ISSN:
1434-4475
Keywords:
Conformational analysis
;
NMR spectroscopy
;
1,3-Dioxanes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary The conformation of a series of 5-nitro-1,3-dioxanes, 1,3-dioxane-5-hydroxylamines and the corresponding nitrones, obtained from the latter, has been studied by NMR spectroscopy. In the case of the nitrones, a preferred conformation of the -N(O)CHR 3 substituent to the C5, N single bond was found, and it was concluded therefrom on the identical conformational behaviour of the nitro analogoues. A structurally similar spiro compound confirms the suggestions given. In the case of the spiro compound, the intramolecular N-inversion process could be studied by dynamic NMR spectroscopy; the free energy of activation is given.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00809965
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