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  • 1
    Online Resource
    Online Resource
    Geological and Geo-Environmental Processes on Earth (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Natural disasters. ; Physical geography. ; Geochemistry. ; Earth sciences. ; Natural Hazards. ; Earth System Sciences. ; Geochemistry. ; Earth Sciences. ; Earth Sciences.
    Description / Table of Contents: A composite structure of the Bashkir anticlinorium: insights from detrital zircons search in Ordovician sandstones of the Uraltau Uplift, Southern Urals -- Astroblems in the early Earth history: Precambrian impact structures of the Kola-Karelian Region (East Baltic Shield) -- Structure and Geological Processes of the Earth: Examples from the Indian Shield -- World Class Hutti Gold Deposit – an Archean Orogenic Gold Deposit in Hutti-Maski Greenstone belt, Karnataka, India -- Indian Rare-Earth Deposits: related industry, balance problem and Atmnirbhar Bharat -- Petrology and geochemistry of mafic-ultramafic rocks from Taka area, Western Bastar Craton, Central India: An implication for their genesis and mineralization potential -- Metamorphism of the Central Bundelkhand greenstone complex of the Bundelkhand Craton, Indian Shield and its geodynamic setting -- A critical evaluation of the role of geotectonics in groundwater arsenic contamination -- Morphometric and Morphotectonic Studies of Sindh Basin, Central India, using advance techniques of Remote Sensing and GIS -- Landslide Investigations along the road corridor between Nandprayag and Gopeshwar, Chamoli district, Uttarakhand Lesser Himalaya.
    Abstract: This edited volume dedicated to late Prof. P.S. Saklani addresses the multidisciplinary themes pertaining to role of tectonism and magmatism in Crustal Evolution and global distribution of metallic and non metallic mineral deposits. It gives valuable information on geodynamic evolution, structural, petrological, isotopic, metamorphic, geochemical and geochronological attributes of continental and oceanic crust and is challenging reassessments of the existing paradigms. It addresses the implication of magmatism, metallogeny and application of geochronological ages (U-Pb SHRIMP age, Lu-Hf isotopic system; detrital zircons). This book also advocates the role of tectonics in contamination of ground water, and control on drainage pattern and geothermal systems. It explores the vulnerability of earth towards natural hazards viz. earthquakes, floods, cyclones, tsunami, volcanism, cyclones and drought. This volume throws light on the applications of remote sensing, GIS (Geographical Information System) and SRTM data for evaluation of the morphometric and morphotectonic parameters and exploring the susceptibility of river basins toward erosion and flood. It will be beneficial to graduate and post-graduate students as well as professionals and researchers.
    Type of Medium: Online Resource
    Pages: XVIII, 324 p. 167 illus., 137 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811641220
    Series Statement: Springer Natural Hazards,
    URL: https://doi.org/10.1007/978-981-16-4122-0
    DOI: 10.1007/978-981-16-4122-0
    DDC: 551
    Language: English
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  • 2
    Electronic Resource
    Electronic Resource
    New Insights Regarding the Cyclization Pathway for Sterol Biosynthesis from (S)-2,3-Oxidosqualene (1995)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 117 (1995), S. 11819-11820 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00152a030
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  • 3
    Electronic Resource
    Electronic Resource
    A stable and easily prepared catalyst for the enantioselective reduction of ketones. Applications to multistep syntheses (1987)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 109 (1987), S. 7925-7926 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00259a075
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  • 4
    Electronic Resource
    Electronic Resource
    Comparison of the cytotoxic effect of hormonotoxins prepared with the use of heterobifunctional cross-linking agents N-succinimidyl 3-(2-pyridyldithio)propionate and N-succinimidyl 6-[3-(2-pyridyldithio)propionamido]hexanoate (1993)
    s.l. : American Chemical Society
    Bioconjugate chemistry 4 (1993), S. 473-482 
    Details
    ISSN: 1520-4812
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bc00024a009
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  • 5
    Electronic Resource
    Electronic Resource
    Disulfide linked αoLH-gelonin conjugate failed to recombine with βoLH subunit to generate bioeffective hormonotoxin (1993)
    Springer
    Molecular and cellular biochemistry 120 (1993), S. 95-102 
    Details
    ISSN: 1573-4919
    Keywords: gonadotropin ; immunoreactivity ; receptor binding ; steroidogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Since, linking of ovine luteinizing hormone (oLH) to ribosome inactivating protein gelonin (in oLH-gelonin conjugate) occur via the alpha-subunit, αoLH, an attempt has been made to develop a ‘universal’ hormonotoxin for selective targeting to specific cells in the gonads. Four different molar ratios of oLH and N-succinimidyl-3-(2-pyridyldithio) propionate (SPDP) were used to activate the epsilon amino (ψ-NH2) groups of αoLH. The αoLH-SPDP derivatives recombine to native beta subunit of oLH (βoLH) and the purified recombinants retained substantial receptor binding, steroidogenic activity and immunoreactivity to native oLH. The disulfide linked αoLH-S-S-gelonin conjugates prepared by SPDP method were purified by gel filtration chromatography and analysed by reverse-phase high performance liquid chromatography (RP-HPLC). In order to obtain specificity and bioeffectivity, the αoLH-S-S-gelonin conjugates were allowed to recombine to native βoLH and the recombination mixture was further purified by gel-filtration chromatography. The RP-HPLC analysis of these recombinants indicated that αoLH-S-S-gelonin did not recombine to βoLH. The failure of recombination may be due to the reasons. (i) The site of ε-NH2 activation by SPDP may be different in the αoLH than the native oLH. (ii) The activation site may be in close proximity to the annealing site which facilitates the recombination of β-subunit but failured to reassociate to αoLH-S-S-gelonin conjugate. (iii) The introduction of gelonin (30 kDa basic protein) might have induced some steric hinderence for βoLH to recombine to the αoLH site which might have been masked in αoLH-S-S-gelonin conjugates. (Mol Cell Biochem120: 95–102, 1993)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00926081
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  • 6
    Electronic Resource
    Electronic Resource
    Design of liposome to improve encapsulation efficiency of gelonin and its effect on immunoreactivity and ribosome inactivating property (1992)
    Springer
    Molecular and cellular biochemistry 112 (1992), S. 97-109 
    Details
    ISSN: 1573-4919
    Keywords: liposome ; gelonin ; liposome encapsulation ; protein carrier
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Gelonin, purified from the seeds of Gelonium multiflorum, using cation-exchange and gel-filtration chromatography was characterised for its purity, homogeneity and molecular weight by reverse-phase HPLC (RP-HPLC) and SDS-PAGE analysis. The HPLC purified gelonin was used for entrapment studies in the liposomes. Liposomes were prepared by reverse phase evaporation (REV) technique using three different types of lipid composition in the same molar ratio. The method resulted in 75–80% entrapment efficiency of gelonin in the liposomes. Entrapped and unentrapped gelonin was characterized for physico-chemical, immunochemical and biological properties. The immunoreactivity of entrapped gelonin was fully preserved but the ribosome-inactivating property was slightly inhibited. The method involved mild conditions, highly reproducible and the liposomes produced appeared to be stable for several months. It has important implications in the development of cell type specific cytotoxic agents where a chemical cross-linking is involved which significantly inhibits both immunoreactivity and ribosome-inactivating ability of the toxin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00227566
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of amino group modification of ovine luteinizing hormone (oLH) by N-succinimidyl 6-[3-(2-pyridyldithio)propionate]hexanoate, a long chain N-succinimidyl-3-(2-pyridyldithio) propionate (SPDP) on immunological and biological properties: a comparative study with SPDP modified oLH (1994)
    Springer
    Molecular and cellular biochemistry 130 (1994), S. 83-90 
    Details
    ISSN: 1573-4919
    Keywords: Immunoreactivity, ovine luteinizing hormone ; amino group ; subunits ; thiolation ; steroidogenesis ; receptor binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The epsilon-NH2 groups of ovine luteinizing hormone has been modified with the long chain N-succinimidyl-3-(2-pyridyl dithiopropionate (LC-SPDP). The LC-SPDP modification primarily occurs in-NH2 groups of the α-subunit. Although, the sequential modification of lysine residue in α-subunit led to progressive reduction in the receptor binding and immunological properties but the steroidogenic activity was relatively unaffected. The immunoreactivity and receptor binding properties of LC-SPDP modified oLH molecule were more affected comparative to SPDP modified derivatives. This suggested that the increase in hydrophobic carbon chain in LC-SPDP-oLH molecules resulted into the drastic inhibition in the immunological and biological properties. However, the steroidogenic potential of LC-SPDP/or SPDP-oLH derivative was comparable. The present study clearly demonstrate that a single-NH2 group modification with LC-SPDP would generate the site for the conjugation to the toxin/carrier proteins and the resultant oLH-S-S-toxin conjugate would retain significant immunological and biological properties of the hormone molecule. (Mol Cell Biochem130: 83–90, 1994)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01084271
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  • 8
    Electronic Resource
    Electronic Resource
    Effect of chronic microwave radiation on T cell-mediated immunity in the rabbit (1991)
    Springer
    International journal of biometeorology 35 (1991), S. 92-97 
    Details
    ISSN: 1432-1254
    Keywords: Microwave radiation ; Sham exposure ; Delayed type hypersensitivity ; Mitogen responsiveness ; T lymphocyte counts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract Experiments were conducted to elucidate the effects of chronic low power-level microwave radiation on the immunological systems of rabbits. Fourteen male Belgian white rabbits were exposed to microwave radiation at 5 mW/cm2, 2.1 GHz, 3 h daily, 6 days/week for 3 months in two batches of 7 each in specially designed miniature anechoicchambers. Seven rabbits were subjected to sham exposure for identical duration. The microwave energy was provided through S band standard gain horns connected to a 4K3SJ2 Klystron power amplifier. The first batch of animals were assessed for T lymphocyte-mediated cellular immune response mechanisms and the second batch of animals for B lymphocyte-mediated humoral immune response mechanisms. The peripheral blood samples collected monthly during microwave/sham exposure and during follow-up (5/14 days after termination of exposures, in the second batch animals only) were analysed for T lymphocyte numbers and their mitogen responsiveness to ConA and PHA. Significant suppression of T lymphocyte numbers was noted in the microwave group at 2 months (P〈0.01, Δ% 21.5%) and during follow-up (P〈0.01, Δ% 30.2%). The first batch animals were initially sensitised with BCG and challenged with tuberculin (0.03 ml) at the termination of microwave irradiation/sham exposure and the increase in foot pad thickness (Δ mm), which is a measure of T cell-mediated immunity (delayed type hypersensitivity response, DTH) was noted in both the groups. The microwave group revealed a better response than the control group (Δ%+12.4 vs.+7.54). The animals were sacrified and the tissue T lymphocyte counts (spleen and lymph node) were analysed. No significant variation was observed in the tissue T lymphocyte counts of microwave-irradiated rabbits. From these results it is speculated that the T lymphocytes are sequestered to various lymphoid organs under the influence of microwaves. A sub-population of T cells known as T helper cells (mediating DTH response) are probably not affected by microwave radiation. It is clear from our experiments that although chronic microwave radiation at 5 mW/cm2 leads to suppression of peripheral T lymphocyte numbers, there is no concomitant functional impairment of these cells as evidenced by functional assays.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01087483
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  • 9
    Electronic Resource
    Electronic Resource
    Differential refractometry of molecular complexes: A reinvestigation (1982)
    Springer
    Monatshefte für Chemie 113 (1982), S. 557-559 
    Details
    ISSN: 1434-4475
    Keywords: Charge-transfer complexes ; Differential refractometry ; Tetracyanoethylene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Eine modifizierte refraktometrische Methode zur Berechnung von Gleichgewichtskonstanten von Molekülkomplexen wird verwendet und diese mit der Methode vonYoshida undOsawa verglichen.
    Notes: Abstract A modified plot method is used to calculate equilibrium constants of molecular complexes. This method (Sahai andSingh's plot) is compared with the method ofYoshida andOsawa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00800261
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  • 10
    Electronic Resource
    Electronic Resource
    Interaction of some biomolecules with π- and σ-acceptors (1986)
    Springer
    Monatshefte für Chemie 117 (1986), S. 345-350 
    Details
    ISSN: 1434-4475
    Keywords: Charge-transfer complexes ; Ion-pair separation ; Aminoacids ; Genetic bases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Unter Benutzung konduktometrischer, refraktometrischer und differenzrefraktometrischer Methoden wurde die Charge-Transfer-Wechselwirkung einiger biologisch relevanter Moleküle mit Chloranil und Jod und auch ihre Separation in Ionenpaare untersucht. Es wird ein Mechanismus zur Umwandlung des äußeren Komplexes in den inneren vorgeschlagen. Die Koexistenz von zusammenhaftenden und vom Lösungsmittel getrennten Ionenpaaren wird in binären Mischungen von Dioxan—THF nahegelegt. Die GleichgewichtskonstanteK und die Solvatationsnummern wurde für folgende Gleichgewichte errechnet:AAI+, I 3 − +nTHF $$\mathop \rightleftharpoons \limits^K$$ AAI+//I 3 − ;GBI+, I 3 + +nTHF $$\mathop \rightleftharpoons \limits^K$$ AAI+//I 3 − ;GBI+//I 3 − . Dabei wurde herausgefunden, daß ein einzelnesTHF-Molekül zwischen Kation und Anion eingeschoben ist.
    Notes: Abstract Electrical conductance, refractometric and differential refractometric techniques have been used to study the charge-transfer interaction of some biomolecules with chloranil and iodine, and their ion-pair separation. A mechanism of transformation of outer complex to inner complex has been suggested. The coexistence of intimate and solvent-separated ion-pairs in equilibrium in binary mixtures of dioxan—THF is indicated for these complexes. The equilibrium constant (K) and solvation number (n) for the equilibria;AAI+, I 3 − +nTHF $$\mathop \rightleftharpoons \limits^K$$ AAI+//I 3 − ;GBI+, I 3 − +nTHF $$\mathop \rightleftharpoons \limits^K$$ AAI+//I 3 − ;GBI+//I 3 − , have been calculated and it was found that a singleTHF molecule has managed to intercalate between cation and anion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00816528
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