at frequencies up to 100 Hz. Control of the fatigue tests and data acquisition are done using standard fatigue control electronics and software.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1142354
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  • 7
    Electronic Resource
    Electronic Resource
    Ultrahigh vacuum apparatus for x-ray powder diffraction in surface science (1998)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 69 (1998), S. 4214-4217 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A laboratory apparatus for surface science and in situ x-ray powder diffraction studies of highly dispersed particles has been constructed. The chamber incorporates standard sample preparation and characterization facilities into a high-flux x-ray diffraction setup, capable of two-circle goniometry with 0.1 nm−1 Q resolution from samples as thin as 1 nm average thickness (1 μg), at an elevated temperature under ultrahigh vacuum, in minutes. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1149233
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  • 8
    Electronic Resource
    Electronic Resource
    Formation of carbon nitride with sp3-bonded carbon in CNx/ZrN superlattice coatings (2000)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 76 (2000), S. 2692-2694 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A carbon nitride phase with primarily sp3-bonded carbon is stabilized in CNx/ZrN superlattice coatings. Rutherford backscattering spectrometry measurements give a N/C atomic ratio ∼1.3 for the CNx layers. High-resolution transmission electron microscopy and Z-contrast imaging from the superlattice show a well-defined layer structure. Raman and near-edge x-ray absorption fine structure spectroscopy results reveal the formation of sp3-bonded carbon atoms in short-period CNx/ZrN superlattices. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.126743
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  • 9
    Electronic Resource
    Electronic Resource
    Composition, structure and tribological properties of amorphous carbon nitride coatings
    Amsterdam : Elsevier
    Surface & Coatings Technology 68-69 (1994), S. 611-615 
    Details
    ISSN: 0257-8972
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0257-8972(94)90225-9
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  • 10
    Electronic Resource
    Electronic Resource
    Changes in tip structure measured during STM lithography
    Amsterdam : Elsevier
    Applied Surface Science 78 (1994), S. 331-338 
    Details
    ISSN: 0169-4332
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0169-4332(94)90022-1
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