Publication Date:
1994-07-01
Description:
Odorants activate an inward current in vertebrate olfactory receptor cells. Here it is shown, in receptor cells from the newt, that odorants can also suppress this current, by a mechanism that is distinct from inhibition and adaptation. Suppression provides a simple explanation for two seemingly unrelated phenomena: the anomalously long latency of olfactory transduction and the existence of an "off response" at the end of a prolonged stimulus. Suppression may influence the perception of odorants by masking odorant responses and by sharpening the odorant specificities of single cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kurahashi, T -- Lowe, G -- Gold, G H -- New York, N.Y. -- Science. 1994 Jul 1;265(5168):118-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Monell Chemical Senses Center, Philadelphia, PA 19104.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8016645" target="_blank"〉PubMed〈/a〉
Keywords:
Acetophenones/pharmacology
;
Animals
;
Cyclohexenes
;
Membrane Potentials
;
*Odors
;
Olfactory Receptor Neurons/*physiology
;
Pentanols/pharmacology
;
Receptors, Odorant/*physiology
;
Salamandridae
;
*Signal Transduction
;
Terpenes/pharmacology
;
Time Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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