Publication Date:
2007-11-16
Description:
Background: Diffuse large B-cell lymphomas (DLBCL) are the most common type of lymphomas and have heterogeneous clinical behavior. Three commonly dysregulated genes (BCL-2, BCL-6 and C-MYC) have been recognized in DLBCL based on molecular gene profile studies. The 8q24 C-MYC rearrangement is found in 10–15% of patients with DLBCL. C-MYC status in HIV+ and HIV− population with DLBCL is not well studied and the role of C-MYC in the survival status of these two group is worthy of exploration. Design: Ninety-one patients with DLBCL diagnosed between 01/2005– 04/2007 were included in this study. Atypical Burkitt lymphoma according to WHO classification was excluded. Patients were divided into HIV+ (26 cases, average 44.5 ± 10.7 y/o) and HIV− (65 cases, average 65 ± 17.2 y/o) groups. Eight plasmablastic lymphomas (PBL) (7 HIV+ and 1 HIV−) were diagnosed. FISH (Vysis, Des Plaines, IL) break-apart for the 8q24 C-MYC rearrangement (91 cases), immunohistochemical stains for CD20, CD3, BCl-2, CD10, BCl-6, EBER in all cases, p53 (available for 78 cases), and proliferation rate by Ki-67 (available for 89 cases) were performed. Categorical variables were compared with the Fisher exact test. Numerical variables were compared by either the t test or the Wilcoxon rank sum test, as appropriate. The Kaplan-Meier method was used to estimate survival. The Log-Rank test was used to compare survival in the following groups: HIV+ vs. HIV−, C-MYC+ vs. C-MYC−, Ki-67 proliferation ≥ 90% vs.
Print ISSN:
0006-4971
Electronic ISSN:
1528-0020
Topics:
Biology
,
Medicine
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