Summary.
A new synthesis of α-N-ethylamino acids starting from α-amino acids using hexafluoroacetone as protecting and activating agent is described. The hexafluoroacetone-protected N-ethylamino acid derivatives obtained are activated lactons. Therefore, they can be directly transformed without the need of an additional activation step with various nucleophiles into the corresponding carboxylic acid derivatives.
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Received March 24, 2000. Accepted (revised) April 20, 2000
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Schedel, H., Burger, K. Synthesis of α-N-Ethylamino Acids and their Derivatives. Monatshefte für Chemie 131, 1011–1018 (2000). https://doi.org/10.1007/s007060070057
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DOI: https://doi.org/10.1007/s007060070057