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  • 1
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    Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4 (2016)
    Springer Nature
    Details
    Publication Date: 2016-06-24
    Description: Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4 Cell Death and Disease 7, e2277 (June 2016). doi:10.1038/cddis.2016.181 Authors: J Xiao, Y Pan, X H Li, X Y Yang, Y L Feng, H H Tan, L Jiang, J Feng & X Y Yu
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 2
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    Variation of nectar production in relation to plant characteristics in protandrous Aconitum gymnandrum (2015)
    Oxford University Press
    Details
    Publication Date: 2015-03-28
    Description: Aims Floral nectar plays a vital role in plant reproductive success by attracting pollinators. Nectar traits of a flower can depend directly on plant characteristics other than environmental factors and exhibit extensive flower- and plant-level variations. Studies on nectar traits frequently focused on intraplant variation for dichogamous plants, but few have paid attention to both intra- and interplant nectar variations in relation to plant characteristics. Revealing within- and among-plant variation and its relative magnitude is important for our understanding of how pollinator-mediated selection can act on nectar traits and evolution of nectar traits. Methods Through investigating protandrous Aconitum gymnandrum populations at the Alpine Meadows and Wetland Ecosystems Research Station of Lanzhou University, we examined the relationships between nectar production per flower and plant characteristics (e.g. flower position within inflorescences, floral sexual phases, flowering time, inflorescence size and floral attractive traits). Important Findings A. gymnandrum exhibited a declining gradient in the nectar volume along inflorescences, with more nectar in basal flowers than distal ones. Protandrous flowers of A. gymnandrum did not show gender-biased nectar production while the nectar volume varied with different stages of floral sexual phases. The significant correlation between the first flowering date of individuals and the mean nectar volume per flower was positive in 2013, but became negative in 2014, suggesting complex effects of biotic and abiotic factors. The mean nectar volume per flower was not related to inflorescence size (the number of total flowers per plant). Furthermore, nectar production was weakly associated with floral attractive traits (the petal width and the galea height), even if the effect of flowering time of individuals was removed, suggesting that the honesty of floral traits as signals of nectar reward for pollinators is not stable in this species.
    Print ISSN: 1752-993X
    Electronic ISSN: 1752-9921
    Topics: Biology
    Published by Oxford University Press
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  • 3
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    Formation of high {delta}18O fayalite-bearing A-type granite by high-temperature melting of granulitic metasedimentary rocks, southern China: REPLY (2012)
    Geological Society of America (GSA)
    In: Geology
    Details
    Publication Date: 2012-10-01
    Print ISSN: 0091-7613
    Electronic ISSN: 1943-2682
    Topics: Geosciences
    Published by Geological Society of America (GSA)
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  • 4
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    Temperature, Pressure, and Composition of the Mantle Source Region of Late Cenozoic Basalts in Hainan Island, SE Asia: a Consequence of a Young Thermal Mantle Plume close to Subduction Zones? (2011)
    Oxford University Press
    Details
    Publication Date: 2011-12-23
    Description: Basaltic lavas from Hainan Island near the northern edge of the South China Sea have an age range of between late Miocene (about 13 Ma) and Holocene, with a peak age of late Pliocene to middle Pleistocene. The basaltic province is dominated by tholeiites with subordinate alkali basalts. Most analysed samples display light rare earth element (LREE) enriched REE patterns and ocean island basalt (OIB)-like incompatible element distributions. The basalts contain abundant undeformed high-Mg olivine phenocrysts (up to Fo 90·7 ) that are high in CaO and MnO, indicating high-magnesian parental magmas. Independent barometers indicate that clinopyroxenes in the basalts crystallized over a wide range of pressures of 2–25 kbar (dominantly at 10–15 kbar) and that the melt cooled from about 1350°C to 1100°C during their crystallization. The compositional characteristics of the basalts indicate that their generation most probably involved both low-silica and high-silica melts, as represented by the alkali basalts and tholeiites, respectively. Our results show that the source region for the Hainan basalts is highly heterogeneous. The source for the tholeiites is mainly composed of peridotite and recycled oceanic crust, whereas the source for the bulk of the low-Th alkali basalts consists predominantly of peridotite and low-silica eclogite (garnet pyroxenite). Some high-Th (≥ 4 ppm) alkali basalts may have been produced by partial melting of low-silica garnet pyroxenite (eclogite). We estimated the primary melt compositions for the Hainan basalts using the most forsteritic olivine (Fo 90·7 ) composition and the most primitive bulk-rock samples (MgO 〉 9·0 wt % and CaO 〉8·0 wt %), assuming a constant Fe–Mg exchange partition coefficient of K D = 0·31 and Fe 3+ /Fe T = 0·1. The effective melting pressure ( P f ) and melting temperature ( T ) of the primary melts are P f = 18–32 kbar (weighted average = 23·8 ± 1·8 kbar) and T = 1420–1520°C for the tholeiites, and P f = 25–32 (weighted average = 28·3 ± 1·4 kbar) and T = 1480–1530°C for the alkali basalts. The P f – T data form an array that plots systematically above the dry lherzolite solidus but below the base of the lithosphere (~55 km) and intersects the dry peridotite solidus at a pressure of about 50 kbar. The mantle potential temperature beneath Hainan Island, based on the estimate primary melt compositions, varies from about 1500 to 1580°C with a weighted average of 1541 ± 10°C. The high-magnesian olivine phenocrysts, high mantle potential temperature, and the presence of recycled oceanic crust in the source region provide independent support for the Hainan plume model that has previously been proposed largely based on geophysical observations. The Hainan plume thus provides a rare example of a young mantle plume associated with deep slab subduction.
    Print ISSN: 0022-3530
    Electronic ISSN: 1460-2415
    Topics: Geosciences
    Published by Oxford University Press
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  • 5
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    The B-RafV600E inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury (2014)
    Springer Nature
    Details
    Publication Date: 2014-06-06
    Description: The B-RafV600E inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury Cell Death and Disease 5, e1278 (June 2014). doi:10.1038/cddis.2014.241 Authors: J-X Li, J-M Feng, Y Wang, X-H Li, X-X Chen, Y Su, Y-Y Shen, Y Chen, B Xiong, C-H Yang, J Ding & Z-H Miao
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 6
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    Intermolecular dialkylation of alkenes with two distinct C(sp3)boxhH bonds enabled by synergistic photoredox catalysis and iron catalysis (2019)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2019
    Description: 〈p〉The functionalization of unactivated C(sp〈sup〉3〈/sup〉)H bonds represents one of the most powerful and most atom-economical tools for the formation of new carbon-based chemical bonds in synthesis. Although cross-dehydrogenative coupling reactions of two distinct CH bonds for the formation of carbon-carbon bonds have been well investigated, controlled functionalizations of two or more different C(sp〈sup〉3〈/sup〉)H bonds across a functional group or a molecule (e.g., an alkene or alkyne) in a single reaction remain challenging. Here, we present a three-component dialkylation of alkenes with common alkanes and 1,3-dicarbonyl compounds via synergistic photoredox catalysis and iron catalysis for the synthesis of two functionalized 1,3-dicarbonyl compounds. Mechanistic studies suggest that the photoredox catalysis serves as a promotion system to allow the dialkylation to proceed under mild conditions by reducing the oxidation and reduction potentials of the iron intermediates and the reaction partners.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    The endogenous retrovirus-derived long noncoding RNA TROJAN promotes triple-negative breast cancer progression via ZMYND8 degradation (2019)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2019
    Description: 〈p〉Human endogenous retroviruses (HERVs) play pivotal roles in the development of breast cancer. However, the detailed mechanisms of noncoding HERVs remain elusive. Here, our genome-wide transcriptome analysis of HERVs revealed that a primate long noncoding RNA, which we dubbed TROJAN, was highly expressed in human triple-negative breast cancer (TNBC). TROJAN promoted TNBC proliferation and invasion and indicated poor patient outcomes. We further confirmed that TROJAN could bind to ZMYND8, a metastasis-repressing factor, and increase its degradation through the ubiquitin-proteasome pathway by repelling ZNF592. TROJAN also epigenetically up-regulated metastasis-related genes in multiple cell lines. Correlations between TROJAN and ZMYND8 were subsequently confirmed in clinical samples. Furthermore, our study verified that antisense oligonucleotide therapy targeting TROJAN substantially suppressed TNBC progression in vivo. In conclusion, the long noncoding RNA TROJAN promotes TNBC progression and serves as a potential therapeutic target.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Electron density compression and oscillating effects on laser energy absorption in overdense plasma targets (2014)
    American Physical Society (APS)
    Details
    Publication Date: 2014-03-26
    Description: Author(s): Z. Y. Ge, H. B. Zhuo, W. Yu, X. H. Yang, T. P. Yu, X. H. Li, D. B. Zou, Y. Y. Ma, Y. Yin, F. Q. Shao, and X. J. Peng An analytical model for energy absorption during the interaction of an ultrashort, ultraintense laser with an overdense plasma is proposed. Both the compression effect of the electron density profile and the oscillation of the electron plasma surface are self-consistently included, which exhibit sig... [Phys. Rev. E 89, 033106] Published Tue Mar 25, 2014
    Keywords: Plasma Physics
    Print ISSN: 1539-3755
    Electronic ISSN: 1550-2376
    Topics: Physics
    Published by American Physical Society (APS)
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  • 9
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    Chelyabinsk airburst, damage assessment, meteorite recovery, and characterization (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-11-10
    Description: The asteroid impact near the Russian city of Chelyabinsk on 15 February 2013 was the largest airburst on Earth since the 1908 Tunguska event, causing a natural disaster in an area with a population exceeding one million. Because it occurred in an era with modern consumer electronics, field sensors, and laboratory techniques, unprecedented measurements were made of the impact event and the meteoroid that caused it. Here, we document the account of what happened, as understood now, using comprehensive data obtained from astronomy, planetary science, geophysics, meteorology, meteoritics, and cosmochemistry and from social science surveys. A good understanding of the Chelyabinsk incident provides an opportunity to calibrate the event, with implications for the study of near-Earth objects and developing hazard mitigation strategies for planetary protection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Popova, Olga P -- Jenniskens, Peter -- Emel'yanenko, Vacheslav -- Kartashova, Anna -- Biryukov, Eugeny -- Khaibrakhmanov, Sergey -- Shuvalov, Valery -- Rybnov, Yurij -- Dudorov, Alexandr -- Grokhovsky, Victor I -- Badyukov, Dmitry D -- Yin, Qing-Zhu -- Gural, Peter S -- Albers, Jim -- Granvik, Mikael -- Evers, Laslo G -- Kuiper, Jacob -- Kharlamov, Vladimir -- Solovyov, Andrey -- Rusakov, Yuri S -- Korotkiy, Stanislav -- Serdyuk, Ilya -- Korochantsev, Alexander V -- Larionov, Michail Yu -- Glazachev, Dmitry -- Mayer, Alexander E -- Gisler, Galen -- Gladkovsky, Sergei V -- Wimpenny, Josh -- Sanborn, Matthew E -- Yamakawa, Akane -- Verosub, Kenneth L -- Rowland, Douglas J -- Roeske, Sarah -- Botto, Nicholas W -- Friedrich, Jon M -- Zolensky, Michael E -- Le, Loan -- Ross, Daniel -- Ziegler, Karen -- Nakamura, Tomoki -- Ahn, Insu -- Lee, Jong Ik -- Zhou, Qin -- Li, Xian-Hua -- Li, Qiu-Li -- Liu, Yu -- Tang, Guo-Qiang -- Hiroi, Takahiro -- Sears, Derek -- Weinstein, Ilya A -- Vokhmintsev, Alexander S -- Ishchenko, Alexei V -- Schmitt-Kopplin, Phillipe -- Hertkorn, Norbert -- Nagao, Keisuke -- Haba, Makiko K -- Komatsu, Mutsumi -- Mikouchi, Takashi -- Chelyabinsk Airburst Consortium -- New York, N.Y. -- Science. 2013 Nov 29;342(6162):1069-73. doi: 10.1126/science.1242642. Epub 2013 Nov 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Dynamics of Geospheres of the Russian Academy of Sciences, Leninsky Prospect 38, Building 1, Moscow, 119334, Russia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24200813" target="_blank"〉PubMed〈/a〉
    Keywords: *Accidents ; *Air ; *Explosions ; *Meteoroids ; Russia
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    MHC class I peptides as chemosensory signals in the vomeronasal organ (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-11-06
    Description: The mammalian vomeronasal organ detects social information about gender, status, and individuality. The molecular cues carrying this information remain largely unknown. Here, we show that small peptides that serve as ligands for major histocompatibility complex (MHC) class I molecules function also as sensory stimuli for a subset of vomeronasal sensory neurons located in the basal Gao- and V2R receptor-expressing zone of the vomeronasal epithelium. In behaving mice, the same peptides function as individuality signals underlying mate recognition in the context of pregnancy block. MHC peptides constitute a previously unknown family of chemosensory stimuli by which MHC genotypic diversity can influence social behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leinders-Zufall, Trese -- Brennan, Peter -- Widmayer, Patricia -- S, Prashanth Chandramani -- Maul-Pavicic, Andrea -- Jager, Martina -- Li, Xiao-Hong -- Breer, Heinz -- Zufall, Frank -- Boehm, Thomas -- New York, N.Y. -- Science. 2004 Nov 5;306(5698):1033-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15528444" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Chemoreceptor Cells ; Female ; H-2 Antigens/metabolism ; Histocompatibility Antigens Class I/*metabolism ; Ligands ; Male ; Mice ; Mice, Inbred C57BL ; Olfactory Receptor Neurons/metabolism ; Peptides/*metabolism ; Receptors, Vasopressin/metabolism ; *Signal Transduction ; Smell/physiology ; Urine ; Vomeronasal Organ/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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