ISSN:
1572-8773
Keywords:
Cu-desferrithiocin
;
Crystal structure
;
Superoxide dismutase activity
;
Stability
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Summary A Cu(II) complex of desferrithiocin fromStreptomyces antibioticus was prepared and characterized. The first shell atoms, including one nitrogen and four oxygens, were arranged around the copper in a square-planar pyramide. Due to the axially Jahn-Teller-distorted Cu-O distance at 224.7 pm, a distinct Cu2Zn2superoxide dismutase mimetic activity was measured. The Cu-complex survived 600 μM bovine serum albumin and the thermodynamic stability (pK=17.4) was not very different from that of Cu-EDTA. The electronic absorption properties, circular dichroism and electron paramagnetism were in accordance with those of the type-II copper species.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01138069
Permalink