ISSN:
1573-4919
Keywords:
zinc-finger protein
;
nuclear localization signal
;
base excision repair
;
microinjection
;
dominant-negative mutant
;
NAD metabolism
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract Poly(ADP-ribose) polymerase (PARP) participates in the intricate network of systems developed by the eukaryotic cell to cope with the numerous environmental and endogenous genetoxic agents. Cloning of the PARP gene has allowed the development of genetic and molecular approaches to elucidate the structure and the function of this abundant and highly conserved enzyme. This article summarizes our present knowledge in this field.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00928438
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