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  • 1
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    Stronger proteasomal inhibition and higher CHOP induction are responsible for more effective induction of paraptosis by dimethoxycurcumin than curcumin (2014)
    Springer Nature
    Details
    Publication Date: 2014-03-14
    Description: Stronger proteasomal inhibition and higher CHOP induction are responsible for more effective induction of paraptosis by dimethoxycurcumin than curcumin Cell Death and Disease 5, e1112 (March 2014). doi:10.1038/cddis.2014.85 Authors: M J Yoon, Y J Kang, J A Lee, I Y Kim, M A Kim, Y S Lee, J H Park, B Y Lee, I A Kim, H S Kim, S-A Kim, A-R Yoon, C-O Yun, E-Y Kim, K Lee & K S Choi
    Keywords: dimethoxycurcumincurcuminparaptosismalignant breast cancer cellsproteasomal inhibition
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 2
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    Sobolev-type Lp-approximation orders of radial basis function interpolation to functions in fractional Sobolev spaces (2012)
    Oxford University Press
    Details
    Publication Date: 2012-01-20
    Description: Sobolev-type error analysis has recently been intensively studied for radial basis function interpolation. Although the results have been very successful, some limitations have been found. First, the spaces of target functions are not large enough for thecase $$1\le p\le \mathrm{\infty }$$ to be used practically in some applications. Second, error estimates are confined to the case of finitely smooth radial basis functions. Thus, the primary goal of this paper is to provide Sobolev-type $${L}_{p}$$ -error bounds ( $$1\le p\le \mathrm{\infty }$$ ) to functions in fractional Sobolev spaces for a wide class of radial functions including some infinitely smooth radial functions. Here an infinitely smooth radial function is required to be conditionally positive definite of a certain order $$m 〉 0$$ . In addition we provide numerical results that illustrate our theoretical error bounds.
    Print ISSN: 0272-4979
    Electronic ISSN: 1464-3642
    Topics: Mathematics
    Published by Oxford University Press
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  • 3
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    Visualization of dynamics of single endogenous mRNA labeled in live mouse (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-01-25
    Description: The transcription and transport of messenger RNA (mRNA) are critical steps in regulating the spatial and temporal components of gene expression, but it has not been possible to observe the dynamics of endogenous mRNA in primary mammalian tissues. We have developed a transgenic mouse in which all beta-actin mRNA is fluorescently labeled. We found that beta-actin mRNA in primary fibroblasts localizes predominantly by diffusion and trapping as single mRNAs. In cultured neurons and acute brain slices, we found that multiple beta-actin mRNAs can assemble together, travel by active transport, and disassemble upon depolarization by potassium chloride. Imaging of brain slices revealed immediate early induction of beta-actin transcription after depolarization. Studying endogenous mRNA in live mouse tissues provides insight into its dynamic regulation within the context of the cellular and tissue microenvironment.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111226/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111226/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Park, Hye Yoon -- Lim, Hyungsik -- Yoon, Young J -- Follenzi, Antonia -- Nwokafor, Chiso -- Lopez-Jones, Melissa -- Meng, Xiuhua -- Singer, Robert H -- EB13571/EB/NIBIB NIH HHS/ -- F32-GM87122/GM/NIGMS NIH HHS/ -- GM84364/GM/NIGMS NIH HHS/ -- NS083085-19/NS/NINDS NIH HHS/ -- R01 EB013571/EB/NIBIB NIH HHS/ -- R01 NS083085/NS/NINDS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2014 Jan 24;343(6169):422-4. doi: 10.1126/science.1239200.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24458643" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/*biosynthesis/genetics ; Animals ; Brain/cytology/metabolism ; Cells, Cultured ; Fibroblasts/metabolism ; Fluorescent Dyes/chemistry ; Mice ; Mice, Transgenic ; Neuroimaging/*methods ; Neurons/metabolism ; Protein Biosynthesis ; RNA, Messenger/analysis/biosynthesis/*metabolism ; Staining and Labeling
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Piezoelectric Cylindrical Design for Harvesting Energy in Multi-Directional Vibration Source (2017)
    Institute of Physics (IOP)
    Details
    Publication Date: 2017-09-07
    Description: Vibration Energy Harvester (VEH) has attracted a great attention recently both in academia and industry. One of the most challenging issues in VEH is the possibility to harvest vibration energy in multiple directions. In fact, Conventional VEH (CVEH) using cantilever beam’s structure may possibly become inefficient for the application under multi-directional vibration sources. To overcome this shortcoming of CVEH, this paper proposes a novel design of piezoelectric cylindrical energy harvester (PCEH) which is using patches of piezoelectric material attached to the surface of a cylindrical structure. The Finite Element Method (FEM) analysis using COMSOL Multiphysics software package showed that PCEH has a great potential for the applicability of VEH in the multi-directional vibrating applications such as wearable devices and biomedical devices.
    Print ISSN: 1755-1307
    Electronic ISSN: 1755-1315
    Topics: Geography , Geosciences , Physics
    Published by Institute of Physics (IOP)
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  • 5
    Electronic Resource
    Electronic Resource
    A comparative evaluation method of machinability for mica-based glass-ceramics (1995)
    Springer
    Journal of materials science 30 (1995), S. 1801-1806 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The machinability of mica glass-ceramics is evaluated using a tool dynamometer. Several samples with different chemical compositions and microstructures were tested in turning operations using TiCN cermet tools. The cutting rate dependence of specific cutting energy has been studied to find a simple method for the evaluation of machinability. The mechanical strength, the surface roughness of the machined surface and the fracture toughness were measured to support the machining behaviour. For the determination of machinability, the specific cutting energy at low cutting rate conditions, neglecting an elastic impact effect, and the slope of the log-log plot of the specific cutting energy versus cutting rate were considered as the reasonable parameters. These results are correlated with the microstructure and the hardness of the workpiece. In particular, the microhardness of the sample is shown to control the cutting characteristic.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00351613
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  • 6
    Electronic Resource
    Electronic Resource
    Random excitation of nonlinear coupled oscillators (1990)
    Springer
    Nonlinear dynamics 1 (1990), S. 91-116 
    Details
    ISSN: 1573-269X
    Keywords: internal resonance ; random vibrations ; non-Gaussian closure experiments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract This paper presents the experimental results of random excitation of a nonlinear two-degree-of-freedom system in the neighborhood of internal resonance. The random signals of the excitation and response coordinates are processed to estimate the mean squares, autocorrelation functions, power spectral densities, and probability density functions. The results are qualitatively compared with those predicted by the Fokker-Planck equation together with a non-Gaussian closure scheme. The effects of system damping ratios, nonlinear coupling parameter, internal detuning ratio, and excitation spectral density level are considered in both studies except the effect of damping ratios is not considered in the experimental investigation. Both studies reveal similar dynamic features such as autoparametric absorber effect and stochastic instability of the coupled system. The experimental results show that the autocorrelation function of the coupled system has the feature of ultra narrow band process and degenerates to a periodic one as the internal detuning departs from the exact internal resonance condition. The measured probability density functions of the response of the main system suggests that the Gaussian representation is sufticient as long as the excitation level is relatively low in the neighborhood of the system internal resonance condition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01857587
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  • 7
    Electronic Resource
    Electronic Resource
    Parametric random excitation of nonlinear coupled oscillators (1995)
    Springer
    Nonlinear dynamics 8 (1995), S. 385-413 
    Details
    ISSN: 1573-269X
    Keywords: Parametric excitation ; nonlinear random vibration ; bifurcation and stochastic stability ; experimental testing ; on-off intermittency ; moment closures ; Monte Carlo simulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract The stochastic bifurcation and response statistics of nonlinear modal interaction under parametric random excitation are studied analytically, numerically and experimentally. Two basic definitions of stochastic bifurcation are first introduced. These are bifurcation in distribution and bifurcation in moments. bifurcation in moments is examined for the case of a coupled oscillator subjected to parametric filtered white noise. The center frequency of the excitation is selected to be close to either twice the first mode or second mode natural frequencies or the sum of the two. The stochastic bifurcation in moments is predicted using the Fokker-Planck equation together with gaussian and non-Gaussian closures and numerically using the Monte Carlo simulation. When one mode is parametrically excited it transfers energy to the other mode due to nonlinear modal interaction. The Gaussian closure solution gives close results to those predicted numerically only in regions well remote from bifurcation points. However, bifurcation points predicted by the non-Gaussian closure are in good agreement with those estimated by numerical simulation. Depending on the excitation level, the probability density of the excited mode is strongly non-Gaussian and exhibits multi-maxima as predicted by Monte Carlo simulation. Experimental tests are carried out at relatively low excitation levels. In the neighborhood of stochastic bifurcation in mean square the measured results exhibit different regimes of response characteristics including zero motion and occasional small random motion regimes. These two regimes are characterized by the phenomenon of on-off intermittency. Both regimes overlap and thus it is difficult to locate experimentally the bifurcation point.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00045623
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  • 8
    Electronic Resource
    Electronic Resource
    Effect of the thermodynamic nonideality term (BM1) on the differential molecular volume change in self-associating protein systems (a note on the difference sedimentation equilibrium technique of Springer, Kirschner, and Schachman) (1977)
    New York : Wiley-Blackwell
    Biopolymers 16 (1977), S. 2579-2585 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.1977.360161120
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  • 9
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    Genetic dissection of the biosynthetic route to gentamicin A2 by heterologous expression of its minimal gene set (2008)
    National Academy of Sciences
    Details
    Publication Date: 2008-06-12
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 10
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    Highly reflective MgAl alloy/Ag∕Ru Ohmic contact with low contact resistivity on p-type GaN (2007)
    American Institute of Physics
    Details
    Publication Date: 2007-11-26
    Print ISSN: 0003-6951
    Electronic ISSN: 1077-3118
    Topics: Physics
    Published by American Institute of Physics
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