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  • 1
    Electronic Resource
    Electronic Resource
    Separation of amino- and acetylamino-polycyclic aromatic hydrocarbons by reversed- and normal-phase high-performance liquid chromatography
    Amsterdam : Elsevier
    Journal of Chromatography A 461 (1989), S. 327-336 
    Details
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0021-9673(00)94299-7
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    Paper (German National Licenses)
    Fulltext
  • 2
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    A comprehensive study of the open cluster NGC 6866 (2015)
    Oxford University Press
    Details
    Publication Date: 2015-08-25
    Description: We present CCD UBVRI photometry of the field of the open cluster NGC 6866. Structural parameters of the cluster are determined utilizing the stellar density profile of the stars in the field. We calculate the probabilities of the stars being physical members of the cluster, using their astrometric data, and perform further analyses using only the most probable members. The reddening and metallicity of the cluster were determined by independent methods. The LAMOST spectra and the ultraviolet excess of the F- and G-type main-sequence stars in the cluster indicate that the metallicity of the cluster is about the solar value. We estimated the reddening E ( B – V ) = 0.074 ± 0.050 mag using the U – B versus B – V two-colour diagram. The distance modula, the distance and the age of NGC 6866 were derived as μ = 10.60 ± 0.10 mag, d  = 1189 ± 75 pc and t  = 813 ± 50 Myr, respectively, by fitting colour–magnitude diagrams of the cluster with the PARSEC isochrones. The Galactic orbit of NGC 6866 indicates that the cluster is orbiting in a slightly eccentric orbit with e  = 0.12. The mass function slope x  = 1.35 ± 0.08 was derived by using the most probable members of the cluster.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 3
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    O-glycans direct selectin ligands to lipid rafts [Cell Biology] (2015)
    National Academy of Sciences
    Details
    Publication Date: 2015-07-15
    Description: Palmitoylated cysteines typically target transmembrane proteins to domains enriched in cholesterol and sphingolipids (lipid rafts). P-selectin glycoprotein ligand-1 (PSGL-1), CD43, and CD44 are O-glycosylated proteins on leukocytes that associate with lipid rafts. During inflammation, they transduce signals by engaging selectins as leukocytes roll in venules, and they move to the...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 4
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    Potential Cretaceous-Paleogene boundary tsunami deposit in the intra-Tethyan Adriatic carbonate platform section of Hvar (Croatia) (2015)
    Geological Society of America (GSA)
    Details
    Publication Date: 2015-10-28
    Description: An exceptional 47-m-thick succession of Maastrichtian to Paleocene inner-platform carbonates is exposed on the Dalmatian island of Hvar (Adriatic Sea, Croatia) in a seaside locality called Majerovica. The middle part of this succession is an ~5-m-thick intraformational massive deposit, which is underlain by well-bedded peritidal inner-platform limestones containing latest Maastrichtian rudists and shallow-water benthic foraminifera. This deposit includes a polygenic, matrix-supported carbonate breccia characterized by ripped-up platform limestone lithoclasts, up to boulder sized, and polygenic microbreccia in a muddy matrix. The microbreccia contains rare small intraclasts of pelagic mudstone containing terminal Maastrichtian planktonic foraminifera. The deposit is overlain in turn by mudstone containing a planktonic foraminiferal association belonging to the P0 and Pα zones of the basal Paleogene, and by shallow-water muddy limestones containing planktonic foraminifera belonging to the P1 zone. While facies suggest that the deposit was emplaced over the inner platform by a single large tsunami, the biostratigraphic assessment of this section and the presence of enhanced concentrations of platinum group elements, such as iridium, in the topmost part of the massive deposit lend support to the hypothesis that this tsunamite is related to the Chicxulub impact in Yucatán. This is potentially the first case of a tropical carbonate platform sedimentary succession recording the Cretaceous-Paleogene boundary event, which provides a new constraint for modeling both the western Tethyan paleogeography and the catastrophic aftermaths of the Chicxulub impact at the end of the Mesozoic Era.
    Print ISSN: 0016-7606
    Electronic ISSN: 1943-2674
    Topics: Geosciences
    Published by Geological Society of America (GSA)
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  • 5
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    The Mouse Universal Genotyping Array: From Substrains to Subspecies (2016)
    Genetics Society of America (GSA)
    Details
    Publication Date: 2016-02-05
    Description: Genotyping microarrays are an important resource for genetic mapping, population genetics, and monitoring of the genetic integrity of laboratory stocks. We have developed the third generation of the Mouse Universal Genotyping Array (MUGA) series, GigaMUGA, a 143,259-probe Illumina Infinium II array for the house mouse ( Mus musculus ). The bulk of the content of GigaMUGA is optimized for genetic mapping in the Collaborative Cross and Diversity Outbred populations, and for substrain-level identification of laboratory mice. In addition to 141,090 single nucleotide polymorphism probes, GigaMUGA contains 2006 probes for copy number concentrated in structurally polymorphic regions of the mouse genome. The performance of the array is characterized in a set of 500 high-quality reference samples spanning laboratory inbred strains, recombinant inbred lines, outbred stocks, and wild-caught mice. GigaMUGA is highly informative across a wide range of genetically diverse samples, from laboratory substrains to other Mus species. In addition to describing the content and performance of the array, we provide detailed probe-level annotation and recommendations for quality control.
    Electronic ISSN: 2160-1836
    Topics: Biology
    Published by Genetics Society of America (GSA)
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  • 6
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    Highly variable recessive lethal or nearly lethal mutation rates during germ-line development of male Drosophila melanogaster [Evolution] (2011)
    National Academy of Sciences
    Details
    Publication Date: 2011-09-21
    Description: Each cell of higher organism adults is derived from a fertilized egg through a series of divisions, during which mutations can occur. Both the rate and timing of mutations can have profound impacts on both the individual and the population, because mutations that occur at early cell divisions will affect more tissues and are more likely to be transferred to the next generation. Using large-scale multigeneration screening experiments for recessive lethal or nearly lethal mutations of Drosophila melanogaster and recently developed statistical analysis, we show for male D. melanogaster that (i) mutation rates (for recessive lethal or nearly lethal) are highly variable during germ cell development; (ii) first cell cleavage has the highest mutation rate, which drops substantially in the second cleavage or the next few cleavages; (iii) the intermediate stages, after a few cleavages to right before spermatogenesis, have at least an order of magnitude smaller mutation rate; and (iv) spermatogenesis also harbors a fairly high mutation rate. Because germ-line lineage shares some (early) cell divisions with somatic cell lineage, the first conclusion is readily extended to a somatic cell lineage. It is conceivable that the first conclusion is true for most (if not all) higher organisms, whereas the other three conclusions are widely applicable, although the extent may differ from species to species. Therefore, conclusions or analyses that are based on equal mutation rates during development should be taken with caution. Furthermore, the statistical approach developed can be adopted for studying other organisms, including the human germ-line or somatic mutational patterns.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 7
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    De Novo Transcriptome Sequence Assembly from Coconut Leaves and Seeds with a Focus on Factors Involved in RNA-Directed DNA Methylation (2014)
    Genetics Society of America (GSA)
    Details
    Publication Date: 2014-11-15
    Description: Coconut palm ( Cocos nucifera ) is a symbol of the tropics and a source of numerous edible and nonedible products of economic value. Despite its nutritional and industrial significance, coconut remains under-represented in public repositories for genomic and transcriptomic data. We report de novo transcript assembly from RNA-seq data and analysis of gene expression in seed tissues (embryo and endosperm) and leaves of a dwarf coconut variety. Assembly of 10 GB sequencing data for each tissue resulted in 58,211 total unigenes in embryo, 61,152 in endosperm, and 33,446 in leaf. Within each unigene pool, 24,857 could be annotated in embryo, 29,731 could be annotated in endosperm, and 26,064 could be annotated in leaf. A KEGG analysis identified 138, 138, and 139 pathways, respectively, in transcriptomes of embryo, endosperm, and leaf tissues. Given the extraordinarily large size of coconut seeds and the importance of small RNA-mediated epigenetic regulation during seed development in model plants, we used homology searches to identify putative homologs of factors required for RNA-directed DNA methylation in coconut. The findings suggest that RNA-directed DNA methylation is important during coconut seed development, particularly in maturing endosperm. This dataset will expand the genomics resources available for coconut and provide a foundation for more detailed analyses that may assist molecular breeding strategies aimed at improving this major tropical crop.
    Electronic ISSN: 2160-1836
    Topics: Biology
    Published by Genetics Society of America (GSA)
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  • 8
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    NDV-3 vaccine efficacy versus MRSA [Immunology and Inflammation] (2014)
    National Academy of Sciences
    Details
    Publication Date: 2014-12-24
    Description: Increasing rates of life-threatening infections and decreasing susceptibility to antibiotics urge development of an effective vaccine targeting Staphylococcus aureus. This study evaluated the efficacy and immunologic mechanisms of a vaccine containing a recombinant glycoprotein antigen (NDV-3) in mouse skin and skin structure infection (SSSI) due to methicillin-resistant S. aureus (MRSA)....
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 9
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    Pattern of Mutation Rates in the Germline of Drosophila melanogaster Males from a Large-Scale Mutation Screening Experiment (2014)
    Genetics Society of America (GSA)
    Details
    Publication Date: 2014-08-14
    Description: The sperm or eggs of sexual organisms go through a series of cell divisions from the fertilized egg; mutations can occur at each division. Mutations in the lineage of cells leading to the sperm or eggs are of particular importance because many such mutations may be shared by somatic tissues and also may be inherited, thus having a lasting consequence. For decades, little has been known about the pattern of the mutation rates along the germline development. Recently it was shown from a small portion of data that resulted from a large-scale mutation screening experiment that the rates of recessive lethal or nearly lethal mutations differ dramatically during the germline development of Drosophila melanogaster males. In this paper the full data set from the experiment and its analysis are reported by taking advantage of a recent methodologic advance. By analyzing the mutation patterns with different levels of recessive lethality, earlier published conclusions based on partial data are found to remain valid. Furthermore, it is found that for most nearly lethal mutations, the mutation rate at the first cell division is even greater than previous thought compared with those at other divisions. There is also some evidence that the mutation rate at the second division decreases rapidly but is still appreciably greater than those for the rest of the cleavage stage. The mutation rate at spermatogenesis is greater than late cleavage and stem-cell stages, but there is no evidence that rates are different among the five cell divisions of the spermatogenesis. We also found that a modestly biased sampling, leading to slightly more primordial germ cells after the eighth division than those reported in the literature, provides the best fit to the data. These findings provide conceptual and numerical basis for exploring the consequences of differential mutation rates during individual development.
    Electronic ISSN: 2160-1836
    Topics: Biology
    Published by Genetics Society of America (GSA)
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  • 10
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    Langerhans cells facilitate epithelial DNA damage and squamous cell carcinoma (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-01-10
    Description: Polyaromatic hydrocarbons (PAHs) are prevalent, potent carcinogens, and 7,12-dimethylbenz[a]anthracene (DMBA) is a model PAH widely used to study tumorigenesis. Mice lacking Langerhans cells (LCs), a signatory epidermal dendritic cell (DC), are protected from cutaneous chemical carcinogenesis, independent of T cell immunity. Investigation of the underlying mechanism revealed that LC-deficient skin was relatively resistant to DMBA-induced DNA damage. LCs efficiently metabolized DMBA to DMBA-trans-3,4-diol, an intermediate proximal to oncogenic Hras mutation, and DMBA-treated LC-deficient skin contained significantly fewer Hras mutations. Moreover, DMBA-trans-3,4-diol application bypassed tumor resistance in LC-deficient mice. Additionally, the genotoxic impact of DMBA on human keratinocytes was significantly increased by prior incubation with human-derived LC. Thus, tissue-associated DC can enhance chemical carcinogenesis via PAH metabolism, highlighting the complex relation between immune cells and carcinogenesis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753811/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753811/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Modi, Badri G -- Neustadter, Jason -- Binda, Elisa -- Lewis, Julia -- Filler, Renata B -- Roberts, Scott J -- Kwong, Bernice Y -- Reddy, Swapna -- Overton, John D -- Galan, Anjela -- Tigelaar, Robert -- Cai, Lining -- Fu, Peter -- Shlomchik, Mark -- Kaplan, Daniel H -- Hayday, Adrian -- Girardi, Michael -- 085780/Wellcome Trust/United Kingdom -- K08 AR002072/AR/NIAMS NIH HHS/ -- P30 CA016359/CA/NCI NIH HHS/ -- R01 AR056632/AR/NIAMS NIH HHS/ -- R01 CA102703/CA/NCI NIH HHS/ -- R01-AR044077/AR/NIAMS NIH HHS/ -- R01-AR056632/AR/NIAMS NIH HHS/ -- R01CA102703/CA/NCI NIH HHS/ -- T32 AR007016/AR/NIAMS NIH HHS/ -- Cancer Research UK/United Kingdom -- Department of Health/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2012 Jan 6;335(6064):104-8. doi: 10.1126/science.1211600.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22223807" target="_blank"〉PubMed〈/a〉
    Keywords: 9,10-Dimethyl-1,2-benzanthracene/*analogs & derivatives/metabolism/toxicity ; Animals ; Aryl Hydrocarbon Hydroxylases/metabolism ; Carcinogens/*metabolism/*toxicity ; Carcinoma, Squamous Cell/*chemically induced/metabolism ; Cell Transformation, Neoplastic ; Cells, Cultured ; Cytochrome P-450 CYP1A1/metabolism ; Cytochrome P-450 CYP1B1 ; *DNA Damage ; Genes, ras ; Humans ; Keratinocytes/metabolism/pathology ; Langerhans Cells/immunology/*metabolism ; Mice ; Mice, Transgenic ; Skin Neoplasms/*chemically induced/metabolism ; T-Lymphocytes/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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