Publication Date:
2017-03-14
Description:
E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses Nature Communications, Published online: 13 March 2017; doi:10.1038/ncomms14654 The innate immune response to many RNA viruses depends on recognition of viral RNA by RIG-I. Here the authors show that, upon virus infection, FBXW7 interacts with RIG-I and inhibits ubiquitin-mediated degradation of RIG-I, resulting in increased interferon signalling in vitro and in vivo .
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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