ISSN:
1432-1211
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract In this report we describe a new diallelic gene system, Arp aand Arp b, which codes for surface antigens on murine lymphocytes. Arp bis present only in a mutant strain of BALB/c which is designated BALB/c-Arp b. Normal BALB/c and all other strains of mice tested express Arp a. The Arp bmutation is associated with a newly discovered polymorphism of the Peptidase-7 enzyme, Pep-7b, which codes for a variant form of the enzyme with a faster anodal mobility on electrophoresis than the commonly known form. The Arp locus controls a range of alloimmune interactions between Arp incompatible lymphocytes. These include mixed lymphocyte reactivity, host-versus-graft and graft-versus-host reactions and the development of weak cytotoxic but strong cytostatic effector lymphocytes which are allo- as well as autoreactive. The association between Arp and Pep-7 and the biological significance of the Arp locus are discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00345971
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