ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Annals of biomedical engineering 21 (1993), S. 407-415 
    ISSN: 1573-9686
    Keywords: Shear-augmented dispersion ; Taylor dispersion ; Non-Newtonian ; Blood rheology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract The rate of spread of a passive species is modified by the superposition of a velocity gradient on the concentration field. Taylor (18) solved for the rate of axial dispersion in fully developed steady Newtonian flow in a straight pipe under the conditions that the dispersion be relatively steady and that longitudinal transport be controlled by convection rather than diffusion. He found that the resulting effective axial diffusivity was proportional to the square of the Peclet numberPec and inversely proportional to the molecular diffusivity. This article shows that under similar conditions in Casson and power law fluids, both simplified models for blood, and in Bingham fluids the same proportionalities are found. Solutions are presented for fully developed steady flow in a straight tube and between flat plates. The proportionality factor, however, is dependent upon the specific rheology of the fluid. For Bingham and Casson fluids, the controlling parameter is the radius of the constant-velocity core in which the shear stress does not exceed the yield stress of the fluid. For a core radius of one-tenth the radius of the tube, the effective axial diffusivity in Casson fluids is reduced to approximately 0.78 times that in a Newtonian fluid at the same flow. Using average flow conditions, it is found that the core radius/tube radius ratio iso(10−2) too(10−1) in canine arteries and veins. Even at these small values, the effective diffusivity is diminished by 5% to 18%. for power law fluids,Pec 2 dependence is again found, but with a proportionality constant dependent upon the power law exponentn. The effective diffusivity in a power law fluid relative to that in a Newtonian fluid is roughly linearly dependent onn for 0〈n〈1. Forn=0.785, representative of human blood, the effective diffusivity reduction is 10% in a circular tube.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1573-9686
    Keywords: Mock circulation ; Hydraulic model ; Heart ; Zero gravity ; Gravity ; Cardiac performance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Results obtained by the investigators in ground-based experiments and in two parabolic flight series of tests aboard the NASA KC-135 aircraft with a hydraulic simulator of the human systemic circulation have confirmed that a simple lack of hydrostatic pressure within an artificial ventricle causes a decrease in stroke volume of 20–50%. A corresponding drop in stroke volume (SV) and cardiac output (CO) was observed over a range of atrial pressures (AP), representing a rightward shift of the classic CO versus AP cardiac function curve. These results are in agreement with echocardiographic experiments performed on space shuttle flights, where an average decrease in SV of 15% was measured following a three-day period of adaptation to weightlessness. The similarity of behavior of the hydraulic model to the human system suggests that the simple physical effects of the lack of hydrostatic pressure may be an important mechanism for the observed changes in cardiac performance in astronauts during the weightlessness of space flight. © 1998 Biomedical Engineering Society. PAC98: 8765+y, 8745Hw
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Annals of biomedical engineering 26 (1998), S. 788-797 
    ISSN: 1573-9686
    Keywords: Blood ; Blood damage ; Shear stress ; Cannula ; Hemolysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Hemolysis in clinical blood samples leads to inaccurate assay results and often to the need for repeated blood draws. In vitro experiments were conducted to determine the influence on hemolysis in phlebotomy needles and catheters of pressure difference, cannula diameter, and cannula material. Fresh blood from five human volunteers was forced from a syringe inside a pressurized chamber through 14, 18, and 22 gauge 304 stainless steel needles and polyurethane and Teflon® catheters, all 40 mm long. Hemolysis was measured in the samples by a spectrophotometer. It was found that hemolysis increased with increases in pressure difference and cannula diameter and no consistent trend could be identified with regard to cannula material. The pressure differences required for significant hemolysis were above those typical of clinical venipuncture blood draws. While there was substantial variability among individuals, the hemolysis values scaled with exponent S=(t/t0)[(τ /τ 0)−1]2, where t is the characteristic duration of shear, t0 is a time constant, τ is the wall shear stress, and τ 0 is the wall shear stress threshold below which no hemolysis occurs. A hemolysis threshold including both time and shear stress was also defined for S=constant. The threshold implies that a threshold shear stress exists below which erythrocytes are not damaged for any length of exposure time, but that red cells may be damaged by an arbitrarily short period of exposure to sufficiently large shear stress. © 1998 Biomedical Engineering Society. PAC98: 8745Hw, 8722-q
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 4
    Publication Date: 2015-05-01
    Print ISSN: 0038-092X
    Electronic ISSN: 1471-1257
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Physics
    Published by Elsevier
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 5
    Publication Date: 2013-01-01
    Print ISSN: 0038-092X
    Electronic ISSN: 1471-1257
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Physics
    Published by Elsevier
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 6
    Publication Date: 2019-02-19
    Description: This study evaluated the building cooling capacity of sky radiation, which was previously identified to have the greatest cooling potential among common ambient sources for climates across the U.S. A heat pipe augmented sky radiator system was simulated by a thermal network with nine nodes, including a thin polyethylene cover with and without condensation, white (zinc oxide) painted radiator plate, condenser and evaporator ends of the heat pipe, thermal storage fluid (water), tank wall, room, sky and ambient air. Heat transfer between nodes included solar flux and sky radiation to cover and plate, wind convection and radiation from cover to ambient, radiation from plate to ambient, natural convection and radiation from plate to cover, conduction from plate to condenser, two-phase heat transfer from evaporator to condenser, natural convection from evaporator to water and from water to tank wall, natural convection and radiation from tank wall to room, and overall heat loss from room to ambient. A thin layer of water was applied to simulate condensation on the cover. Nodal temperatures were simultaneously solved as functions of time using typical meteorological year (TMY3) weather data. Auxiliary cooling was added as needed to limit room temperature to a maximum of 23.9 °C. For this initial investigation, a moderate climate (Louisville, KY) was used to evaluate the effects of radiator orientation, thermal storage capacity, and cooling load to radiator area ratio (LRR). Results were compared to a Louisville baseline with LRR = 10 W/m2 K, horizontal radiator and one cover, which provided an annual sky fraction (fraction of cooling load provided by sky radiation) of 0.855. A decrease to 0.852 was found for an increase in radiator slope to 20 deg, and a drop to 0.832 for 53 deg slope (latitude + 15 deg, a typical slope for solar heating). These drops were associated with increases in average radiator temperature by 0.73 °C for 20 deg and 1.99 °C for 53 deg. A 30% decrease in storage capacity caused a decrease in sky fraction to 0.843. Sky fractions were 0.720 and 0.959 for LRR of 20 and 5, respectively. LRR and thermal storage capacity had strong effects on performance. Radiator slope had a surprisingly small impact, considering that the view factor to the sky at 53 deg tilt is less than 0.5.
    Print ISSN: 0199-6231
    Electronic ISSN: 1528-8986
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 7
    Publication Date: 2017-05-03
    Print ISSN: 0001-1541
    Electronic ISSN: 1547-5905
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Published by Wiley on behalf of American Institute of Chemical Engineers.
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 8
    Publication Date: 2011-08-24
    Description: A numerical model of the cardiovascular system was used to quantify the influences on cardiac function of intrathoracic pressure and intravascular and intraventricular hydrostatic pressure, which are fundamental biomechanical stimuli for orthostatic response. The model included a detailed arterial circulation with lumped parameter models of the atria, ventricles, pulmonary circulation, and venous circulation. The venous circulation was divided into cranial, central, and caudal regions with nonlinear compliance. Changes in intrathoracic pressure and the effects of hydrostatic pressure were simulated in supine, launch, sitting, and standing postures for 0, 1, and 1.8 G. Increasing intrathoracic pressure experienced with increasing gravity caused 12% and 14% decreases in cardiac output for 1 and 1.8 G supine, respectively, compared to 0 G. Similar results were obtained for launch posture, in which the effects of changing intrathoracic pressure dominated those of hydrostatic pressure. Compared to 0 G, cardiac output decreased 0.9% for 1 G launch and 15% for 1.8 G launch. In sitting and standing, the position of the heart above the hydrostatic indifference level caused the effects of changing hydrostatic pressure to dominate those of intrathoracic pressure. Compared to 0 G, cardiac output decreased 13% for 1 G sitting and 23% for 1.8 G sitting, and decreased 17% for 1 G standing and 31% for 1.8 G standing. For a posture change from supine to standing in 1 G, cardiac output decreased, consistent with the trend necessary to explain orthostatic intolerance in some astronauts during postflight stand tests. Simulated lower body negative pressure (LBNP) in 0 G reduced cardiac output and mean aortic pressure similar to I G standing, suggesting that LBNP provides at least some cardiovascular stimuli that may be useful in preventing postflight orthostatic intolerance. A unifying concept, consistent with the Frank-Starling mechanism of the heart, was that cardiac output was proportional to cardiac diastolic transmural pressure for all postures and gravitational accelerations.
    Keywords: Aerospace Medicine
    Type: Annals of biomedical engineering (ISSN 0090-6964); Volume 30; 2; 247-59
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 9
    Publication Date: 2004-12-03
    Description: The objective of this study was to obtain measurement of cutaneous tissue perfusion central and peripheral venous pressure, and esophageal and abdominal pressure in human test subjects during parabolic flight. Hemodynamic data recorded during SLS-I and SLS-2 missions have resulted in the paradoxical finding of increased cardiac stroke volume in the presence of a decreased central venous pressure (CVP) following entry in weightlessness. The investigators have proposed that in the absence of gravity, acceleration-induced peripheral vascular compression is relieved, increasing peripheral vascular capacity and flow while reducing central and peripheral venous pressure, This pilot study seeks to measure blood pressure and flow in human test subjects during parabolic flight for different postures.
    Keywords: Aerospace Medicine
    Type: KC-135 and Other Microgravity Simulations; 11-13; NASA/CR-1999-208922
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 10
    Publication Date: 2013-08-31
    Description: The investigation of cardiovascular adaptation to space flight has seen substantial advancement in the last several years. In-flight echocardiographic measurements of astronaut cardiac function on the Space Shuttle have documented an initial increase, followed by a progressive reduction in both left ventricular volume index and stroke volume with a compensatory increase in heart rate to maintain cardiac output. To date, the reduced cardiac size and stroke volume have been presumed to be the consequence of the reduction in circulating fluid volume within a few days after orbital insertion. However, no specific mechanism for the reduced stroke volume has been identified. The following investigation proposes the use of a hydraulic model of the cardiovascular system to examine the possibility that the observed reduction in stroke volume may, in part, be related to fluid physics effects on heart function. The automated model is being prepared to fly as a Get Away Special (GAS) payload within the next year.
    Keywords: AEROSPACE MEDICINE
    Type: NASA. Goddard Space Flight Center, The 1995 Shuttle Small Payloads Symposium; p 255-256
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...