Publication Date:
1994-07-29
Description:
Interleukin-8 (IL-8) is a proinflammatory cytokine that specifically attracts and activates human neutrophils. A murine gene with a high degree of homology to the two known human IL-8 receptors was cloned and then deleted from the mouse genome by homologous recombination in embryonic stem (ES) cells. These mice, although outwardly healthy, had lymphadenopathy, resulting from an increase in B cells, and splenomegaly, resulting from an increase in metamyelocytes, band, and mature neutrophils. Thus, this receptor may participate in the expansion and development of neutrophils and B cells. This receptor was the major mediator of neutrophil migration to sites of inflammation and may provide a potential therapeutic target in inflammatory disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cacalano, G -- Lee, J -- Kikly, K -- Ryan, A M -- Pitts-Meek, S -- Hultgren, B -- Wood, W I -- Moore, M W -- New York, N.Y. -- Science. 1994 Jul 29;265(5172):682-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Genetics, Genentech, South San Francisco, CA 94080.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8036519" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
B-Lymphocytes/*pathology
;
Bone Marrow/pathology
;
Cell Movement/physiology
;
Chimera
;
Hematopoiesis, Extramedullary/physiology
;
Inflammation/*immunology
;
Leukocyte Count
;
Lymph Nodes/pathology
;
Mice
;
Mice, Inbred C57BL
;
Neutrophils/*pathology
;
Receptors, Interleukin/deficiency/genetics/*physiology
;
Receptors, Interleukin-8B
;
Recombination, Genetic
;
Spleen/pathology
;
Stem Cells
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink