Summary
A Cu(II) complex of desferrithiocin fromStreptomyces antibioticus was prepared and characterized. The first shell atoms, including one nitrogen and four oxygens, were arranged around the copper in a square-planar pyramide. Due to the axially Jahn-Teller-distorted Cu-O distance at 224.7 pm, a distinct Cu2Zn2superoxide dismutase mimetic activity was measured. The Cu-complex survived 600 μM bovine serum albumin and the thermodynamic stability (pK=17.4) was not very different from that of Cu-EDTA. The electronic absorption properties, circular dichroism and electron paramagnetism were in accordance with those of the type-II copper species.
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Schechinger, T., Hiller, W., Maichle, C. et al. A five-coordinate copper complex with superoxide dismutase mimetic activity fromStreptomyces antibioticus . Biol Metals 1, 112–116 (1988). https://doi.org/10.1007/BF01138069
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DOI: https://doi.org/10.1007/BF01138069