Publication Date:
2014-04-03
Description:
Canstatin, the noncollagenous domain of collagen type IV α-chains, belongs to a series of collagen-derived angiogenic inhibitors. In this study, the inhibitory effect of recombinant canstatin on tumor growth was investigated using a gastric cancer xenografts model. The volume and weight of tumors in mice treated with canstatin were lower than that in mice treated with PBS. Accordingly, the survival rate of these mice was significantly higher than that of mice bearing tumors treated with PBS. Moreover, valuable insight into the mechanisms mediated by canstatin was obtained.
Print ISSN:
0144-8463
Electronic ISSN:
1573-4935
Topics:
Biology
,
Chemistry and Pharmacology
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