ISSN:
1573-8221
Keywords:
mitochondria
;
swelling
;
mitochondrial interaction factor
;
regulation of ion transport
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The effect of mitochondrial interaction factor (MIF) on swelling of the mitochondria in isoosmotic media with KNO3, Ca(NO3)2, and NH4NO3 was studied in the presence of oxidation inhibitors. The total MIF fraction was shown to inhibit swelling of the mitochondria in all three media. By elution of MIF from a DEAE-cellulose column with a pH gradient falling from 8.7 to 6.7, three peaks of activity were obtained (fractions A, B, and C). Quantitative differences were found in the action of these three fractions on swelling of the mitochondria. fraction C inhibited swelling more strongly in Ca(NO3)2, whereas fractions A and B did so in media with KNO3 and NH4NO3.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00797549
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