ISSN:
1434-4475
Keywords:
Keywords. Hexafluoroacetone; Amino acids; Oxazolidin-5-ones; Cuprates; N-Alkylation.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary. A new synthesis of α-N-ethylamino acids starting from α-amino acids using hexafluoroacetone as protecting and activating agent is described. The hexafluoroacetone-protected N-ethylamino acid derivatives obtained are activated lactons. Therefore, they can be directly transformed without the need of an additional activation step with various nucleophiles into the corresponding carboxylic acid derivatives.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s007060070057
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