Publication Date:
1993-05-14
Description:
Repeated exposure to olfactory ligands (odorants) increased peripheral olfactory sensitivity in mice. For two unrelated ligands, androstenone and isovaleric acid, induction of olfactory sensitivity was odorant-specific and occurred only in inbred strains that initially had low sensitivity to the exposure odorant. These data demonstrate stimulus-induced plasticity in a sensory receptor cell, suggesting a form of stimulus-controlled gene expression. Induction with two unrelated odorants implies that olfactory induction is a general phenomenon that may occur in a large fraction of the human population.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, H W -- Wysocki, C J -- Gold, G H -- New York, N.Y. -- Science. 1993 May 14;260(5110):998-1000.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Monell Chemical Senses Center, Philadelphia, PA 19104-3308.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8493539" target="_blank"〉PubMed〈/a〉
Keywords:
Androstenes
;
Animals
;
Carrier Proteins/*physiology
;
Mice
;
Mice, Inbred Strains
;
Nasal Mucosa/cytology/*physiology
;
Neuronal Plasticity
;
*Odors
;
Pentanoic Acids
;
*Receptors, Odorant
;
Sensory Receptor Cells/*physiology
;
Sensory Thresholds
;
Smell
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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