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  • 1
    Online Resource
    Online Resource
    Microbiome in Inflammatory Lung Diseases (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Microbial populations. ; Inflammation. ; Respiratory organs. ; Physiology. ; Cancer. ; Microbial Communities. ; Inflammation. ; Respiratory Physiology. ; Cancer Biology.
    Description / Table of Contents: Introduction to Lung Diseases -- Introduction to Microbiome -- Role of Microbiome in Inflammation -- The interplay of microbiome, inflammation, and immunity in inflammatory lung diseases -- Microbiome in Asthma -- Microbiome in Chronic Obstructive Pulmonary Disease -- Microbiome in Asthma-COPD Overlap syndrome (ACO) -- Microbiome in ARDS (Acute Respiratory Distress Syndrome) -- Role of brain-gut- microbiome axis in Depression co-morbid with COPD or Asthma -- Microbiome in Lung Cancer -- Microbiome in Pulmonary Tuberculosis -- Lung Microbiome: Friend or Foe of Mycobacterium tuberculosis -- Microbiome in Idiopathic Pulmonary Fibrosis. Microbiome in SARS-Cov2 (Covid-19) -- Status of the microbiome in SARS-Cov2 (Covid-19) -- Microbiome in Influenza-A Virus Infection -- Microbiome in Upper Respiratory Tract Infection (URTI) -- Challenges in understanding the lung microbiota -- Microbiome in Inflammatory Lung Diseases: Challenges and Future Prospects -- Microbiota targeted via nanotechnology for lung cancer therapy: Challenges and future perspectives.
    Abstract: This book reviews the role of the lung microbiome in the development and progression of lung diseases. It deals with the role of microbiota dysbiosis in influencing host defense and immunity leading to resistance, colonization, and disease exacerbation. The book delineates the complex interaction between pathogen and lung residual microbiota during disease conditions. It further highlights the potential role of lung microbiota as the key modulator of lung carcinogenesis and immune response against cancer cells. Lastly, it reviews technological developments for unraveling the lung microbiome that profoundly impacts clinical diagnostics. This book is an essential resource for the scientists working in pulmonary diseases, pharmaceutical & clinical sciences, and pulmonary clinicians.
    Type of Medium: Online Resource
    Pages: XIV, 377 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811689574
    URL: https://doi.org/10.1007/978-981-16-8957-4
    DOI: 10.1007/978-981-16-8957-4
    DDC: 579.1788
    Language: English
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    E-BOOKS (AWI ONLY)
  • 2
    Online Resource
    Online Resource
    Targeting Epigenetics in Inflammatory Lung Diseases (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Epigenetics. ; Respiratory organs. ; Physiology. ; Pharmacology. ; Epigenetics. ; Respiratory Physiology.
    Description / Table of Contents: Chapter 1. Introduction to Lung Diseases -- Chapter 2. Introduction to Epigenetics -- Chapter 3._Epigenetic mechanisms in Inflammation -- Chapter 4. Epigenetic regulator of inflammatory gene expression -- Chapter 5. Epigenetics of Asthma -- Chapter 6_. Epigenetic optimization in chronic obstructive pulmonary disease (COPD -- Chapter 7. Epigenetics of Lung Cancer -- Chapter 8. Epigenetics of Pulmonary Tuberculosis -- Chapter 9. Epigenetics of Idiopathic Pulmonary Fibrosis -- Chapter 10. Epigenetics of influenza-A virus infection -- Chapter 11. Epigenetics of rhinovirus -- Chapter 12. Epigenetics of SARS-Cov2 (Covid-19) -- Chapter 13. Epigenetics of Haemophilus Influenzae -- Chapter 14. Future Prospects and Challenges -- Chapter 15. Targeting epigenetics in pulmonary arterial hypertension.
    Abstract: This book discusses the role of epigenetics in pathogenesis of different pulmonary diseases, including chronic obstructive pulmonary disease, lung cancer, pulmonary tuberculosis, idiopathic pulmonary fibrosis and pulmonary infections. It also explores post-translational modifications in DNA and histones for improving the understanding of lung diseases. This book helps in understanding the epigenetic mechanisms towards the development of novel diagnostic and therapeutic approaches. Further, the book provides insight into the underlying molecular mechanisms involved in the epigenetic regulation of inflammation, which may have novel implications in designing small molecule inhibitors that target the epigenetic machinery for the effective treatment of a variety of inflammation‑related diseases. This book is a valuable resource for academics, research and industry professionals working in respiratory biology.
    Type of Medium: Online Resource
    Pages: XV, 266 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819947805
    URL: https://doi.org/10.1007/978-981-99-4780-5
    DOI: 10.1007/978-981-99-4780-5
    DDC: 615
    Language: English
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  • 3
    Electronic Resource
    Electronic Resource
    Drosophila OVO zinc-finger protein regulates ovo and ovarian tumor target promoters (1998)
    Springer
    Development genes and evolution 208 (1998), S. 213-222 
    Details
    ISSN: 1432-041X
    Keywords: Key words C2H2 zinc-finger ; Oogenesis ; Germline sex determination ; Transcription factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  The ovo + and ovarian tumor + genes function in the germline sex determination pathway in Drosophila, but the hierarchical relationship between them is unknown. We found that increased ovo + copy number resulted in increased ovarian tumor expression in the female germline and increased ovo expression in the male germline. The ovo locus encodes C2H2 zinc-finger proteins. Bacterially expressed OVO zinc-finger domain bound to multiple sites at or near the ovo and ovarian tumor promoters strongly suggesting that OVO is directly autoregulatory and that ovarian tumor is a direct downstream target of ovo in the germline sex determination hierarchy. Both positive and negative regulation by OVO proteins appears likely, depending on promoter context and on the sex of the fly. Our observation that two strong OVO-binding sites are at the initiator of the TATA-less ovo-B and ovarian tumor promoters raises the possibility that OVO proteins influence the nucleation of transcriptional pre-initiation complexes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004270050175
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  • 4
    Electronic Resource
    Electronic Resource
    New AUG initiation codons in a long 5’ UTR create four dominant negative alleles of the Drosophila C2H2 zinc-finger gene ovo (1998)
    Springer
    Development genes and evolution 207 (1998), S. 482-487 
    Details
    ISSN: 1432-041X
    Keywords: Key words C2H2 zinc-finger ; Germ-line sex determination ; Dominant-negative ; Oogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Promoters active in the germline produce OVO-A and OVO-B mRNAs encoding isoforms of a putative transcription factor. The isoforms have a common C2H2 zinc-finger domain but different N-termini that include potential effector domains. Single point mutations in three dominant-negative ovo D mutations result in new in-frame initiation codons in OVO-B mRNAs and amino acid substitutions within charged regions of OVO-A proteins. Three lines of evidence suggest that the dominant activity is due to the new initiation codons in OVO-B mRNAs and not the amino acid substitutions in OVO-A. First, we made a fourth ovo D allele by inserting a new in-frame AUG. This ovo D4 allele encodes a nearly full-length OVO-A isoform from OVO-B mRNAs. Second, engineered stop codons in ovo D1 downstream of the new AUG abolished dominant negative activity. Third, a substantial deletion of an OVO-A region encoding a highly charged amino acid domain fully rescued loss-of-function ovo alleles. These data suggest that ovo D mutations result in inappropriate expression of OVO-A in the female germline.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004270050139
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  • 5
    Electronic Resource
    Electronic Resource
    Demasculinization of X chromosomes in the Drosophila genus (2007)
    [s.l.] : Nature Publishing Group
    Nature 450 (2007), S. 238-241 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] X chromosomes evolve differently from autosomes, but general governing principles have not emerged. For example, genes with male-biased expression are under-represented on the X chromosome of D. melanogaster, but are randomly distributed in the genome of Anopheles gambiae. In ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature06330
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  • 6
    Electronic Resource
    Electronic Resource
    Constraint and turnover in sex-biased gene expression in the genus Drosophila (2007)
    [s.l.] : Nature Publishing Group
    Nature 450 (2007), S. 233-237 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Both genome content and deployment contribute to phenotypic differences between species. Sex is the most important difference between individuals in a species and has long been posited to be rapidly evolving. Indeed, in the Drosophila genus, traits such as sperm length, genitalia, and gonad ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature06323
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  • 7
    Electronic Resource
    Electronic Resource
    Tiling DNA microarrays for fly genome cartography (2006)
    [s.l.] : Nature Publishing Group
    Nature genetics 38 (2006), S. 1101-1102 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] In a few remarkable years, we have witnessed the sequencing of a plethora of genomes, including our own. Surely it will take some time to develop a true understanding of these data as this information continues to transform biology. Perhaps sequencing is entering a phase of consolidation, where the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1006-1101
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  • 8
    Electronic Resource
    Electronic Resource
    Sex, flies and microarrays (2001)
    [s.l.] : Nature Publishing Group
    Nature genetics 29 (2001), S. 355-356 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Gene expression microarrays generate stunningly large data sets that require many hours of staring at overwhelmingly long spreadsheets and the frequent purchase of more RAM for laboratory computers. When designing a gene expression experiment, however, perhaps one should imagine that only a single ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1201-355
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  • 9
    Electronic Resource
    Electronic Resource
    Calcified Microspheres as Biological Entities and Their Isolation from Bone (1999)
    Springer
    Journal of molecular histology 31 (1999), S. 455-470 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Calcified microspheres, about 1 µm in diameter, appear at sites of bone formation where they invest the collagenous matrix, become confluent and disappear. Evidence that the particle boundaries are not lost with compaction but merely deformed is supported in section by the granular histochemical staining of the inorganic phase for bone salt, lipid, fibronectin and acid phosphatase in osteomalacic, acid-etched and normal human bone. Their persistence as discrete objects is confirmed by the application of methods for their isolation from the collagenous matrix of immature mouse calvarium and mature bovine femur. Five methods have been used to extract them and include (i) biochemical, (ii) chemical, (iii) mechanical, (iv) pyrogenous and (v) biological separation. Under the optical microscope, all isolates consisted of similar discrete objects and bridged assemblies, whose birefringence varied with treatment. After decalcification, their organic ‘ghosts’ remained. Each isolated microsphere had a complex substructure of clusters of non-collagenous calcified filaments surrounding a less dense centre. The filaments were 5 nm in diameter with a 5 nm periodicity and regular fine interfilamentous connections. It is concluded that the microspheres are independent, complex, pervasive and central to the containment (i.e. packaging) of calcium phosphate in bone. Their extraction will enable further analysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1003707909842
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  • 10
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    Mono- and Cocultures of Bronchial and Alveolar Epithelial Cells Respond Differently to Proinflammatory Stimuli and Their Modulation by Salbutamol and Budesonide (2015)
    American Chemical Society
    Details
    Publication Date: 2015-07-06
    Print ISSN: 1543-8384
    Electronic ISSN: 1543-8392
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society
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