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  • 1
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    A draft sequence of the rice genome (Oryza sativa L. ssp. japonica) (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-04-06
    Description: The genome of the japonica subspecies of rice, an important cereal and model monocot, was sequenced and assembled by whole-genome shotgun sequencing. The assembled sequence covers 93% of the 420-megabase genome. Gene predictions on the assembled sequence suggest that the genome contains 32,000 to 50,000 genes. Homologs of 98% of the known maize, wheat, and barley proteins are found in rice. Synteny and gene homology between rice and the other cereal genomes are extensive, whereas synteny with Arabidopsis is limited. Assignment of candidate rice orthologs to Arabidopsis genes is possible in many cases. The rice genome sequence provides a foundation for the improvement of cereals, our most important crops.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goff, Stephen A -- Ricke, Darrell -- Lan, Tien-Hung -- Presting, Gernot -- Wang, Ronglin -- Dunn, Molly -- Glazebrook, Jane -- Sessions, Allen -- Oeller, Paul -- Varma, Hemant -- Hadley, David -- Hutchison, Don -- Martin, Chris -- Katagiri, Fumiaki -- Lange, B Markus -- Moughamer, Todd -- Xia, Yu -- Budworth, Paul -- Zhong, Jingping -- Miguel, Trini -- Paszkowski, Uta -- Zhang, Shiping -- Colbert, Michelle -- Sun, Wei-lin -- Chen, Lili -- Cooper, Bret -- Park, Sylvia -- Wood, Todd Charles -- Mao, Long -- Quail, Peter -- Wing, Rod -- Dean, Ralph -- Yu, Yeisoo -- Zharkikh, Andrey -- Shen, Richard -- Sahasrabudhe, Sudhir -- Thomas, Alun -- Cannings, Rob -- Gutin, Alexander -- Pruss, Dmitry -- Reid, Julia -- Tavtigian, Sean -- Mitchell, Jeff -- Eldredge, Glenn -- Scholl, Terri -- Miller, Rose Mary -- Bhatnagar, Satish -- Adey, Nils -- Rubano, Todd -- Tusneem, Nadeem -- Robinson, Rosann -- Feldhaus, Jane -- Macalma, Teresita -- Oliphant, Arnold -- Briggs, Steven -- New York, N.Y. -- Science. 2002 Apr 5;296(5565):92-100.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Torrey Mesa Research Institute, Syngenta, 3115 Merryfield Row, San Diego, CA 92121, USA. stephen.goff@syngenta.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11935018" target="_blank"〉PubMed〈/a〉
    Keywords: Arabidopsis/genetics ; Chromosome Mapping ; Chromosomes/genetics ; Computational Biology ; Conserved Sequence ; DNA, Plant/genetics ; Databases, Nucleic Acid ; Edible Grain/genetics ; Gene Duplication ; Genes, Plant ; *Genome, Plant ; Genomics ; Oryza/*genetics/metabolism/physiology ; Phosphate Transport Proteins/genetics ; Plant Diseases ; Plant Proteins/chemistry/genetics ; Plant Structures/genetics ; Repetitive Sequences, Nucleic Acid ; *Sequence Analysis, DNA ; Sequence Homology, Nucleic Acid ; Software ; Synteny ; Transcription Factors/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-12-04
    Description: The TRIM37 (also known as MUL) gene is located in the 17q23 chromosomal region, which is amplified in up to approximately 40% of breast cancers. TRIM37 contains a RING finger domain, a hallmark of E3 ubiquitin ligases, but its protein substrate(s) is unknown. Here we report that TRIM37 mono-ubiquitinates histone H2A, a chromatin modification associated with transcriptional repression. We find that in human breast cancer cell lines containing amplified 17q23, TRIM37 is upregulated and, reciprocally, the major H2A ubiquitin ligase RNF2 (also known as RING1B) is downregulated. Genome-wide chromatin immunoprecipitation (ChIP)-chip experiments in 17q23-amplified breast cancer cells identified many genes, including multiple tumour suppressors, whose promoters were bound by TRIM37 and enriched for ubiquitinated H2A. However, unlike RNF2, which is a subunit of polycomb repressive complex 1 (PRC1), we find that TRIM37 associates with polycomb repressive complex 2 (PRC2). TRIM37, PRC2 and PRC1 are co-bound to specific target genes, resulting in their transcriptional silencing. RNA-interference-mediated knockdown of TRIM37 results in loss of ubiquitinated H2A, dissociation of PRC1 and PRC2 from target promoters, and transcriptional reactivation of silenced genes. Knockdown of TRIM37 in human breast cancer cells containing amplified 17q23 substantially decreases tumour growth in mouse xenografts. Conversely, ectopic expression of TRIM37 renders non-transformed cells tumorigenic. Collectively, our results reveal TRIM37 as an oncogenic H2A ubiquitin ligase that is overexpressed in a subset of breast cancers and promotes transformation by facilitating silencing of tumour suppressors and other genes.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269325/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269325/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bhatnagar, Sanchita -- Gazin, Claude -- Chamberlain, Lynn -- Ou, Jianhong -- Zhu, Xiaochun -- Tushir, Jogender S -- Virbasius, Ching-Man -- Lin, Ling -- Zhu, Lihua J -- Wajapeyee, Narendra -- Green, Michael R -- R01 GM033977/GM/NIGMS NIH HHS/ -- R01GM033977/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2014 Dec 4;516(7529):116-20. doi: 10.1038/nature13955. Epub 2014 Nov 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA [2] Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA. ; CEA/DSV/iRCM/LEFG, Genopole G2, and Universite Paris Diderot, 91057 Evry, France. ; Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA. ; Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877, USA. ; 1] Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA [2] Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA. ; Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25470042" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Breast Neoplasms/*enzymology/*genetics ; Female ; Gene Expression Profiling ; *Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Gene Silencing ; Heterografts ; Histones/metabolism ; Humans ; MCF-7 Cells ; Mice ; NIH 3T3 Cells ; Nuclear Proteins/*genetics/*metabolism ; Oncogene Proteins/*genetics/metabolism ; Polycomb Repressive Complex 1/*genetics/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
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    Effect of neonatal handling on age-related impairments associated with the hippocampus (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-02-12
    Description: In rats, an environmental manipulation occurring early in life resulted in changes in the adrenocortical axis that persisted throughout the entire life of the animals and attenuated certain deficits associated with aging. Rats handled during infancy had a permanent increase in concentrations of receptors for glucocorticoids in the hippocampus, a critical region in the negative-feedback inhibition of adrenocortical activity. Increased receptor concentrations led to greater hippocampal sensitivity to glucocorticoids and enhanced negative-feedback efficacy in the handled rats. Thus, at all ages tested, rats that were not handled secreted more glucocorticoids in response to stress than did handled rats. At later ages, nonhandled rats also showed elevated basal glucocorticoid levels, with the result that there was a greater cumulative exposure to glucocorticoids in nonhandled rats. Increased exposure to adrenal glucocorticoids can accelerate hippocampal neuron loss and cognitive impairments in aging. Hippocampal cell loss and pronounced spatial memory deficits emerged with age in the nonhandled rats, but were almost absent in the handled rats. Previous work showed that glucocorticoid hypersecretion, hippocampal neuron death, and cognitive impairments form a complex degenerative cascade of aging in the rat. The present study shows that a subtle manipulation early in life can retard the emergence of this cascade.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meaney, M J -- Aitken, D H -- van Berkel, C -- Bhatnagar, S -- Sapolsky, R M -- AG-06633/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1988 Feb 12;239(4841 Pt 1):766-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3340858" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Animals, Newborn ; Dexamethasone/metabolism ; *Handling (Psychology) ; Hippocampus/*growth & development/physiology/physiopathology ; Learning ; Memory ; Rats ; Receptors, Glucocorticoid/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Transient exposure to oxygen or nitrate reveals ecophysiology of fermentative and sulfate-reducing benthic microbial populations (2017)
    WILEY-BLACKWELL PUBLISHING
    In:  EPIC3Environmental Microbiology, WILEY-BLACKWELL PUBLISHING, 19, pp. 4866-4881, ISSN: 1462-2912
    Details
    Publication Date: 2018-02-23
    Description: For the anaerobic remineralization of organic matter in marine sediments, sulfate reduction coupled to fermentation plays a key role. Here, we enriched sulfate-reducing/fermentative communities from intertidal sediments under defined conditions in continuous culture. We transiently exposed the cultures to oxygen or nitrate twice daily and investigated the community response. Chemical measurements, provisional genomes and transcriptomic profiles revealed trophic networks of microbial populations. Sulfate reducers coexisted with facultative nitrate reducers or aerobes enabling the community to adjust to nitrate or oxygen pulses. Exposure to oxygen and nitrate impacted the community structure, but did not suppress fermentation or sulfate reduction as community functions, highlighting their stability under dynamic conditions. The most abundant sulfate reducer in all cultures, related to Desulfotignum balticum, appeared to have coupled both acetate- and hydrogen oxidation to sulfate reduction. We describe a novel representative of the widespread uncultured candidate phylum Fermentibacteria (formerly candidate division Hyd24-12). For this strictly anaerobic, obligate fermentative bacterium, we propose the name 'U Sabulitectum silens' and identify it as a partner of sulfate reducers in marine sediments. Overall, we provide insights into the function of fermentative, as well as sulfate-reducing microbial communities and their adaptation to a dynamic environment.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev , info:eu-repo/semantics/article
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  • 5
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    LOFAR Low-band Antenna Observations of the 3C 295 and Boötes Fields: Source Counts and Ultra-steep Spectrum Sources (2014)
    In:  The Astrophysical Journal
    Details
    Publication Date: 2020-02-12
    Type: info:eu-repo/semantics/article
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  • 6
    Electronic Resource
    Electronic Resource
    Immunity from Cellular Changes in the Blood (1941)
    [s.l.] : Nature Publishing Group
    Nature 147 (1941), S. 58-58 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] CUMULATIVE evidence from a series of investigations on Past, pestis1,2,3, specially in relation to active, passive and natural immunity and bactericidal tests in vitro and in vivo, strongly suggested that the humoral factors could only be partly responsible for host resistance ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/147058a0
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of Polarised Radiations on Animal Metabolism (1926)
    [s.l.] : Nature Publishing Group
    Nature 118 (1926), S. 11-12 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN a previous note (NATURE, February 27, 1926) it was shown that V. cholerœ and B. typhosis grow more rapidly in polarised light than in ordinary light of the same intensity. Further work on the same subject has been continued by us, and a paper embodying the results obtained on the growth of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/118011a0
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  • 8
    Electronic Resource
    Electronic Resource
    The Indian Institute of Science, Bangalore (1924)
    [s.l.] : Nature Publishing Group
    Nature 114 (1924), S. 538-538 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IT is a matter of sincere pleasure to those who are students of science in India to read in NATURE of August 2 an account by Dr. Morris W. Travers of the early working and the history of the Indian Institute of Science. All those who have seen this splendid Institute have a word of praise ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/114538a0
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  • 9
    Electronic Resource
    Electronic Resource
    The Ground State of the Se 2 Molecule (1937)
    [s.l.] : Nature Publishing Group
    Nature 140 (1937), S. 152-152 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE diatomic molecules of the lighter elements of the sixth family of the Periodic Table, like O2, S2, SO, have 3Σ terms as their ground states. There is some doubt if this still prevails with the heavier elements of that group. Spectroscopic investigations have ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/140152b0
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  • 10
    Electronic Resource
    Electronic Resource
    Effects of Polarised Light on Bacterial Growth (1926)
    [s.l.] : Nature Publishing Group
    Nature 117 (1926), S. 302-302 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] DURING recent years certain biochemical effects of polarised light as compared with ordinary light have been brought into prominence by Dr. Elizabeth Sidney Semmens (Journ. Soc. Chem. Ind., 42, 954, 1923; also Bri. Assoc. Rep., 1923). She has shown that the hydrolysis of starch proceeds with ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/117302a0
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