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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1989-09-15
    Description: Locomotion and reaching have traditionally been regarded as separate motor activities. In fact, they may be closely connected both from an evolutionary and a neurophysiological viewpoint. Reaching seems to have evolved from the neural systems responsible for the active and precise positioning of the limb during locomotion; moreover, it seems to be organized in the spinal cord. The motor cortex and its corticospinal outflow are preferentially engaged when precise positioning of the limb is needed during locomotion and are also involved during reaching and active positioning of the hand near objects of interest. All of these motor activities require visuomotor coordination, and it is this coordination that could be achieved by the motor cortex and interconnected parietal and cerebellar areas.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Georgopoulos, A P -- Grillner, S -- NS17413/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1989 Sep 15;245(4923):1209-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Philip Bard Laboratories for Neurophysiology, Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, MD 21205.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2675307" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Forelimb/*physiology ; Humans ; *Locomotion ; *Psychomotor Performance ; Vertebrates/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1998-02-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grillner, S -- New York, N.Y. -- Science. 1997 Nov 7;278(5340):1087-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroscience, Nobel Institute for Neurophysiology, Karolinska Institute, S-171 77 Stockholm, Sweden. sten.grillner@neuro.ki.se〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9381205" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Brain Stem/*physiology ; Interneurons/physiology ; Lampreys/physiology ; Locomotion/*physiology ; Models, Neurological ; Motor Activity/*physiology ; Nerve Net/*physiology ; Potassium Channels/*physiology ; Receptors, N-Methyl-D-Aspartate/physiology ; Spinal Cord/*physiology ; Synaptic Transmission
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-11-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grillner, Sten -- New York, N.Y. -- Science. 2011 Nov 18;334(6058):912-3. doi: 10.1126/science.1214778.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Nobel Institute of Neurophysiology, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden. sten.grillner@ki.se〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22096178" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Humans ; Leg/*physiology ; *Locomotion ; *Motor Activity ; Motor Neurons/*physiology ; Muscle, Skeletal/*physiology ; *Walking
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-02-03
    Description: In the lateral edge of the "white matter" in the lamprey spinal cord, there is a group of nerve cells referred to as edge cells. The results of a combined physiological, light microscopical, and electron microscopical study suggest that these cells serve as intraspinal mechanoreceptors. Edge cells are depolarized on stretch of the lateral margin of the spinal cord, and they have nestlike ramifications in this region oriented in a rostrocaudal plane. These cells exhibit a close structural similarity with the crayfish stretch receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grillner, S -- Williams, T -- Lagerback, P A -- New York, N.Y. -- Science. 1984 Feb 3;223(4635):500-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691161" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/ultrastructure ; Fishes/*anatomy & histology ; Lampreys/*anatomy & histology/physiology ; Mechanoreceptors/*physiology/ultrastructure ; Membrane Potentials ; Neurons/*physiology/ultrastructure ; Spinal Cord/*cytology/physiology ; Synapses/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 1987-04-17
    Description: A new class of excitatory premotor interneurons that are important in the generation of locomotion in the lamprey has now been described. In the isolated spinal cord, these neurons act simultaneously with their postsynaptic motoneurons during fictive swimming. They are small and numerous, and they monosynaptically excite both motoneurons and inhibitory premotor interneurons. The excitatory postsynaptic potentials are depressed by an antagonist of excitatory amino acids. These interneurons receive reticulospinal input from the brain stem and polysynaptic input form skin afferents. A model of the network underlying locomotion based on the synaptic interactions of these neurons can now be proposed for the lamprey.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Buchanan, J T -- Grillner, S -- 5 F32 NS07314-03/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1987 Apr 17;236(4799):312-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3563512" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Electric Stimulation ; Evoked Potentials ; Fishes/*physiology ; Glutamates/*physiology ; Interneurons/cytology/*physiology ; Lampreys/*physiology ; *Locomotion ; Motor Neurons/physiology ; Spinal Cord/cytology/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1985-04-12
    Description: The general principles governing the nervous control of innate motor acts in vertebrates are discussed. Particular consideration is given to the control of locomotion in both mammals and lower vertebrates. One in vitro model of the lamprey central nervous system has been developed. It can be maintained in vitro for several days and the motor pattern underlying locomotion can be elicited in isolated sections of the spinal cord. These findings now allow a detailed analysis of the underlying neural mechanisms. The hypothesis that different parts of the network controlling locomotion can be used in a variety of other motor acts, including learned ones, is reviewed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grillner, S -- New York, N.Y. -- Science. 1985 Apr 12;228(4696):143-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3975635" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Birds/physiology ; Brain Stem/physiology ; Cats ; Cerebellum/physiology ; Crustacea/physiology ; Fishes ; Lampreys/physiology ; *Locomotion ; Mechanoreceptors/physiology ; *Movement ; *Nervous System Physiological Phenomena ; Spinal Cord/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Biological cybernetics 65 (1991), S. 81-90 
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract The use of computer simulations as a neurophysiological tool creates new possibilities to understand complex systems and to test whether a given model can explain experimental findings. Simulations, however, require a detailed specification of the model, including the nerve cell action potential and synaptic transmission. We describe a neuron model of intermediate complexity, with a small number of compartments representing the soma and the dendritic tree, and equipped with Na+, K+, Ca2+, and Ca2+ dependent K+ channels. Conductance changes in the different compartments are used to model conventional excitatory and inhibitory synaptic interactions. Voltage dependent NMDA-receptor channels are also included, and influence both the electrical conductance and the inflow of Ca2+ ions. This neuron model has been designed for the analysis of neural networks and specifically for the simulation of the network generating locomotion in a simple vertebrate, the lamprey. By assigning experimentally established properties to the simulated cells and their synapses, it has been possible to verify the sufficiency of these properties to account for a number of experimental findings of the network in operation. The model is, however, sufficiently general to be useful for realistic simulation also of other neural systems.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract Realistic computer simulations of the experimentally established local spinal cord neural network generating swimming in the lamprey have been performed. Populations of network interneurons were used in which cellular properties, like cell size and membrane conductance including voltage dependent ion channels were randomly distributed around experimentally obtained mean values, as were synaptic conductances (kainate/AMPA, NMDA, glycine) and delays. This population model displayed more robust burst activity over a wider frequency range than the more simple subsample model used previously, and the pattern of interneuronal activity was appropriate. The strength of the reciprocal inhibition played a very important role in the regulation of burst frequency, and just by changing the inhibitory bias the entire physiological range could be covered. At the lower frequency range of bursting the segmental excitatory interneurons provide stability as does the activation of voltage dependent NMDA receptors. Spike frequency adaptation by means of summation of afterhyperpolarization (AHP) serves as a major burst terminating factor, and at lower rates the membrane properties conferred by the NMDA receptor activation. The lateral interneurons were not of critical importance for the burst termination. They may, however, be of particular importance for inducing a rapid burst termination during for instance steering and righting reactions. Several cellular factors combine to provide a secure and stable motor pattern in the entire frequency range.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Neuroscience 14 (1991), S. 169-199 
    ISSN: 0147-006X
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Neuroscience 8 (1985), S. 233-261 
    ISSN: 0147-006X
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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