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Structure and function of poly(ADP-ribose) polymerase

  • Part II: Poly(ADP-ribosyl)ation
  • A. Structure and Enzymology of Poly(ADP-ribose) Polymerase
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Abstract

Poly(ADP-ribose) polymerase (PARP) participates in the intricate network of systems developed by the eukaryotic cell to cope with the numerous environmental and endogenous genetoxic agents. Cloning of the PARP gene has allowed the development of genetic and molecular approaches to elucidate the structure and the function of this abundant and highly conserved enzyme. This article summarizes our present knowledge in this field.

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Authors and Affiliations

  1. Ecote Supérieure de Biotechnologie de Strasbourg, Unité de Cancérogénèse et de Mutagénèse Moléculaire et Structurale du Centre National de la Recherche Scientifique, Boulevard Sébastien Brant, 67400, Illkirch-Graffenstaden, France

    Gilbert de Murcia, Valérie Schreiber, Miguel Molinete, Murielle Masson, Claude Niedergang & Josiane Ménissier de Murcia

  2. Unité des Mécanismes de Division Cellulaire et du Développement, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, 67084, Strasbourg Cedex, France

    Olivier Poch

  3. Laboratoire de Biologie et Génétique du Développement, Centre National de la Recherche Scientifique, Université de Rennes, 35042, Rennes Cedex, France

    Bénédicte Saulier

Authors
  1. Gilbert de Murcia
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  2. Valérie Schreiber
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  3. Miguel Molinete
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  4. Bénédicte Saulier
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  5. Olivier Poch
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  6. Murielle Masson
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  7. Claude Niedergang
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  8. Josiane Ménissier de Murcia
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de Murcia, G., Schreiber, V., Molinete, M. et al. Structure and function of poly(ADP-ribose) polymerase. Mol Cell Biochem 138, 15–24 (1994). https://doi.org/10.1007/BF00928438

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