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  • 1
    Publication Date: 2011-05-20
    Description: In this work, hexagonal solid solutions of (Gd 0.95 Eu 0.05 )(OH) 3 with two distinctive morphologies of nanorods and nanotubes were successfully synthesized via hydrothermal treatment of mixed nitrate solutions in the presence of ammonium hydroxide. The hydroxide samples exhibited characteristic Eu 3+ photoluminescence through the energy transfer from Gd 3+ to Eu 3+ and the self-excitation of Eu 3+ . The hydroxide precursors transformed into cubic (Gd 0.95 Eu 0.05 ) 2 O 3 at ~500 °C via an intermediate monoclinic (Gd 0.95 Eu 0.05 )OOH phase, and the Eu 3+ coordination accordingly experienced symmetry changes from D 3 h to C 2 v , and then to C 2 / S 6 . The cubic (Gd 0.95 Eu 0.05 ) 2 O 3 well retained the original morphologies of their p...
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 2
    Publication Date: 2017-11-30
    Description: In this paper, the curing kinetics of 4,4′-Methylenebis epoxy resin(TGDDM) and m-Xylylenediamine(m-XDA) was investigated by non-isothermal differential scanning calorimetry(DSC) at various heating rates. Selected non-isothermal methods for analyzing curing kinetics were compared. The activation energy(E) and the correlation coefficient(R) were obtained by different isoconversional methods. The reaction order(n) was obtained by the activation energy in different isoconversional methods for the by Crane equation. The results show that the apparent activation energy are 65.23kJ/mol, 52.20 kJ/mol and 66.10 kJ/mol by using the method of Kissinger, Friedman and F-W-O, the reaction order are 0.911, 0.729 and 0.923 by using the method of Kissinger, Friedman and F-W-O.
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 3
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    In:  Geophys. J. Int., Amsterdam, 4, vol. 105, no. 1-2, pp. 649-657, pp. 1334, (ISSN: 1340-4202)
    Publication Date: 1991
    Keywords: Velocity analysis ; Amplitude ; earth mantle ; Inhomogeneity ; Body waves ; P-waves ; Shear waves ; (The Earth's free) oscillations ; GJI
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  • 4
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    Il Cigno Galileo Galilei
    In:  Professional Paper, Open-File Rept., Earthquake Prediction, Roma, Il Cigno Galileo Galilei, vol. 1, no. 2, pp. 317-332, (ISBN 0080419208)
    Publication Date: 1992
    Keywords: Earthquake precursor: prediction research ; Earthquake precursor: deformation or strain ; Earth tides ; Earthquake precursor: tilt ; JZSCHAU
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  • 5
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    In:  Geophys. Res. Lett., Köln, Elsevier, vol. 13, no. 4, pp. 1549-1552, pp. 1015, (ISSN: 1340-4202)
    Publication Date: 1986
    Keywords: Anisotropy ; Seismology ; (The Earth's free) oscillations ; Earth model, also for more shallow analyses ! ; Tomography ; Inversion ; GRL
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  • 6
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    In:  Nature, Bonn, Inst. f. Theoret. Geodäsie, vol. 325, no. 3-5, pp. 405-409, pp. 1056, (ISBN: 0534351875, 2nd edition)
    Publication Date: 1987
    Keywords: Three dimensional ; (The Earth's free) oscillations ; Spectrum ; Seismology ; NOModelling
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  • 7
    Publication Date: 2014-08-15
    Description: Neurotransmitter-gated ion channels of the Cys-loop receptor family mediate fast neurotransmission throughout the nervous system. The molecular processes of neurotransmitter binding, subsequent opening of the ion channel and ion permeation remain poorly understood. Here we present the X-ray structure of a mammalian Cys-loop receptor, the mouse serotonin 5-HT3 receptor, at 3.5 A resolution. The structure of the proteolysed receptor, made up of two fragments and comprising part of the intracellular domain, was determined in complex with stabilizing nanobodies. The extracellular domain reveals the detailed anatomy of the neurotransmitter binding site capped by a nanobody. The membrane domain delimits an aqueous pore with a 4.6 A constriction. In the intracellular domain, a bundle of five intracellular helices creates a closed vestibule where lateral portals are obstructed by loops. This 5-HT3 receptor structure, revealing part of the intracellular domain, expands the structural basis for understanding the operating mechanism of mammalian Cys-loop receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hassaine, Gherici -- Deluz, Cedric -- Grasso, Luigino -- Wyss, Romain -- Tol, Menno B -- Hovius, Ruud -- Graff, Alexandra -- Stahlberg, Henning -- Tomizaki, Takashi -- Desmyter, Aline -- Moreau, Christophe -- Li, Xiao-Dan -- Poitevin, Frederic -- Vogel, Horst -- Nury, Hugues -- England -- Nature. 2014 Aug 21;512(7514):276-81. doi: 10.1038/nature13552. Epub 2014 Aug 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Laboratory of Physical Chemistry of Polymers and Membranes, Ecole Polytechnique Federale de Lausanne, CH-1015 Lausanne, Switzerland [2] [3] Theranyx, 163 Avenue de Luminy, 13288 Marseille, France. ; 1] Laboratory of Physical Chemistry of Polymers and Membranes, Ecole Polytechnique Federale de Lausanne, CH-1015 Lausanne, Switzerland [2]. ; Laboratory of Physical Chemistry of Polymers and Membranes, Ecole Polytechnique Federale de Lausanne, CH-1015 Lausanne, Switzerland. ; Center for Cellular Imaging and NanoAnalytics, Biozentrum, University of Basel, CH-4058 Basel, Switzerland. ; Swiss Light Source, Paul Scherrer Institute, CH-5234 Villigen, Switzerland. ; Architecture et Fonction des Macromolecules Biologiques, CNRS UMR 7257 and Universite Aix-Marseille, F-13288 Marseille, France. ; 1] Universite Grenoble Alpes, IBS, F-38000 Grenoble, France [2] CNRS, IBS, F-38000 Grenoble, France [3] CEA, DSV, IBS, F-38000 Grenoble, France. ; Laboratory of Biomolecular Research, Paul Scherrer Institute, CH-5232 Villigen, Switzerland. ; Unite de Dynamique Structurale des Macromolecules, Institut Pasteur, CNRS UMR3528, F-75015 Paris, France. ; 1] Laboratory of Physical Chemistry of Polymers and Membranes, Ecole Polytechnique Federale de Lausanne, CH-1015 Lausanne, Switzerland [2] Universite Grenoble Alpes, IBS, F-38000 Grenoble, France [3] CNRS, IBS, F-38000 Grenoble, France [4] CEA, DSV, IBS, F-38000 Grenoble, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25119048" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Binding Sites ; Crystallography, X-Ray ; Mice ; Models, Molecular ; Molecular Sequence Data ; Neurotransmitter Agents/metabolism ; Protein Structure, Quaternary ; Protein Structure, Tertiary ; Protein Subunits/chemistry/metabolism ; Receptors, Serotonin, 5-HT3/*chemistry/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2015-02-07
    Description: Two different confinement transition discharges, the low-intermediate-high (L-I-H) and the low-intermediate-low (L-I-L) confinement transitions, respectively, have been obtained by lower hybrid current drive with lithium wall conditioning in the EAST superconducting tokamak. The dynamic features of short-scale turbulent fluctuations in the two discharges are investigated by a tangential CO 2 laser collective scattering system. It is found that the great changes of broadband fluctuations in amplitude and structure characteristics are closely related to the choice of the final transition to H-mode. These results could shed light on the understanding of the L-H transition mechanism.
    Print ISSN: 1070-664X
    Electronic ISSN: 1089-7674
    Topics: Physics
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  • 9
    Publication Date: 2017-01-10
    Description: Trimethylation of histone H3K36 is a chromatin mark associated with active gene expression, which has been implicated in coupling transcription with mRNA splicing and DNA damage response. SETD2 is a major H3K36 trimethyltransferase, which has been implicated as a tumor suppressor in mammals. Here, we report the regulation of SETD2 protein stability by the proteasome system, and the identification of SPOP, a key subunit of the CUL3 ubiquitin E3 ligase complex, as a SETD2-interacting protein. We demonstrate that SPOP is critically involved in SETD2 stability control and that the SPOP/CUL3 complex is responsible for SETD2 polyubiquitination both in vivo and in vitro . ChIP-Seq analysis and biochemical experiments demonstrate that modulation of SPOP expression confers differential H3K36me3 on SETD2 target genes, and induce H3K36me3-coupled alternative splicing events. Together, these findings establish a functional connection between oncogenic SPOP and tumor suppressive SETD2 in the dynamic regulation of gene expression on chromatin.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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  • 10
    Publication Date: 2015-11-10
    Description: The Handan-Xingtai district in the North China craton is one of the most important concentrations of iron skarn deposits in China, with proven reserves of 900 to 1,000 Mt at an average of 40 to 55 wt % Fe. The iron mineralization occurs predominantly along contact zones between Early Cretaceous intermediate-silicic intrusions and Middle Ordovician marine carbonates intercalated with numerous evaporite beds. In this paper, we present textural features and laser ablation ICP-MS U-Pb dating results of hydrothermal zircon from five major iron skarn deposits to place tight constraints on the timing and duration of the district-scale iron mineralization. Zircon grains from the mineralized skarns are anhedral to subhedral crystals and euhedral tetragonal bipyramids. They are closely intergrown or texturally associated with diopside, garnet, epidote, calcite, albite, and phlogopite. Other common minerals in the skarn assemblages include F-rich hornblende, wilkeite-F, F-apatite, and fluorite. Zircon grains typically contain abundant inclusions of skarn minerals and daughter mineral-rich (mostly magnetite, halite, and sylvite) fluid inclusions. Compositionally, these zircon grains have moderately to extremely high Th (518–7,477 ppm) and U (109–25,610 ppm) contents, with highly variable Th/U ratios ranging from 0.01 to 5.23. The morphological, textural, and geochemical features of the zircons confirm their hydrothermal origin and indicate that they most likely precipitated from high-temperature, F-rich, magmatic-derived ore-forming fluids. The hydrothermal zircon grains yield well-defined concordant U-Pb ages for the five studied iron skarn deposits, with weighted mean 206 Pb/ 238 U dates ranging from 133.6 ± 0.9 to 128.5 ± 1.4 Ma (2 ). These ages are remarkably consistent with U-Pb ages (134.1 ± 1.2 to 128.5 ± 0.9 Ma; 2 ) of magmatic zircon grains from the ore-related intrusions in each deposit, demonstrating that iron skarn mineralization was genetically related to the coeval magmatism. Our new geochronological data, when combined with existing isotopic ages, indicate that iron mineralization and associated magmatism in the Handan-Xingtai district took place mainly at the ca. 137–133 and 131–128 Ma intervals. Iron skarn deposits of similar ages also occur widely in other parts of the eastern North China craton, forming the only known giant Mesozoic iron skarn province in a cratonic block on the Earth. The formation of these iron skarn deposits and associated intrusions coincided in time with lithospheric thinning or destruction of the North China craton, strongly suggesting a causal link between the two processes.
    Print ISSN: 0361-0128
    Topics: Geosciences
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