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  • 1
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    Environmental Pollutant Ozone Causes Damage to Lung Surfactant Protein B (SP-B) (2015)
    American Chemical Society (ACS)
    Details
    Publication Date: 2015-08-14
    Description: Biochemistry DOI: 10.1021/acs.biochem.5b00308
    Print ISSN: 0006-2960
    Electronic ISSN: 1520-4995
    Topics: Biology , Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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  • 2
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    Adsorption of Aerosol-OT to Sapphire: Lamellar Structures Studied with Neutrons (2011)
    American Chemical Society (ACS)
    In: Langmuir
    Details
    Publication Date: 2011-03-29
    Description: Langmuir DOI: 10.1021/la1048985
    Print ISSN: 0743-7463
    Electronic ISSN: 1520-5827
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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  • 3
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    C3-dependent mechanism of microglial priming relevant to multiple sclerosis [Neuroscience] (2012)
    National Academy of Sciences
    Details
    Publication Date: 2012-01-18
    Description: Microglial priming predisposes the brain to neurodegeneration and affects disease progression. The signal to switch from the quiescent to the primed state is unknown. We show that deleting the C3 convertase regulator complement receptor 1-related protein y (Crry) induces microglial priming. Mice that were double-knockout for Crry and either C3 or factor B did not show priming, demonstrating dependence on alternative pathway activation. Colocalization of C3b/iC3b and CR3 implicated the CR3/iC3b interaction in priming. Systemic lipopolysaccharide challenge overactivated primed microglia with florid expression of proinflammatory molecules, which were blocked by complement inhibition. Relevance for neurodegenerative disease is exemplified by human multiple sclerosis (MS) and by experimental autoimmune encephalomyelitis (EAE), a model of MS. In human MS, microglial priming was evident in perilesional white matter, in close proximity to C3b/iC3b deposits. EAE was accelerated and exacerbated in Crry-deficient mice, and was dependent on C activation. In summary, C3-dependent microglial priming confers susceptibility to other challenges. Our observations are relevant to progression in MS and other neurological diseases exacerbated by acute insults.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 4
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    Regulated delivery of therapeutic proteins after in vivo somatic cell gene transfer (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999
    Description: Stable delivery of a therapeutic protein under pharmacologic control was achieved through in vivo somatic gene transfer. This system was based on the expression of two chimeric, human-derived proteins that were reconstituted by rapamycin into a transcription factor complex. A mixture of two adeno-associated virus vectors, one expressing the transcription factor chimeras and one containing erythropoietin (Epo) under the control of a promoter responsive to the transcription factor, was injected into skeletal muscle of immune-competent mice. Administration of rapamycin resulted in 200-fold induction of plasma Epo. Stable engraftment of this humanized system in immune-competent mice was achieved for 6 months with similar results for at least 3 months in a rhesus monkey.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ye, X -- Rivera, V M -- Zoltick, P -- Cerasoli, F Jr -- Schnell, M A -- Gao, G -- Hughes, J V -- Gilman, M -- Wilson, J M -- P01 AR/NS43648-03/AR/NIAMS NIH HHS/ -- P30 DK47757-05/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1999 Jan 1;283(5398):88-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Human Gene Therapy, University of Pennsylvania, Philadelphia, PA 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9872748" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cytomegalovirus/genetics ; Dependovirus/genetics ; Erythropoietin/administration & dosage/blood/*genetics ; Female ; Gene Expression Regulation ; *Gene Transfer Techniques ; Genetic Therapy/*methods ; Genetic Vectors ; Hematocrit ; Injections, Intramuscular ; Macaca mulatta ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Muscle, Skeletal ; Promoter Regions, Genetic ; Recombinant Fusion Proteins ; Recombinant Proteins ; Sirolimus/*pharmacology ; Transcription Factors/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Science in court: head case (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-03-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hughes, Virginia -- England -- Nature. 2010 Mar 18;464(7287):340-2. doi: 10.1038/464340a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20237536" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Antisocial Personality Disorder/physiopathology/psychology ; Child ; Female ; Forensic Sciences/ethics/*methods/trends ; Homicide/*legislation & jurisprudence/*psychology ; Humans ; Insanity Defense ; Magnetic Resonance Imaging/standards/*utilization ; Male ; *Neurosciences ; Positron-Emission Tomography/utilization ; Rape/legislation & jurisprudence/psychology ; Reproducibility of Results
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 6
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    The outlook for a cure (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-07-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hughes, Virginia -- England -- Nature. 2010 Jul 15;466(7304):S11-3. doi: 10.1038/nature09240.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20631696" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/complications/*drug therapy/*virology ; Animals ; Anti-HIV Agents/administration & dosage/adverse effects/pharmacology/therapeutic ; use ; CCR5 Receptor Antagonists ; Disease Reservoirs/virology ; Drug Combinations ; Drug Therapy, Combination ; HIV/*drug effects/enzymology/*isolation & purification ; HIV Infections/complications/*drug therapy/*virology ; HIV Integrase Inhibitors/pharmacology/therapeutic use ; Humans ; Immunologic Memory/drug effects/immunology ; Inflammation/complications/immunology/pathology ; Lymphocyte Activation/drug effects/immunology ; Medication Adherence ; Receptors, CCR5/metabolism ; Survival Analysis ; Treatment Outcome ; Viral Load/*drug effects ; Virus Activation/drug effects/physiology ; Virus Latency/drug effects/physiology ; vif Gene Products, Human Immunodeficiency Virus/antagonists & ; inhibitors/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 7
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    Integrated environmental modelling: achieving the vision (2016)
    Geological Society (of London)
    Details
    Publication Date: 2016-05-25
    Description: Integrated environmental modelling (IEM) is a recent phenomenon that offers the opportunity to solve complex environmental problems. Whilst it has made great strides in recent years, there are still challenges to be met before IEM is universally accepted and used. This paper describes the current state of IEM and sets out a roadmap for achieving its full potential. A multidisciplinary, multi-agency approach will be required, the main goals of which are to: (1) raise awareness and build confidence in IEM; (2) ensure availability and accessibility of IEM techniques, tools and standards; (3) establish a minimum set of standards; (4) build the IEM skills base; (5) establish an underpinning research and development (R&D) programme; (6) co-ordinate and promote collaboration; and (7) foster IEM use by government, industry and the public. Once these goals have been achieved, then IEM can be deployed to help resolve currently intractable environmental issues, and the IEM methodology can be transferred to other fields.
    Print ISSN: 0305-8719
    Electronic ISSN: 2041-4927
    Topics: Geosciences
    Published by Geological Society (of London)
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  • 8
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    Microenvironment: Neighbourhood watch (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hughes, Virginia -- England -- Nature. 2011 Dec 14;480(7377):S48-9. doi: 10.1038/480S48a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22169803" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Marrow Transplantation ; Drug Resistance, Neoplasm/drug effects ; Humans ; Mice ; Mice, SCID ; Multiple Myeloma/*drug therapy/*pathology ; Neoplasm Transplantation ; Tumor Microenvironment/drug effects/*physiology ; Xenograft Model Antitumor Assays
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 9
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    Epidemiology: Complex disorder (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-11-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hughes, Virginia -- England -- Nature. 2012 Nov 1;491(7422):S2-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23136650" target="_blank"〉PubMed〈/a〉
    Keywords: *Autistic Disorder/diagnosis/epidemiology/etiology/genetics/physiopathology ; Humans ; Prevalence ; Synapses/metabolism/pathology ; Twin Studies as Topic
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 10
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    The big fat truth (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-05-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hughes, Virginia -- England -- Nature. 2013 May 23;497(7450):428-30. doi: 10.1038/497428a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23698426" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Body Mass Index ; Cause of Death ; Confounding Factors (Epidemiology) ; Humans ; *Life Expectancy ; Longevity/physiology ; Meta-Analysis as Topic ; Overweight/*mortality ; Public Health/*statistics & numerical data ; Reproducibility of Results ; Sex Factors ; Smoking/epidemiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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